Jose Gome

Design animal experiments to measure the physiological changes induced by small molecules. Specifically we determine the changes induced by small molecules to renal and cardiovascular system in mice.

Carryout toxicology studies using mice to establish the toxicity of a drug to the cardiovascular system.

Develop a human kidney organoid system to conduct toxicology studies. Human kidney organoids are new in vitro three dimensional alternatives to classical, whole-animal test systems.

Currently I serve as Principal Investigator (PI) responsible for all phases of murine animal research projects including the planning and execution of experiments, preparation and evaluation of data, coordinating collaborative research efforts, and presentation of results at seminars and meetings.

As PI I collect and analyze experimental data and report the findings as scientific manuscripts in high quality peer-reviewed journals-some of my papers are presented in the Publications section.

Design and perform animal physiological experiments to determine changes in the cardio, renal brain circulatory system after different diets.

Responsible for training and supervising students, interns and postdoctoral fellows during the development of their scientific projects.

Develop a collaborative project to determine a new market for human aortic aneurysm, a disease with no molecular marker.

• Discover a new function for renal progenitor cells in blood pressure control using mice models.
• Maintained high levels of confidentiality to protect data quality and project research.
• Followed best practices and scientific protocol to reach defensible conclusions based on solid evidence.
• Performed scientific research on multiple projects. These collaborations resulted in the publication of 7 papers in peer review journals.
• Identified genes that control the differentiation of renal mesenchymal stromal cells and developed strategies to program their differentiation to juxtaglomerular-like cells. Validating new targets for treatment of hypertension.
• Discover a new molecular pathway involved in cardiac repair after myocardial infarction using three mice lines I developed

Designed and developed biologically active peptides that control cellular apoptosis using protein-protein interactions domains.

Discovered a new function in cell death for the interferon gamma receptor.

Published 9 papers with 4 as first authors and one book chapter as first author.

Presented oral and poster presentations in several scientific meetings.

Graduated with a PhD in Pharmacology from the Department of Pharmacology.