Aditya Krishna
Senior Associate Scientist
Boston,MA
Summary
Driven, hardworking, and ethical scientist with superior organizational and analytical skills combined with unparalleled dedication to research excellence. Well versed in analytical method development, GLP practices, and analytical regulatory requirements, with technical knowledge to conceptualize, design, and implement technical projects and experiments. Dedicated professional with history of utilizing consistent and organized practices in a dynamic and collaborative environment. Skilled in working under pressure and adapting to new situations and challenges to best progress organizational goals.
Overview
8
8
years of professional experience
5
5
years of post-secondary education
1
1
Language
Work History
Senior Associate Scientist
Elektrofi
02.2023 - Current
- Develop and qualify robust analytical methods for quantifying and characterizing proteinaceous and extrinsic particulates in drug products.
- Serve as subject matter expert to support technical transfer to CROs & CDMOs, and contribute to investigations of out-of-specification or out-of-trend results.
- Serve as Analytical Development CMC representative for company partner programs.
- Write and review SOPs, method and instrument qualification protocols, technical reports, certificates of testing, and CMC sections of regulatory filings.
- Perform sample analysis, data interpretation, and continuous technology evaluation to support definition of analytics perform and support cross-functional areas.
- Contribute to patent applications detailing novel discoveries made during research projects.
Associate Scientist
Elektrofi
07.2021 - 02.2023
- Supported formulations and process development group using analytical methods including but not limited to SEC, IEX, and Protein A chromatography, light scattering techniques, flow imaging, microscopy and report data following GLP practices.
- Simultaneously managed several complex projects and working collaboratively to meet company goals and pertinent milestones.
- Authored and modernized SOPs and ELN structures and develop presentations for company partners.
- Developed and implemented AI based neural networks for classification and unsupervised clustering of particulates to derive contaminants, protein degradation attributes, and better inform formulation screening.
- Optimized dissolution of novel microparticle powder and suspension drug products for downstream analytical testing.
- Evaluated surface charge of particles and interfacial stressors to predict stability of suspensions.
- Modeled settling behavior of microparticles and suspensions to evaluate stability in pre-filled syringes.
- Manufactured drug product at bench-scale to support analytical workstreams.
- Manage and train new hires in a fast-paced growing environment to maintain analytical IND readiness.
Analytical Tech-Ops Co-op
Voyager Therapeutics
01.2020 - 05.2020
- Planned and implemented a forced degradation study on drug product for Huntington’s disease.
- Prepared and collected samples for evaluation of effects of oxidation, UV, pH, and temperature on drug product.
- Analyzed and compiled results to characterize Adeno-associated viruses (AAV's) under forced degradation conditions.
- Conducted research to optimize current techniques and validate method transfer from similar drug products.
- Navigated a challenging COVID-19 environment to progress experiments and meet storage and stability timelines.
- Trained in qPCR, ddPCR, MFI, fluorescence, static and dynamic light scattering, SEC-MALS, denaturing gel.
Analytical Development Co-op
Vertex Pharmaceuticals
01.2019 - 07.2019
- Structure, Elucidation, Trace Analysis, and Biologics group in AD.
- Assisted in the development of analytical methods including, but not limited, to RP-HPLC, IEX-HPLC, GLC, LC-MS.
- Independently conducted IEX-HPLC and RP-HPLC analyses on more than a thousand cell samples.
- Performed data analysis on generated chromatograms using Empower software and summarized results from experiments.
- Calibrated and troubleshoot laboratory instruments such as Weight Balances, HPLC, MS.
- Experienced in dealing with toxic chemicals such as cyanide and formaldehyde.
- Attended, prepared, and presented in several meetings amongst different departments to share methods and results from testing.
Research Intern
Chinese University of Hong Kong
07.2017 - 08.2017
- Assisted phD students with research for stem cell tissue engineering.
- Conducted experiments in biomedical hydrogel design and cell-biomaterial interactions.
- Prepared tables, graphs and fact sheets to summarize research results.
- Participated in conferences amongst south east Asian universities and presented research progress.
Intern
Adventist Hospital
12.2015 - 12.2015
- Read and analyzed memos, submissions and reports to determine their significance
- Compiled data, and prepared papers for consideration and presentation
- Coordinated and directed office services, such as records and several other documents
Education
Bachelor of Science - Biology
Northeastern University
Boston, Massachusetts 09.2016 - 06.2021
Skills
Software: Microsoft Office, Adobe Creative Suite, Maya, statistics in R & Python, Empower, Excalibur, ChemStation, JMP, Graphpad Prism, ELNs, Zen product suite (Zeiss), ImageJ
Timeline
Senior Associate Scientist
Elektrofi
02.2023 - Current
Associate Scientist
Elektrofi
07.2021 - 02.2023
Analytical Tech-Ops Co-op
Voyager Therapeutics
01.2020 - 05.2020
Analytical Development Co-op
Vertex Pharmaceuticals
01.2019 - 07.2019
Research Intern
Chinese University of Hong Kong
07.2017 - 08.2017
Bachelor of Science - Biology
Northeastern University
09.2016 - 06.2021
Intern
Adventist Hospital
12.2015 - 12.2015