NIRAJAN BHATTARAI
Pocatello,ID
Overview
8
8
years of professional experience
Work History
Graduate Assistant
Idaho State University
Pocatello, ID
08.2018 - Current
- Proposed and implemented research focused on Drug Discovery in neurological diseases involving nicotinic acetylcholine receptor resulting in two published, three working and one submitted publication.
- Tutored and mentored each batch for PharmD courses, at least five graduate lab rotations, and supervised three undergraduate lab internships over a five-year period.
- Contributed to the creation of four distinct course syllabi and lesson plans, while also managing grading and overseeing the course management system (MOODLE) for the following courses: Human Physiology I and II, Physiological Basis of Drug Design, and Biological Basis of Drug Design
- Conducted operation, maintenance and troubleshooting on different lab instruments like two electrode voltage clamp, OPENTRON robotics, HPLC/Mass SPEC, Surface Plasmon Resonance, AAPTEC peptide synthesizer, gel electrophoresis, Polymerase Chain Reaction, Vis-Spectroscopy.
Part-time CS Student
Idaho State University
Pocatello, ID
05.2020 - Current
- Contributed in development of Augmented Reality(AR)/Virtual Reality(VR) templates for CAES-ISU funded diaster response training for civil and military sector.
- Completed proof of concept study on virtual reality induced motion sickness where teleportation navigation significantly reduced motion sickness experience as compared to walking/running(77% higher) and flying navigation(70% higher)
- Developed a C++-based SIR simulation model of COVID progression, identifying that increases in the Reproduction Number (Ro) and Rate of Transmission (beta), coupled with shorter doubling times, signify heightened feasibility of disease spread.
- Developed algorithm for novel visualization from atac sequence data derived from experimental osterosarcoma mouse model.
- Designed robust database infrastructure for a Central
Idaho based small specialty shop–– “Wind River of the lost Range" on MySQL databases using phpMyAdmin. - Developed machine learning models achieving 96% accuracy for breast cancer classification using Random Forest, 88% accuracy for Alzheimer's image classification employing neural network models like EfficientNet, and 90% accuracy for sentiment analysis of Amazon customer reviews through NLP-based LSTM.
Lecturer
Kantipur College of Medical Sciences
Kathmandu, Bagmati
07.2016 - 08.2017
- Taught pharmaco-epidemiology and bio-pharmaceutics for class of 40 students in diploma level pharmacy program
- Overseen field visits for pharmaco-epidemiology, labs for biopharmaceutics, terminal exams, and counselling for students and parents
Education
PhD in Pharmaceutical Science -
Idaho State University
12-2024
Bachelor of Science -
Institute of Medicine, Tribhuvan University
04.2017
Skills
Programming and Software skills: JAVA, C, python, SQL(phpMyAdmin and PostgreSQL),pytorch, tensorflow, C#, D3js, git version control, git hub, visual studio code, Augmented Reality/Virtual Reality(Unity), R, UML Lucid Chart, HPC(Ragnarok cluster and Falcon supercomputer), google collab, jupyter notebook, latex/Overleaf, Maestro(Schrödinger), graph pad prism, Statistical Package for Social Science, DNASTAR(Lasergene)
Lab Skills: Deconstructive chemical synthesis, Electrophysiology, Surface Plasmon Resonance(Reichardt SR7500), UV-Vis Spectrometer(Thermo Fisher),Flourometry(Varioskan LUX),High Performance Liquid Chromatography(Shimadzu), Gas Chromatography Mass Spectrometry(Agilent 6890), peptide synthesizer(AAPPTEC Focus XI), DNA/RNA preparation, cloning and transformation, Polymerase Chain Reaction, agarose gel electrophoresis, western blot, enzyme-linked immunosorbent assay
Teaching skills: MS office, Moodle management, course
module development, teaching courses(Human Physiology, Biological basis of drug design, pharmacological basis of drug design etc)
Published Publications
- Argade MD, DeCristofano L, Bhattarai N, Schulte MK, Dukat M., Evaluation of galantamine and deconstructed analogs as α7 nAChR and AChE ligands, Results in Chemistry, 01/01/2022, 4, 100286
- Sharma K, Pradhan S, Duffy LK, Yeasmin S, Bhattarai N, Schulte MK., Role of receptors in relation to plaques and tangles in Alzheimer's disease pathology, International Journal of Molecular Sciences, 11/30/2021, 22, 23, 12987
- Basnet RA, Pradhan NE, Bharati LA, Bhattarai NI, Bb B, Sharma BI., To determine the risk factors associated with ectopic pregnancy, Asian J Pharm Clin Res, 2015, 8, 2, 93-7
- Bhattarai N, Basyal D, Bhattarai N., Self medication practice among undergraduate pharmacy students in Kathmandu Valley, Nepal, Int J Pharm Sci Res, 2014, 5, 11, 737-46
Working/submitted publications
- Development of robust, validated and explainable machine learning model for identifying potential acetylcholinesterase inhibitors
- Machine Learning Empowered Drug Discovery in Resource-Constrained Environments: A Proof of Concept on Acetylcholinesterase Inhibitors and Application to Positive Allosteric Modulators of Alpha4beta2 Nicotinic Acetylcholine Receptor
- Development of consensus molecular docking and pharmacophore model for in-silico screening of selective positive allosteric modulators for alpha4beta2 nicotinic acetylcholine receptor
- Herbs and Spices:Modulation of gut microbia for healthy aging
Timeline
Part-time CS Student
Idaho State University
05.2020 - Current
Graduate Assistant
Idaho State University
08.2018 - Current
Lecturer
Kantipur College of Medical Sciences
07.2016 - 08.2017
PhD in Pharmaceutical Science -
Idaho State University
Bachelor of Science -
Institute of Medicine, Tribhuvan University
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