Arghya Ghosh
Postdoctoral Research Scientist
Medford,MA
Summary
Postdoctoral Fellow with at Tufts University. Organized with research and presentations, peers and superiors on research analysis. Published research findings through peer-reviewed articles and analyzed results tailoring to possible future applications.
Overview
8
8
years of professional experience
9
9
years of post-secondary education
Work History
Postdoctoral Research Associate
Tufts University
01.2021 - Current
- Performed molecular dynamics simulations, quantum simulations and enhanced sampling methods to understand and design cyclic peptides and N-methylated cyclic peptides to modulate protein-protein interactions.
Graduate Student
01.2017 - 12.2021
- Performed methods of computational chemistry to study transition metal systems with emphasis on understanding photochemical behavior associated with derivatives of vitamin B12.
- Enzymatic catalysis in vitamin B12-dependent enzymes
Unraveling the origin of the Co-C bond activation in the enzymatic reactions catalyzed by AdoCbl-dependent MCM using the combined quantum mechanics/molecular mechanics (QM/MM) approach method. - Photochemical properties of Metalloenzymes
Analyzed the photolytic properties of the Methionine synthase (MetH) enzyme using a QM/MM approach. The effect of the mutation on the photoactivation of Co-C the bond was also explored. The mechanistic insight of light-induced activation of organometallic Co-C bond inside enzymatic environment was explored and provided theoretical evidence of the photo-stability of MetH which is an important enzyme because their malfunctioning causes cardiovascular risks, neural defects, and Alzheimer’s disease. - Photochemical properties of vitamin B12 derivative in solution
The photolytic properties of methylcobalamin in the presence of oxygen were investigated using density functional theory (DFT), time-dependent density functional theory (TD-DFT) and
CASSCF.
Master
University of Louisville
06.2015 - 04.2016
- Optical properties of an impurity-doped quantum dot, under influence of Gaussian white noise
CSIR-NCL
Pune
05.2014 - 07.2014
- Performed Molecular Dynamic study of the effect of pH on structural properties of the protein, polypeptide chain, and relevant free energy surfaces
Education
Postdoctoral Research Associate - undefined
Tufts University
01.2022 - Current
Ph.D. - Chemistry
University of Louisville
Louisville, KY 01.2017 - 12.2021
Master of Science (M.S) - Chemistry
University of Louisville
01.2017 - 02.2020
Skills
Density Functional Theory (DFT), Time-dependent Density Functional Theory (TD-DFT)Multireference Self-Consistent Field Calculations (CASSCF-MCQDPT2), Coupled cluster singles andDoubles (CCSD) method, CASSCF/CASPT2, Semi-empirical MethodsMultiscale modeling like QM/MM, ONIOMMolecular dynamics (in NVT and NPT ensembles), MM calculationsEnhanced Sampling, Bias-Exchange MetadynamicsQuantum Chemistry Packages: Gaussian, Orca, GAMESSMolecular Dynamics/Molecular Docking: GROMACS, PLUMED, AMBER, TagDock, AutoDockLinux Shell ScriptingComputer Languages: FORTRAN, PythonVisualization Softwares: VMD, Pymol, Avogadro, Chimera, GaussView, Chemcraft, GabeditPlotting Softwares: Grace/Xmgr, Gnuplot, Origin, and Excel
Accomplishments
- Experience in using IBM high-performance distributed-memory clusters, Cardinal Research Cluster (CRC) Supercomputer
- Graduate Teaching Assistant
- Department of Chemistry, University of Louisville CHEM-101- Intro to Chemistry CHEM-207 and CHEM-208- Intro to Chemical Analysis (laboratory experiments) CHEM-466 (Advance Physical Chemistry)- Thermodynamics, statistical thermodynamics, chemical equilibrium and reaction kinetics from a molecular point of view CHEM-470- Laboratory experiments and related lecture on properties of gases, thermochemistry, kinetics, electrochemistry, laser techniques in chemical processes, spectroscopic methods including
- UV-VIS, FTIR, and EPR
- Peer Reviewer: International Journal of Molecular Sciences; Molecules.; Polymers; Catalysts; Symmetry;
- Electrochem; Computation; Mathematics, Computational
- Chemistry
- Programs
- Award
- Computational
- Chemistry
- Techniques
- Computer Skills and Programing
- Language
- Award
- Professional
- Activities 5 | Page
- Arghya P
- Ghosh, CV
- Dr
- Piotr Lodowski (University of Silesia, Poland), Dr
- Maria Jaworska (University of Silesia, Poland), Dr
- Justyna Wolinska (Lublin University of Technology)
- Vice- President Chemistry Graduate Student Association (August 2018-June 2020)
- University of Louisville
- Derby Lecture Series (May 2 and 3 2019): Responsible for organizing and implementing all event logistics associated with the 41st annual Derby Lecture Series
- Invited the 2016 Nobel Laureate, Sir J
- Fraser Stoddart to the university for two lectures
- Oversaw fundraising efforts and secured university and corporate funding for the event
- Worked as a graduate representative for Graduate Network of Arts and Science (GNAS) and served as a committee member in the GNAS research fund
- Collaborators
- Leadership/Ma nagement Skill
Affiliations
Member of the American Chemical Society (ACS)
Member of the Kentucky Academy of Sciences (KAS)
Member of Biophysical Society
Member of VIBHA India
Additional Information
- University of Louisville Graduate Network in A&S (GNAS) Research fund award (Spring 2019) University of Louisville Graduate Student Council (GSC) Travel Award (Fall 2019) University of Louisville Graduate Student Council (GSC) Travel Award (Fall 2018) University of Louisville Prestigious Graduate Student Council(GSC) Research Grant Award (2018) University of Louisville International Center Tuition Support Award (Spring 2018) University of Louisville International Center Tuition Support Award (Fall 2018) University of Louisville Graduate Network in A&S (GNAS) Research fund award (Fall 2018) University of Louisville, Department of Chemistry Conference travel award (Fall 2018) University of Louisville Graduate Student Council (GSC) Travel Award (Spring 2018) Winner of best-applied project award in Eastern India Science and Engineering Fair (2014)
Timeline
Postdoctoral Research Associate - undefined
Tufts University
01.2022 - Current
Postdoctoral Research Associate
Tufts University
01.2021 - Current
Graduate Student
01.2017 - 12.2021
Ph.D. - Chemistry
University of Louisville
01.2017 - 12.2021
Master of Science (M.S) - Chemistry
University of Louisville
01.2017 - 02.2020
Master
University of Louisville
06.2015 - 04.2016
CSIR-NCL
05.2014 - 07.2014