Junjie Cao
Principle Scientist
Mansfield,MA
Summary
A self-motivated, extremely curious, quick at learning, clear thinking, data-driven decision maker, observant and attentive to unexpected details, hardworking scientist with more than six (6) years of analytical method development/method validation/method transfer/MassHunter automated workflow development experience in pharmaceuticals and medical device chemical characterization analysis for regulatory submission; pharmaceuticals deformulation; impurity/purity/excipient QC analysis; polymer deformulation; material failure investigation; A great variety of academic research experience including, photo catalysis, chiral catalysis, polymer synthesis, organic synthesis and characterization experience in the development of nucleotide based nanoparticle synthesis for drug delivery.
Overview
14
14
years of professional experience
6
6
years of post-secondary education
Work History
Lead Writer
Jordilabs LLC
Mansfield, United States
08.2020 - Current
- Designed and developed automated data analysis workflows for complex GC/HPLC-MS data for pharmaceuticals and Medical Device chemical characterization
- Gathered MS, compound structure, and physicochemical data using literature search skills, built project specific compound database and large chemical database (~55,000) compounds) with toxicological data to facilitate data interpretation and downstream toxicological assessment
- Reviewed technical data, designed and accurately communicated new strategies when unexpected analytical complexity occurs.
- Made and coordinated technical writing assignments to team members for optimal quality and efficiency
Senior Chemist
JordiLabs LLC
Mansfield, United States
06.2019 - 08.2021
- Developed, performed and validated analytical methods for pharmaceuticals impurities and medical device extractable and leachable qualitative and quantitative analysis using a combination of GC-MS (QToF and QqQ), LC-MS (QToF and QqQ) , UHPLC/HPLC-UV-CAD and SEC-Light Scattering
- Authored and reviewed SOPs technical reports for regulatory submission and impurity investigation reports
- Ordered, calibrated, troubleshot and maintained laboratory equipments in good working order.
SEC/GPC Group Leader
JordiLabs LLC
Mansfield, United States
11.2018 - 06.2019
- Led the SEC/GPC analytical development group to support analysis in areas of biologics characterization, polymer deformulation, polymer based material failure investigation, excipient identification/quantitation using a combination of standardized SEC and triple-detection SEC technology
- Maintained and troubleshot to ensure laboratory equipments are in working order
- Achieved record breaking on-time delivery rate and growth rate.
Senior Chemist-SEC/GPC
JordiLabs LLC
Mansfield, United States
08.2016 - 10.2018
- Worked with a team of scientists to design, develop and implement analytical strategies for polymer characterization, material deformulation, material failure investigation and good-bad comparison investigations using size exclusion chromatography (SEC) with RI and Light scattering detection.
- Interpreted SEC results, authored SEC analysis reports, and discuss results with co-workers and clients.
Research Assistant, Prof. Ke Zhang
Northeastern University
Boston, United States
09.2013 - 03.2016
- Gathered research project related data and literature findings to guide the progress of the project.
- Designed and synthesize DNA-self-immolative polymer amphiphilic nanoparticles for controlled cocktail drug delivery
- Characterized the chemical and physical properties of the synthesized nanoparticles using a combination of technics including SEC, HPLC-UV, MALD-MS, NMR, FTIR and gel electrophoresis.
Research Assistant
Tsinghua University
Beijing
08.2011 - 09.2012
- Designed and Gathered FTIR data to support the proposed reaction mechanism for the project: "Mechanistic Study of Photocatalytic Degradation of Perfluorooctanic Acid by In2O3"
Research Assistant
East China Normal University
Shanghai
06.2009 - 06.2011
- Designed and synthsized bioactive compounds: Cyanosilylation of α-trifluromethyl-γ-carbonyl Esters using tandem reaction strategies; developed “Waste as Catalyst/Cocatalyst” Strategy
- Gathered the researching finding data and presented the results
Undergraduate Research Assistant
Northeastern University
Shanghai
04.2008 - 07.2009
- Performed organic synthesis laboratory techniques including inert atmosphere reaction technique, chromatographic purification techniques
- Researched literature, designed and Synthesized a group of Non-peptide small molecules to inhibit p53/MDM2 interaction for cancer therapy
Education
Master of Science - Chemistry
Northeastern University
Boston 09.2013 - 05.2016
Bachelor of Science - Chemistry
East China Normal University
Shanghai, China 09.2006 - 07.2010
No Degree - Drug And Medical Device Development
MIT XPro
Boston 05.2001 -
Skills
Expert level knowledge and experience using the following technologies to solve complex analytical problems: FTIR, GC-FID, GC-MS, Headspace GC-MS (MS 7890), GC-QToF (Agilent 7200, 7250), GC-QqQ (7010B), HPLC, UHPLC, LC-QqQ (Agilent 6470), LC-QToF (Agilent 6545, 6545XT), PYMS; Wyatt SEC-MALS, OMNISEC SEC/GPC; Viscotek GPC
Publications
- Cao, Jun‐Jie, Feng Zhou, and Jian Zhou. "Improving the Atom Efficiency of the Wittig Reaction by a “Waste as Catalyst/Co‐catalyst” Strategy." Angewandte Chemie International Edition 49, 29 (2010): 4976-4980.
- Liu, Yun-Lin, Bo-Lun Wang, Jun-Jie Cao, Long Chen, Yong-Xue Zhang, Chao Wang, and Jian Zhou. "Organocatalytic asymmetric synthesis of substituted 3-hydroxy-2-oxindoles via Morita− Baylis− Hillman reaction." Journal of the American Chemical Society 132, 43 (2010): 15176-15178
- Liu, Yun-Lin, Feng Zhou, Jun-Jie Cao, Cong-Bin Ji, Miao Ding, and Jian Zhou. "A facile method for the synthesis of oxindole based quaternary α-aminonitriles via the Strecker reaction." Organic & biomolecular chemistry 8, 17 (2010): 3847-3850
- Li, Xiaoyun, Pengyi Zhang, Ling Jin, Tian Shao, Zhenmin Li, and Jun-Jie Cao. "Efficient photocatalytic decomposition of perfluorooctanoic acid by indium oxide and its mechanism." Environmental science & technology 46, 10 (2012): 5528-5534.
- Jun-Jie Cao, Jian Zhou. “Novel efficient synthesis of bioactive alpha-trifluoromethyl-gamma-carbonyl esters”, 2014-02-12, 201110034561.x/ ZL201110034561.x
Timeline
Lead Writer
Jordilabs LLC
08.2020 - Current
Senior Chemist
JordiLabs LLC
06.2019 - 08.2021
SEC/GPC Group Leader
JordiLabs LLC
11.2018 - 06.2019
Senior Chemist-SEC/GPC
JordiLabs LLC
08.2016 - 10.2018
Research Assistant, Prof. Ke Zhang
Northeastern University
09.2013 - 03.2016
Master of Science - Chemistry
Northeastern University
09.2013 - 05.2016
Research Assistant
Tsinghua University
08.2011 - 09.2012
Research Assistant
East China Normal University
06.2009 - 06.2011
Undergraduate Research Assistant
Northeastern University
04.2008 - 07.2009
Bachelor of Science - Chemistry
East China Normal University
09.2006 - 07.2010
No Degree - Drug And Medical Device Development
MIT XPro
05.2001 -