Arulmozhi Palani
Seattle,WA
Summary
Experienced biomedical researcher specializing in stem cell biology and CAR-T cell therapy with over 6 years in the field. Focused on creating innovative T cell immunotherapies for leukemia and multiple myeloma. Strong background in guiding research students and implementing practical applications in oncology and regenerative medicine.
Overview
8
8
years of professional experience
1
1
Certification
Work History
Research Tech II
Fred Hutch
Seattle, USA
11.2022 - Current
- Tissue culture of mammalian cell lines and patient-derived primary human cells (CD4+ and CD8+).
- Design and evaluation of sensitive chimeric T cell receptors (CAR T-cell therapy).
- Investigating the role of CD3 ITAMs-mediated signaling by the ch-TCRs.
Executive - Research and Development
Stempeutics Research Private Limited
Bengaluru
12.2020 - 11.2022
- Develop potency assays for the treatment of osteoarthritis
- Develop human allogeneic stem cell therapy product for the treatment of Critical Limb Ischemia and Osteoarthritis
- Prepare Standard Operating Procedures for the laboratory assays and equipment
- Create and manage documentation of reagent inventory and experimental data
Research Scholar
Vellore Institute of Technology
Vellore
01.2019 - 03.2020
- Characterized gram positive and gram negative bacteria from clinical isolates phenotypically and genotypically
- Isolated and purified endolysin gene from Enterobacter virus myPSH1140 infecting Enterobacter spp.
- Isolated and characterized therapeutic potential bacteriophages against multi-drug resistant gram negative bacteria
Project Assistant
Centre for Stem Cell Research (a Unit of InStem, Bengaluru), Christian Medical College
Vellore
09.2017 - 01.2019
- Treated osteochondral and segmental bone defects in goats using functionalized scaffolds, with or without allogeneic mesenchymal stem cells.
- Carried out mutation analysis of the WISP3 gene in the Indian population with progressive pseudorheumatoid dysplasia.
- Isolated and cultured chondrocytes from articular cartilage, and analyzed chondrocyte-specific gene expression on two-dimensional (monolayer) and three-dimensional substrates (chitosan and hyaluronic acid).
- Isolated and cultured muscle stem cells from rat gastrocnemius muscle.
- Isolated and cultured mesenchymal stem cells from human peripheral blood and bone marrow.
- Cultured cancer stem cells derived from patients with osteosarcoma.
Education
MSc - Biotechnology
Sri Ramachandra University
Chennai, India07.2017
BSc - Biotechnology
DKM College For Women
Vellore06.2015
Skills
- Mammalian cell culture
- Lentiviral transduction
- Gene editing: CRISPR and BE
- Flow cytometry and cell sorting
- PBMC and T cell isolation
- Cell-based assays: CTV, cytokine secretion, killing assay, restimulation assay, chromium release assay
- Incucyte, z-Movi, and Legendplex
- ELISA and Western blotting
- Immunohistochemistry techniques
- Mesenchymal stem cell culturing and differentiation
- DNA and RNA isolation and cloning
- Murine tissue processing
- Data analysis and Graphical representation with GraphPad PRISM
Certification
Certificate on Mycotechnology, Royal Bio Research Centre, 05/01/14
Invited Lectures
Antibiotics and Bacteriophages - Past, Present and Future, Alumni Meet 2019, Department of Biotechnology, DKM College for Women
Languages
- Tamil - Read, Write, Speak
- English - Read, Write, Speak
Publications
Simon, S., Bugos, G., Prins, R. et al. Design of sensitive monospecific and bispecific synthetic chimeric T cell receptors for cancer therapy. Nat Cancer 6, 647–665 (2025). https://doi.org/10.1038/s43018-025-00927-0
Antimicrobial Therapeutic Strategies for Enterococcus faecalis In Dental Infections - Past, Present and Future, Lokitha R., Nandakumar Namitha, Harish K., Arulmozhi P., Jayakumar Aarthi, Anbarasi K., Benedict Paul C., Anti-Infective Agents, 2023, 21, 3, e200123212930
Hobbies and Interests
- Watching movies
- Listening to music
- Browsing
Posters Presented
- International Conference on Environment and Health Sciences (ICEHS - 2020), Won 2nd prize
- Cloning and expression of the endolysin gene from Enterobacter virus myPSH1140 infecting Enterobacter spp., Department of Zoology, DKM College for Women, Vellore, 01/01/20
- 4th International Conference on Birth Defects (ICBD2018), Christian Medical College, Vellore, 10/01/18
- Organized 'International Conference on Bacteriophage Research and Antimicrobial Resistance', 12/01/19
- Participated in 'EMBL-EBI-IBAB Workshop on Analysis of Next-Generation Sequencing Data', 11/01/18, The Institute of Bioinformatics and Applied Biotechnology (IBAB), Bengaluru
Leadership Experience
- Guided 14 Master degree students for their research project
- Conducted Lab sessions for MSc Students
- Has been an examiner for internal and university examinations
Timeline
Research Tech II
Fred Hutch
11.2022 - Current
Executive - Research and Development
Stempeutics Research Private Limited
12.2020 - 11.2022
Research Scholar
Vellore Institute of Technology
01.2019 - 03.2020
Project Assistant
Centre for Stem Cell Research (a Unit of InStem, Bengaluru), Christian Medical College
09.2017 - 01.2019
MSc - Biotechnology
Sri Ramachandra University
BSc - Biotechnology
DKM College For Women
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