Banzhan Ruan

Being a Postdoctoral Fellow from the University of Cincinnati, adept in bioinformatics and collaborative teamwork, significantly contributed to groundbreaking research in RNA modifications, acute pulmonary effusions and vascular tumor formation. Published in prestigious journals like Autophagy and Nat Commun, showcasing expertise in molecular biology and a commitment to advancing medical science.

• He was named an outstanding instructor for guiding college students to participate in the finals of the 7th National Undergraduate Basic Medical Innovation Research and Experimental Design Forum and won the national bronze medal.

• Science and Technology Planning Project of Guangdong Province, PC20052013, Studied on Alzheimer's disease., 2009-2010
• Fujian Health Education Joint Research Project, WKJ2008-2-40, Studied on human insulin production in Tremella bioreactor., 2010-2013
• National Natural Science Foundation, 31671432, 31770975, Studied on cell-in-cell formation in vivo and in vitro., 2014-2019
• Provincial Key Laboratory Open Project, JCKF2020001, Studied on the mechanism of cell-in-cell formation., 2020-2022
• Regional Youth Talent Innovation Fund, QCXM202017, Studied on protein metabolism in cell-in-cell structure., 2020-2023

• In 2023, he participated in the academic symposium of the School of Basic Medicine and Life Sciences of Hainan Medical University as the invited speaker.
• In 2022, he made a poster to participate in the Annual Symposium of University of Cincinnati Cancer Biology Department.

• Zheng Shaojiang; Zheng Liping; Zhang Xiaodian; Lu Yanda; Ruan Banzhan; Wang Bingshu; Chen Yan. A PD1 recombinant virus for a key FGFR1 and its application, Chinese invention patent, 2024.
• Sun Qiang; Wang Chenxi; Ruan Banzhan; Zhang Bo. A method for targeting ARHGAP36 to promote homogenous CIC formation and inhibit breast tumor growth, Chinese Invention Patent, 2023.

[1] Ruan B, Zhang B, Chen A, Yuan L, Liang J, Wang M, et, al. Cholesterol inhibits entotic cell-in-cell formation and actomyosin contraction. Biochem Biophys Res Commun. 2018 Jan 1;495(1):1440-1446.

[2] Ruan B, Wang C, Chen A, Liang J, Niu Z, Zheng Y, et, al. Expression profiling identified IL-8 as a regulator of homotypic cell-in-cell formation. BMB Rep. 2018 Jul 19. pii: 4178.

[3] Ruan B, Niu Z, Jiang X, Li Z, Tai Y, Huang H, et al. High Frequency of Cell-in-Cell Formation in Heterogeneous Human Breast Cancer Tissue in a Patient With Poor Prognosis: A Case Report and Literature Review. Front Oncol. 2019;9:1444. Published 2019 Dec 19. doi:10.3389/fonc.2019.01444.

[4] Ruan BZ, Xie BG. Analysis of codon bias and its application on the expression of foreign genes in fungi. JMBPGE. 2013,2(1): 1-18.

[5] Wang C#, Chen A#, Ruan B#, Niu Z, Su Y, Qin H, et al. PCDH7 Inhibits the Formation of Homotypic Cell-in-Cell Structure. Front Cell Dev Biol. 2020;8:329. Published 2020 May 8. doi:10.3389/fcell.2020.00329（Co-first author）

[6] Li S#, Ruan B#, Wang Z#, Xia J, Lin Q, Xu R, Zhu H, Yu Z. Glucose dysregulation promotes oncogenesis in human bladder cancer by regulating autophagy and YAP1/TAZ expression. J Cell Mol Med. 2023 Sep 4. doi: 10.1111/jcmm.17943. Epub ahead of print. PMID: 37665055.（Co-first author）

[7] Yang F, Kalantari S, Ruan B, Sun S, Bian Z, Guan JL. Autophagy inhibition prevents lymphatic malformation progression to lymphangiosarcoma by decreasing osteopontin and Stat3 signaling. Nat Commun. 2023 Feb 22;14(1):978. doi: 10.1038/s41467-023-36562-5

[8] Yu Y, Ding S, Xu X, Yan D, Fan Y, Ruan B, Zhang X, Zheng L, Jie W, Zheng S. Integrating Network Pharmacology and Bioinformatics to Explore the Effects of Dangshen (Codonopsis pilosula) Against Hepatocellular Carcinoma: Validation Based on the Active Compound Luteolin. Drug Des Devel Ther. 2023 Mar 1;17:659-673. doi: 10.2147/DDDT.S386941

[9] Xu X, Yu Y, Yang L, Wang B, Fan Y, Ruan B, Zhang X, Dai H, Mei W, Jie W, Zheng S. Integrated analysis of Dendrobium nobile extract Dendrobin A against pancreatic ductal adenocarcinoma based on network pharmacology, bioinformatics, and validation experiments. Front Pharmacol. 2023 Mar 1;14:1079539. doi: 10.3389/fphar.2023.1079539. eCollection 2023.

[10] Du L, Liu N, Jin J, Cao M, Sun Y, Gao X, Ruan B, Yang S, Ge D, Ye Y, Zhou Y, Chen E, Yang J. ZNF3 regulates proliferation, migration and invasion through MMP1 and TWIST in colorectal cancer. Acta Biochim Biophys Sin (Shanghai). 2022 Dec 25;54(12):1889-1896. doi: 10.3724/abbs.2022187

[11] Yi F, Cai C, Ruan B, Hao M, Yeo SK, Haas M, Yang F, Zhang X, Guan JL. Regulation of RB1CC1/FIP200 stability and autophagy function by CREBBP-mediated acetylation in an intrinsically disordered region. Autophagy. 2022 Nov 27:1-16. doi: 10.1080/15548627.2022.2148432

[12] Tang M, Su Y, Zhao W, Niu Z, Ruan B, Li Q, Zheng Y, Wang C, Zhang B, Zhou F, Wang X, Huang H, Shi H, Sun Q. AIM-CICs: an automatic identification method for cell-in-cell structures based on convolutional neural network. J Mol Cell Biol. 2022 Nov 26;14(6):mjac044. doi: 10.1093/jmcb/mjac044

[13] Su Y, Huang H, Luo T, Zheng Y, Fan J, Ren H, Tang M, Niu Z, Wang C, Wang Y, Zhang Z, Liang J, Ruan B, Gao L, Chen Z, Melino G, Wang X, Sun Q. Cell-in-cell structure mediates in-cell killing suppressed by CD44. Cell Discov. 2022 Apr 19;8(1):35. doi: 10.1038/s41421-022-00387-1.

[14] Liang J, Niu Z, Zhang B, Yu X, Zheng Y, Wang C, Ren H, Wang M, Ruan B, Qin H, Zhang X, Gu S, Sai X, Tai Y, Gao L, Ma L, Chen Z, Huang H, Wang X, Sun Q. p53-dependent elimination of aneuploid mitotic offspring by entosis. Cell Death Differ. 2021 Feb;28(2):799-813. doi: 10.1038/s41418-020-00645-3.

[15] Wang M, Niu Z, Qin H, Ruan B, Zheng Y, Ning X, et al. Mechanical Ring Interfaces between Adherens Junction and Contractile Actomyosin to Coordinate Entotic Cell-in-Cell Formation. Cell Rep. 2020;32(8):108071. doi:10.1016/j.celrep.2020.108071

[16] Deng Y, Huang X, Ruan B, Xie B, van Peer AF, Jiang Y. Optimal codons in Tremella fuciformis end in C/G, a strong difference with known Tremella species. World J Microbiol Biotechnol. 2015 Nov;31(11):1691-1698.