Arpit Sharma
Graduate Researcher
Seven Hills,NSW
Summary
Knowledgeable Chemist with solid foundation in research methodologies and data analysis. Successfully contributed to significant academic projects, enhancing understanding of complex subject matters. Demonstrated ability to apply critical thinking and problem-solving skills to research challenges.
Overview
4
4
years of professional experience
9
9
years of post-secondary education
Work History
Research Assistant
Kent State University
07.2023 - 08.2025
- Company Overview: Kent State University, Department of Chemistry and Biochemistry. Website: https://www.kent.edu
- Conducting controlled laboratory experiments.
- Analyzing and developing new techniques and testing the reliability of outcomes.
- Developing practical applications of research findings.
- Designing and refining experimental protocols and instrumentation.
- Calibrating and maintaining laboratory equipment.
- Developing and implementing quality control procedures for chemical synthesis and data collection.
- Managing and track laboratory samples, associated data, and workflows using Laboratory Information Management System (LIMS).
- Preparing detailed laboratory documentation, including research progress reports, SOPs, peer-reviewed journal articles, and experimental protocols aligned with international scientific reporting standards.
- Coordinating with technical staff and mentoring junior researchers, including undergraduate and graduate students.
- Testing compounds and experimental materials for consistency with federal and institutional safety guidelines.
- Utilizing biotechnological approaches and photochemical processes.
- Applying Cancer cells and chemical conversion techniques.
- Organized research materials, maintaining a well-ordered workspace conducive to productivity.
- Participated actively in regular meetings with fellow researchers to discuss project updates, challenges faced, and lessons learned during ongoing activities.
- Collaborated with multidisciplinary teams to develop innovative research methodologies and strategies.
Graduate Researcher
Kent State University
08.2021 - Current
- Company Overview: Kent State University, Department of Chemistry and Biochemistry. Website: https://www.kent.edu
- Designed and synthesized small-molecule platinum-based cancer therapies using medicinal chemistry concepts and multi-step organic and inorganic synthesis.
- Synthesized NIR-photoactivable platinum pharmaceuticals and antibody-conjugated Pt-fluorophore probes with controlled drug release, using click chemistry and photochemical activation techniques to improve bioorthogonal drug targeting.
- Designed and synthesized DNA-Pt-fluorophore complexes for site-specific therapy, demonstrating successful light-triggered activation using gel electrophoresis and cancer cell imaging.
- Collaborative work with Dr. Mao's lab to determine the distribution and intermolecular force between aptamer molecules and specific proteins on the cell surface (Hela) or lipid bilayer by using single-molecule technology. Implemented gel electrophoresis, cell culture, flow cytometry, and magnetic tweezers.
- Kent State University, Department of Chemistry and Biochemistry. Website: https://www.kent.edu
- Analytical & Imaging Techniques: Fluorescence microscopy, confocal imaging, live-cell imaging, spectroscopic techniques (NMR (1H, 13C), UV/Vis, FTIR, fluorescence spectrophotometry, HPLC (RP, SEC, IEX), LC-MS, TEM, SEM, and atomic absorption spectroscopy (AAS)).
- Molecular Biology & Biochemical Techniques: Western blotting, flow cytometry & cell sorting, DNA/RNA isolation, protein purification, gel electrophoresis, PCR, fluorescence- and plate-based techniques, and Surface Plasmon Resonance (SPR).
- Cell Biology & Cancer Research: In vitro cell culture of mammalian cell lines (breast cancer cells: MDA-MB-231; ovarian cancer cells: OVCAR-3, A2780cis), subculturing, and media preparation.
Teaching Assistant
Kent State University
08.2021 - 07.2023
- Company Overview: Kent State University, Department of Chemistry and Biochemistry. Website: https://www.kent.edu
- Helped with grading assignments and tests, providing constructive feedback to students based on results.
- Supported classroom activities, tutoring, and reviewing work.
- Supervising general and analytical chemistry lab sessions, providing accurate experimentation while safeguarding laboratory practices.
- Assisting students with practical chemical analyses, preparing reagents, and setting up experimental equipment.
- Acting as the lead in tutorials and discussions to help students better understand organic, inorganic, and physical chemistry concepts and to clarify lecture content.
- Emphasizing academic integrity and attention to detail when evaluating lab reports, tests, and quizzes.
- Establishing an accepting and productive learning environment by mentoring over 75 students and holding regular office hours.
Education
Ph.D. - Chemistry
Kent State University
Kent, OH 01.2021 - 01.2025
Master of Science - Chemistry
Indian Institute of Technology
Patna, India 01.2018 - 01.2020
Bachelor of Science - Chemistry
G.G.D.S.D College (Panjab University)
Chandigarh, India 01.2015 - 01.2018
Skills
Analytical skills
Troubleshooting
Experimental design
Data analysis
Verbal communication
Good Manufacturing Practices (cGMP)
Good Clinical Practice (GCP)
Good Laboratory Practice (GLP)
Cross-disciplinary partnerships
Scientific writing
Research design
Teamwork and collaboration
Presentations
- Click-Controlled Photo-Uncaging: Click-Assembly of Platinum-Based Photoactive Protecting Groups for Light-Triggered Bioactive Molecule Release, American Chemical Society Cleveland Local Section Meeting in Miniature (MiM), Cleveland, OH, USA, 03/12/25
- Click-Controlled Photo-Uncaging: Click-Assembly of Platinum-Based Photoactive Protecting Groups for Light-Triggered Bioactive Molecule Release, Ohio Inorganic Weekend, 42 W Warren Ave, Detroit, MI, 48202, 11/15/24 - 11/16/24
- PEGylation Effects on Amphiphilic Platinum(IV) Complexes: Influence on Uptake, Activation, and Cytotoxicity, 41st Annual Chemistry Graduate Student Symposium (GSS), 190 Founders Prom, Getzville, NY, 14068, 05/22/24 - 05/24/24
- Exploring the Impact of Head Group Modifications on the Anticancer Activities of Fatty-Acid-like Platinum(IV) Prodrugs: A Structure–Activity Relationship Study, Ohio Inorganic Weekend, Bowling Green, OH, 43403, 11/17/23
- Cytotoxicity and Stability of Liposomal Nanoparticles of Noncovalent Near-Infrared Activable Platinum(IV) Prodrugs, Ohio Inorganic Weekend, Columbus, OH, 43210, 11/04/22
- Engineering Novel Amphiphilic Platinum(IV) Complexes to Co-Deliver Cisplatin and Doxorubicin, 8th Annual Department of Chemistry and Biochemistry Honors Week, Kent, OH, 44242, 04/11/22
- PEGylation Effects on Amphiphilic Platinum(IV) Complexes: Influence on Uptake, Activation, and Cytotoxicity, 36th Annual Graduate Research Symposium, Kent, OH, 44242, 04/07/22
Technical Expertise
Fluorescence microscopy, Confocal imaging, Live-cell imaging, Spectroscopic techniques: NMR (1H, 13C), UV/Vis, FTIR, Fluorescence spectrophotometry, HPLC (RP, SEC, IEX), LC-MS, TEM, SEM, Atomic Absorption Spectroscopy (AAS), Western blotting, Flow cytometry & cell sorting, DNA/RNA isolation, Protein purification, Gel electrophoresis, PCR, Fluorescence- and plate-based techniques, Surface Plasmon Resonance (SPR), In vitro cell culture of mammalian cell lines (breast cancer cells: MDA-MB-231, Ovarian Cancer cells: OVCAR-3, A2780cis), Subculturing, Media preparation, GraphPad Prism, ImageJ, FlowJo, ChemDraw, OriginLab, Mestrenova, Microsoft Office (Word, Excel, PowerPoint, Project)
Achievements Awards
- Debbie Fu-Tai Tuan Graduate Scholarship (2021 & 2022)
- Bush Teaching Award for Graduate students (2023)
- Kent State University Scholarship (2022)
- MacDonald Divisional Award (2025)
- Research Award (2025)
Publications
- Click-Controlled Photo-Uncaging: Click-Assembly of Platinum-Based Photoactive Protecting Groups for Light-Triggered Bioactive Molecule Release, Sharma, A.; Jogadi, W.; Kshetri, M.; Alqarni, S.; Amin, M.A.; Cheline, M.; Akter, S.; Lin, Z.; Park, J.; Solmen, J.; Caraway, J.; Brattley, M.; Zheng, Y.-R., JACS, 2025, https://pubs.acs.org/doi/10.1021/jacs.5c02579
- PEGylation Effects on Amphiphilic Platinum(IV) Complexes: Influence on Uptake, Activation, and Cytotoxicity, Arpit Sharma 1, Md Al Amin 1, Man B. Kshetri 1, Suha Alqarni 1,2, Wjdan Jogadi 1, Jordan Solmen1, Zexin Lin 1, Shirin Akter 1, and Yao-Rong Zheng 1, Pharmaceutics, 2025, 17, 4, 440, https://doi.org/10.3390/pharmaceutics17040440
- Dynamic Structures and Fast Transition Kinetics of Oxidized G-Quadruplexes, Jiahao Ji, Arpit Sharma, Pravin Pokhrel, Deepak Karna, Shankar Pandey, Yao-Rong Zheng, Hanbin Mao, Small Journal, 2024, https://doi.org/10.1002/smll.202400485
- NIR-Activatable, Sequence-Specific Pt(IV)–DNA Scaffolds for Responsive Uncaging, Sharma, Arpit; Kshetri, Man; Karna, Deepak; Amin, Md; Akter, Shirin; Mao, Hanbin; Zheng, Yao-Rong, Angewandte Chemie, 2025, Manuscript Submitted
- Logic-gated Modulation of Cell Migrations via Mesoscale Mechanical Uncaging Effects, Deepak Karna, Shin Watanabe, Grinsun Sharma, Arpit Sharma, Yaorong Zheng, Ibuki Kawamata, Yuki Suzuki, and Hanbin Mao, ACS Nano, 2025
- Engineering Novel Amphiphilic Platinum(IV) Complexes to Co-Deliver Cisplatin and Doxorubicin, Jogadi, W.; Kshetri, M.B.; Alqarni, S.; Sharma, A.; Cheline, M.; Amin, M.A.; Sheets, C.; Nsoure-Engohang, A.; Zheng, Y.-R., Molecules, 2024, 29, 4095
- Exploring the Impact of Head Group Modifications on the Anticancer Activities of Fatty-Acid-like Platinum(IV) Prodrugs: A Structure–Activity Relationship Study, Kshetri, M.; Jogadi, W.; Alqarni, S.; Datta, P.; Cheline, M.; Sharma, A.; Betters, T.; Broyles, D.; Zheng, Y.-R., Int. J. Mol. Sci., 2023, 24, 13301
- Cytotoxicity and Stability of Liposomal Nanoparticles of Noncovalent Near-Infrared Activable Platinum(IV) Prodrugs, Arpit Sharma 1, Md Al Amin 1, Man B. Kshetri 1, Suha Alqarni 1,2, Wjdan Jogadi 1, Jordan Solmen 1, Zexin Lin 1, Shirin Akter 1, and Yao-Rong Zheng 1, Manuscript in preparation
Research
Kent State University, Graduate Researcher, Department of Chemistry and Biochemistry, 08/2021, Present, Designed and synthesized small-molecule platinum-based cancer therapies using medicinal chemistry concepts and multi-step organic and inorganic synthesis., Synthesized NIR-photoactivable platinum pharmaceuticals and antibody-conjugated Pt-fluorophore probes with controlled drug release, using click chemistry and photochemical activation techniques to improve bioorthogonal drug targeting., Designed and synthesized DNA-Pt-fluorophore complexes for site-specific therapy, demonstrating successful light-triggered activation using gel electrophoresis and cancer cell imaging., Collaboration work with Dr. Mao lab to determine the distribution and intermolecular force between aptamers molecules and specific proteins on the cell surface (Hela) or lipid bilayer by using single-molecule technology.
Timeline
Research Assistant
Kent State University
07.2023 - 08.2025
Graduate Researcher
Kent State University
08.2021 - Current
Teaching Assistant
Kent State University
08.2021 - 07.2023
Ph.D. - Chemistry
Kent State University
01.2021 - 01.2025
Master of Science - Chemistry
Indian Institute of Technology
01.2018 - 01.2020
Bachelor of Science - Chemistry
G.G.D.S.D College (Panjab University)
01.2015 - 01.2018
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