Ayan Ray

I have a mixed academic and industry experience developing innovative mouse models to investigate growth factor signaling mechanisms in human diseases, embryonic development, and cancer. Additionally, I have been instrumental in creating stable cell lines to support high-throughput screening (HTS) assays for deeper exploration of drug mechanisms. By integrating these approaches, I have leveraged large-scale data analysis to reveal how drug candidates modulate non-canonical signaling pathways often masked by biological redundancy. This combined strategy has been particularly effective in identifying key players and elucidating their effects on complex intracellular signaling networks, where traditional models have proven insufficient. I am passionate about developing high-throughput approaches, integrating cGMP workflows, that enable research in broad areas focused towards disease modeling and therapeutics.

• Enzo Life Sciences, Not Provided, Farmingdale, NY, 11735, Scientist II, 02/01/22, Current, Designed and standardized automated methods for HT reporter-based screening, enzyme assays, and immunoassay workflows achieving
• Icahn School of Medicine at Mount Sinai, New York, NY, 10029, Associate Scientist, 02/01/20, 02/01/22, Investigated the role of non-canonical growth factor signaling in embryonic development of epithelial organs. Executed diverse research initiatives including studies on elucidating mechanisms of pseudokinase function, moonlighting effects of RTK, fibroblast growth factor receptor activation, cell-basement membrane interactions and characterization of non-canonical intracellular signaling outputs, GTPases function. Established and maintained collaborative ventures with clinicians, senior investigators and postdoctoral fellows. Authored multiple scientific manuscripts as a first author and contributed to multi-year competitive RO1 grants.
• Icahn School of Medicine at Mount Sinai, New York, NY, 10029, Postdoctoral fellow, 02/01/15, 02/01/21, Advanced FGF signaling research in the context of craniofacial birth defects. Developed novel mouse models to characterize unique RTK signaling outputs that play crucial skeletal differentiation in neural crest derived stem cells.

• Icahn School of Medicine at Mount Sinai, New York, NY, 10029, Associate Scientist, 02/01/21, Current
• Icahn School of Medicine at Mount Sinai, New York, NY, 10029, Postdoctoral Research Scientist, 02/01/15, 02/01/21
• Indian Institute of Technology Kanpur, Kanpur, India, 208016, Ph.D., 02/01/09, 02/01/15
• Indian Institute of Technology Kanpur, Kanpur, India, 208016, M. Tech., 02/01/07, 02/01/09
• University of Pune, Pune, India, 411007, M.Sc., Microbiology, 02/01/05, 02/01/07
• University of Pune, Not Provided, Pune, India, 411007, B.Sc., Microbiology, 02/01/03, 02/01/05

• Ray A. T. and Philippe Soriano. FGF signaling regulates salivary gland branching morphogenesis by modulating cell adhesion. Development (2023) 150 (6): dev201293.
• Ray A. T., Mazot P., Brewer J.R., Catela C., Dinsmore C.J., Soriano P. FGF signaling regulates development by processes beyond canonical pathways. Genes and Development (2020) 34:1735-1752. (Recommended by Faculty 1000)
• Singh P.N.P., Shea C.A., Sonker S.K., Rolfe R.A., Ray A., Kumar S., Gupta P., Murphy P., and Bandyopadhyay A. Precise spatial restriction of BMP signaling in developing joints is perturbed upon loss of embryo movement. Development (2018) 145(5): dev153460. (Recommended by Faculty 1000)
• Ray A., Singh P., Sohaskey M.L., Harland R.M., and Bandyopadhyay A. Precise spatial restriction of BMP signaling is essential for articular cartilage differentiation. Development (2015) 142(6):1169-1179. (Recommended by Faculty 1000)
• Singh P.N.P., Ray A., Azad K., Bandyopadhyay A. A comprehensive mRNA expression analysis of developing chicken articular cartilage. Gene Expression Patterns (2015) 20(1): 22-31.
• Jaswal A.P., Ray A., and Bandyopadhyay A. Book Chapter: Etiology and treatment of Osteoarthritis: A developmental biology perspective. Regenerative Medicine: Laboratory to Clinic (2017): 17-42.

• Proven leadership in managing international and NIH funded projects, from conception through to execution and subsequent publications.
• Ability to collaborate across multidisciplinary teams, contributing to product development and drive research initiatives.
• Skilled in data analytics, with the ability to process and analyze large datasets using R, Python, and develop statistical workflows in PowerBi.
• Expertise in RNAseq and single-cell RNAseq (scRNAseq) data analysis, enabling in-depth exploration of gene expression and signaling pathways with GALAXY (galaxyproject.org) python and R.
• Communicating results and key findings have played a central role in my job. Contributed to developing SOPs and protocols and authored multiple peer-reviewed publications.
• Contributions to the understanding of RTK signaling in embryonic development and disease, with practical applications in the study of craniofacial birth defects.