Jer-Yuan (Arthur) Hsu

Accomplished scientific leader with extensive experience at NGM Biopharmaceuticals, driving drug discovery and development programs. Proven track record in resource optimization and cross-functional partnerships, delivering multiple IND candidates. Expertise in metabolism, oncology, and immunology research, complemented by strong project management and effective communication skills.

• Ilt3-binding agents and methods of use thereof, Suzanne Christine Crawley, Jer-Yuan Hsu, Daniel David Kaplan, Betty Chan Li, Vicky Yi-Bing Lin, Seth Malmersjö, Kevin James Paavola, Julie Michelle Roda, Yan Wang, US20210221887A1, 12/17/20
• B7-h7-binding agents and methods of use thereof, Jer-Yuan Hsu, Suzanne Christine Crawley, WO2020041300A1, 08/21/18
• Compositions and methods for modulating body weight, Jer-Yuan Hsu, Yu Chen, Suzanne Christine Crawley, Hui Tian, Wenyan Shen, Jie Tang, Jared Martin Higbee, WO2017152105A1, 03/04/16
• Compositions and methods of use for treating metabolic disorders, Darrin Anthony Lindhout, Raj Haldankar, Hui Tian, Jer-Yuan Hsu, US20160031960A1, 07/30/14, 12/05/17

• The Fibronectin-ILT3 Interaction Establishes a Stromal Checkpoint that Suppresses Myeloid Cells, Paavola KJ, Roda JM, Lin VY, Chen P, O’Hollaren K, Ventura R, Crawley SC, Li B, Chen HH, Malmersjö S, Sharkov NA, Horner G, Guo W, Kutach AK, Mondal K, Zhang Z, Lichtman JS, Song C, Rivera LB, Liu W, Luo J, Wang Y, Solloway M, Allan BB, Kekatpure A, Starck SR, Haldankar R, Fan B, Chu C, Tang J, Molgora M, Colonna M, Kaplan DD, and Hsu JY, Cancer Immunology Research, 2021 (Corresponding author)
• Antibody-mediated inhibition of GDF15-GFRAL activity reverses cancer cachexia in mice, Suriben R, Chen M, Higbee J, Oeffinger J, Ventura R, Li B, Mondal K, Gao Z, Ayupova D, Taskar P, Li D, Starck S, Chen HIH, McEntee M, Katewa SD, Phung V, Wang M, Kekatpure A, Lakshminarasimhan D, White A, Olland A, Haldankar R, Solloway MJ, Hsu JY, Wang Y, Tang J, Lindhout DA, Allan BB, Nature Medicine, 2020
• Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15, Hsu JY, Crawley S, Chen M, Ayupova DA, Lindhout DA, Higbee J, Kutach A, Joo W, Gao Z, Fu D, To C, Mondal K, Li B, Kekatpure A, Wang M, Laird T, Horner G, Chan J, McEntee M, Lopez M, Lakshminarasimhan D, White A, Wang SP, Yao J, Yie J, Matern H, Solloway M, Haldankar R, Parsons T, Tang J, Shen WD, Alice Chen Y, Tian H, Allan BB, Nature, 2017 (Co-corresponding author)
• Separating Tumorigenicity from Bile Acid Regulatory Activity for Endocrine Hormone FGF19, Zhou M, Wang X, Phung V, Lindhout DA, Mondal K, Hsu JY, Yang H, Humphrey M, Ding X, Arora T, Learned RM, Depaoli AM, Tian H, and Ling L, Cancer Research, 2014
• Restoration of euglycemia after duodenal bypass surgery is reliant on central and peripheral inputs in Zucker fa/fa rats, Jiao J, Bae EJ, Bandyopadhyay G, Oliver J, Marathe C, Chen M, Hsu JY, Chen Y, Tian H, Olefsky JM, and Saberi M, Diabetes, 2013
• Hsu JY, Juven-Gershon T, Marr II MT, Wright KJ, Tjian R, and Kadonaga JT. TBP, Mot1 and NC2 establish a regulatory circuit that controls DPE-dependent versus TATA-dependent transcription. Genes and Development, 2008.
• Hsu JY, Sun ZW, Li X, Reuben M, Tatchell K, Bishop DK, Grushcow JM, Brame CJ, Caldwell JA, Hunt DF, Lin R, Smith MM, Allis CD. Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes. Cell, 2000.

• Innovation Award, NGM Bio, 2015
• Post-doctoral Fellowship, Helen Hay Whitney Foundation, 2003-2006
• Studentship, Institute of Biomedical Sciences, Academia Sinica, Taiwan, 1993-1995
• The President’s Award, National Taiwan University, 1993

Innovation Award, NGM Bio 2015

Post-doctoral Fellowship, Helen Hay Whitney Foundation 2003-2006

Studentship, Institute of Biomedical Sciences, Academia Sinica, Taiwan 1993-1995

The President’s Award, National Taiwan University 1993