Alexandra Fuller
Gainesville,Florida
Summary
Neurodegenerative therapies specialist with key role in support of activities for preclinical gene therapy research and development. Experience centralized in NHP and rodent biodistribution/general toxicology CNS studies, program and study coordination, development of histology-based assays and plasmid cloning.
Overview
14
14
years of professional experience
Work History
SENIOR ASSOCIATE SCIENTIST
NysnoBio
01.2023 - Current
- Design study protocols for biodistribution and general toxicology studies.
- Close collaboration with CRO contacts to create contracts, protocols, and manage shipment of biological material.
- Quantification of target area coverage and distribution of intraparenchymal test article.
- Analysis of protein markers for quantification using image analysis software.
- Plate based protein assays using non-human primate and rodent tissues.
- Handling, evaluation and harvest of small and large animals for in vivo studies.
- Basic pathology review and documentation of CNS and peripheral tissues for cellular inflammatory markers post-AAV vector injection.
- Development of timelines and budget for project completion.
SCIENTIST II
Lacerta Therapeutics
01.2022 - 01.2023
- Coordinate histological experiments in non-human primates and rodents.
- Design experimental designs for in vivo studies in non-human primates and rodent studies.
- CRO relationship management.
- Ensured protocols and SOPs were followed by CRO teams.
- Analysis of protein markers for quantification using image analysis software (HALO, IndicaLabs, ImageJ)
- Responsible for generation of program slide decks for internal and external scientists' information flow
- Handling, evaluation and harvest of rodents for in vivo studies.
- Basic pathology review and documentation of CNS and peripheral tissues for cellular inflammatory markers post-AAV vector injection.
RESEARCH ASSISTANT, RESEARCH ASSISTANT II, SCIENTIST I
Lacerta Therapeutics
01.2019 - 01.2022
- Managed histology team and all samples from multiple programs to ensure efficient and timely processing.
- Designed, optimized and executed histology and immune based assays.
- Expert tissue sectioning (frozen and FFPE)
- Microdissection of dorsal root ganglion (DRG) nerves from rodents.
- Plasmid cloning for AAV packaging.
- Collaborated with multidisciplinary teams to develop innovative research methodologies and strategies.
- Mentored junior researchers, promoting professional growth and skill development within the team.
- Developed innovative research methodologies for improved data collection and analysis.
ADMINISTRATIVE ASSOCIATE
Deloitte LLC.
01.2018 - 01.2019
- Supported Deloitte's Orlando Delivery Center using self-initiated strategy and protocols to develop office administration practices for a team of 9.
- Coordinate administrative support in a team environment, apply advanced technical skills to use business applications, tools and processes to effectively share and complete work in a seamless manner.
- Track, research, and manage time/expenses to proactively enter and submit on behalf of Partners and Managing directors.
- Support work with national and local teams virtually and in person.
- Expert understanding of Deloitte's network of business support services to delegate work requests and partner with national and local teams to deliver work effectively.
OPERATIONS SPECIALIST
Apple Inc.
01.2014 - 01.2018
- Advanced to lead a team to maintain inventory accuracy and organization
- Created, maintained, and provided data analysis regarding inventory tracking, management, and forecasting
- Managed internal investigations into inventory discrepancies for internal and external shrink
- Managed vendor and contractor relationships with courier services to facilitate interstate transit of high dollar value hardware between locations
- Created data set macros within Excel to track changes to large scale data sets over time that were then deployed across Apple Stores in the state of Florida
- Calculated loss over time and budget allocation for store resources.
Education
Botany Research/B.S. -
University of Florida
Gainesville, FloridaPlant Science/A.S -
Valencia College
Orlando, FloridaSkills
- Project Coordination and Management
- GLP
- Histology & Plate-Based Assays
- PCR & Gel Electrophoresis
- Protocol Creation & Optimization
- Microsurgery/Microdissection
- Image Analysis
- CNS Specialization
- Microscopy
- Neurodegenerative animal models
- Lab equipment maintenance
- Strong analytical skills
- Immunohistochemistry expertise
- Cell culture
- Experimental design
- Pathology review
Websites
Posters And Presentations
- Biodistribution And Activity Of A Novel AAV-hFXN Expression Vector In The MCK Mouse Model Of Friedreich's Ataxia, International Congress for Ataxia Research, March, 2022, Dallas, Texas
- Biodistribution And Activity Of A Novel AAV-hFXN Expression Vector In The Rodent CNS, International Congress for Ataxia Research, March, 2022, Dallas, Texas
Unique Skills
- Asset Management
- Event Planning
- Budget Creation
- Facilities Management
- MacOS / Windows
- MS Office 365
- Office Coordination
- Professional Writing
- Technical Writing
- Vendor Relations
Timeline
SENIOR ASSOCIATE SCIENTIST
NysnoBio
01.2023 - Current
SCIENTIST II
Lacerta Therapeutics
01.2022 - 01.2023
RESEARCH ASSISTANT, RESEARCH ASSISTANT II, SCIENTIST I
Lacerta Therapeutics
01.2019 - 01.2022
ADMINISTRATIVE ASSOCIATE
Deloitte LLC.
01.2018 - 01.2019
OPERATIONS SPECIALIST
Apple Inc.
01.2014 - 01.2018
Botany Research/B.S. -
University of Florida
Plant Science/A.S -
Valencia College