Summary
Overview
Work History
Education
Skills
Websites
Patents And Publications - Publications
Degree
Activities And Awards
Leadership Experience
Accomplishments
Affiliations
References
Timeline
Generic

Bhupinder Sandhu

San Diego

Summary

Accomplished Senior Scientist at Bristol Myers Squibb with expertise in solid-state characterization and formulation strategies. Proven ability to lead high-priority projects under pressure, utilizing advanced techniques like PXRD and DSC. Known for excellent communication skills and delivering impactful results in drug development, enhancing timelines and resource efficiency.

Overview

11
11
years of professional experience

Work History

SENIOR SCIENTIST, PREFORMULATION & ANALYTICAL SCIENCES

BRISTOL MYERS SQUIBB
San Diego
02.2022 - Current
  • Developed and implemented formulation strategies for poorly soluble small molecules, leveraging techniques such as particle size reduction, amorphous solid dispersions (ASD), and lipid-based formulations.
  • Led the design, characterization, and optimization of oral, IV, IP formulations to support in vivo pharmacology, DMPK, and toxicology studies.
  • Interpreted the impact of formulations (solution vs suspensions vs lipid vs ASD) on invivo studies and proposed appropriate follow-up studies with minimal guidance, applying scientific and regulatory knowledge.
  • Alignment with Drug product development focused on continued use of same formulation strategy in discovery tox and GLP tox studies to minimize resources and improve timelines.
  • Provided analytical and pharmaceutics expertise to allow smooth transitions for programs on aggressive timelines, with focus on high priority programs.
  • Performed selection and characterization of solid-state forms (e.g., amorphous vs crystalline, polymorphs/salt selection), including analytical techniques such as PXRD, DSC, TGA, DVS, microscopy, UPLC/HPLC, particle size analysis, and solubility/stability assessments.
  • Analytical method development for very greasy non soluble compounds to ensure chemical stability.
  • Utilized modeling capabilities such as gastroPlus to predict a priori need for enabling formulations such as ASD for toxicology studies.
  • Completed course on GMP : Tablet Manufacturing Technology Industry Certification, with specifics on blending, granulation, compression, coating, and quality control.

PREFORMULATION SCIENTIST, DRUG PRODUCT DEVELOPMENT

GOSSAMER BIO
San Diego
07.2021 - 02.2022
  • Conducted preformulation studies to assess the stability, compatibility, and processability of drug substance and drug products.
  • Evaluated API properties for solid-state characterization (e.g., XRD, DSC, TGA, FTIR).
  • Developed platform to grow single crystals to elucidate crystal structure which provided aid in the early candidate and final form selection.
  • Worked internally and with external partners (CROs and consultants) to help drive discovery and development projects.
  • Performed pre-formulation and formulation studies to drive medicinal chemistry programs to enable compound screening, conduct in-vivo studies.

SENIOR SCIENTIST, MATERIAL SCIENCE & ENGINEERING

BRISTOL MYERS SQUIBB
New Jersey
11.2018 - 06.2021
  • Provided solid state characterization support for portfolio projects to drive successful product development and meet project timelines. Generated and documented key data into regulatory documents including patent, NDA, and IND filing.
  • Supported solid state characterization for more than 100 small molecule intermediates and final products for discovery and development projects.
  • Performed solid state characterization of drug substances using various analytical techniques such as PXRD, TGA, VTI and DSC and understand structure property relationship and bulk behavior of API.
  • Designed and conducted crystallization and co-crystallization of small molecule portfolio to help improve physical stability, and hygroscopicity issues of key pharmaceutical products.
  • Designed and performed physical and chemical stability studies for drug substance and drug product.
  • Determined crystals structures of 70+ small molecules drug candidate and key intermediates and provided insight into structure-property relationships.
  • Maintained X-ray crystallography lab instruments and crystallization lab and coordinated with instrument vendors for troubleshooting and services.
  • Conducted form screening to understand polymorphism, hydrates and find the most suitable form for early candidate nomination.
  • Led crystal structure prediction (CSP) efforts within BMS to risk evaluate various polymorphs and nominate most stable thermodynamics form.
  • Acted as a liaison between BMS and CROs for technical and non-technical support, making key CSP timelines decisions based on project needs.

COLLABORATION

ELI LILLY & COMPANY/CCDC
Kansas State University
05.2016 - 05.2018
  • Developed a statistic logistic regression model to numerically evaluate and predict the crystallization tendencies of 50 drug like molecules.
  • Developed a statistic logistic regression model to predict the co-crystallization tendencies of small drug like molecules using variables such as molecular complementarity, propensity and thermodynamic energies of co-crystals.

SUMMER INTERNSHIP

BOEHRINGER INGELHEIM
Ridgefield
06.2014 - 08.2014
  • Conducted research on pharmaceuticals computer modeling to predict the morphology of small molecules and compared it to experimentally observed morphology in various organic solvents.
  • Performed multi-scale molecular modeling - dimer, cluster, surface chemistry, interfacial behavior.
  • Collected single crystal x-ray diffraction data, solved and refined crystal structures of the model compounds and updated the in-house crystallographic database using Prequest software.

Education

PH.D. - SOLID STATE CHEMISTRY

KANSAS STATE UNIVERSITY
KS
01.2018

B.S. - CHEMISTRY

NEW MEXICO HIGHLANDS UNIVERISTY
NM
01.2013

Skills

  • Powder X-ray diffraction (PXRD)
  • Single-crystal X-ray diffraction (SCXRD)
  • Differential scanning calorimetry (DSC)
  • Thermal Gravimetric Analysis (TGA)
  • Dynamic Light Scattering (DLS)
  • Amorphous spray dispersions (ASD)
  • Dynamic Vapor Sorption (DVS)
  • Hot stage microscopy
  • High-performance liquid chromatography (HPLC)
  • Nuclear Magnetic Resonance Spectroscopy (NMR)
  • Infrared spectroscopy (FT-IR)
  • Poised under pressure
  • Fun and energetic
  • Excellent interpersonal and communication skills

Patents And Publications - Publications

453, 14, https://scholar.google.com/citations?user=SBXWLtMAAAAJ&hl=en&oi=ao, Co-crystals of Nitroxyl donating compounds, 12841-WO-PCT, Submitted, 2024, Sandhu, B.; Sarjeant, A.; Using in silico Tools to Map the Structural Landscape of Nitroxyl (HNO donor) Compounds, 2021, Mandler, M.D.; Degnan, A.P.; Zhang, S.; Aulakh, D.; Georges, K.; Sandhu, B.; Sarjeant, A.; Zhu, Y.; Traeger, S.C.; Cheng, P.T.; Ellsworth, B.E.; Regueiro-Ren, A.; Structural and Thermal Characterization of Halogenated Azidopyridines: Under-Reported Synthons for Medicinal Chemistry, 2021, Oderinde, M.; Ramirez, A.; Dhar, T.G.M.; Cornelius, L.; Jorge, C.; Aulakh, D.; Sandhu, B.; Pawluczyk, J.; Sarjeant, A.; Meanwell, N.; Mathur, A.; Photocatalytic Dearomative Intermolecular [2 + 2] Cycloaddition of Heterocycles for Building Molecular Complexity, 2021, McDaniel, J.; Farley, C.A.; Ramirez, A.; Sandhu, B.; Sarjeant, A.; Shi, Q.; Han, A.; Gallagher, W.P.; Hynes Jr., J.; Dhar, T.G.M.; Gonzalez-Bobes, F.; Coombs, J.R; Marcoux, D.; Discovery of Annulating Reagents Enabling the One-Step and Highly Stereoselective Synthesis of Cyclopentyl and Cyclohexyl Cores, 2021, Sandhu, B.; McLean, A.; Sinha, A.S.; Desper, J.; Aakerӧy, C.B. Assessment of Computational Tools for Predicting Supramolecular Synthons, 2021, Shi, Q.; Greenwood, N. S.; Meehan, M. C.; Park, H.; Galella, M.; Sandhu, B.; Khandelwal, P.; Coombs, J. R.; Gallagher, W. P.; Guerrero, C. A.; Hynes, J.; Dhar, T. G. M.; Gonzalez Bobes, F.; Marcoux, D., One-Step Diastereoselective Pyrrolidine Synthesis Using a Sulfinamide Annulating Reagent, 2019, Sandhu, B.; Sinha, A. S.; Desper, J.; Aakeröy, C. B., Modulating the physical properties of solid forms of urea using cocrystallization technology, 2018, Sandhu, B.; McLean, A.; Sinha, A. S.; Desper, J.; Sarjeant, A. A.; Vyas, S.; Reutzel-Edens, S. M.; Aakeröy, C. B., Evaluating Competing Intermolecular Interactions through Molecular Electrostatic Potentials and Hydrogen-Bond Propensities, 2018, Getmanenko, Y. A.; Allen, T. G.; Kim, H.; Hales, J. M.; Sandhu, B.; Fonari, M. S.; Suponitsky, K. Y.; Zhang, Y.; Khrustalev, V. N.; Matichak, J. D.; Timofeeva, T. V.; Barlow, S.; Chi, S.-H.; Perry, J. W.; Marder, S. R., Linear and Third-Order Nonlinear Optical Properties of Chalcogenopyrylium-Terminated Heptamethine Dyes with Rigid, Bulky Substituents, 2018, Allen, T. G.; Getmanenko, Y. A.; Kim, H.; Hales, J. M.; Sandhu, B.; Fonari, M. S.; Suponitsky, K. Y.; Zhang, Y.; Khrustalev, V. N.; Matichak, J. D.; Timofeeva, T. V.; Barlow, S.; Chi, S.-H.; Perry, J. W.; Marder, S. R.; Nonlinear Optical Properties of Chalcogenopyrylium-Terminated Heptamethine Dyes in Multiple Polymer Hosts, 2017, Mohapatra, S. K.; Zhang, Y.; Sandhu, B.; Fonari, M. S.; Timofeeva, T. V.; Marder, S. R.; Barlow, S., Synthesis, characterization, and crystal structures of molybdenum complexes of unsymmetrical electron-poor dithiolene ligands, 2016, Alshehri, S.M., Tiwari, R.V., Alsulays, B.B., Ashour, E.A., Alshetaili, A.S., Almutairy, B., Park, J.M., Morott, J., Sandhu, B., Majumdar, S. Repka, M.; Investigation of the combined effect of MgO and PEG on the release profile of mefenamic acid prepared via hot-melt extrusion techniques, 2017, Khrustalev, V. N.; Sandhu, B.; Bentum, S.; Fonari, A.; Krivoshein, A. V.; Timofeeva, T. V., Absolute Configuration and Polymorphism of 2-Phenylbutyramide and α-Methyl-α-phenylsuccinimide, 2014, Getmanenko, Y. A.; Singh, S.; Sandhu, B.; Wang, C.-Y.; Timofeeva, T.; Kippelen, B.; Marder, S. R., Pyrrole[3,2-d:4,5-d']bisthiazole-bridged bis(naphthalene diimide)s as electron-transport materials, 2014, Thapa, S.; Draguta, S.; Sandhu, B.; Antipin, M. Y.; Timofeeva, T. V., 3, 4-Diaminopyridinium hydrogen Malonate, 2013, Sandhu, B.; Fonari, M. S.; Sawyer, K.; Timofeeva, T. V., A series of crystalline solids composed of aminopyridines and succinic, fumaric, and sebacic acids, 2013, Sandhu, B.; Draguta, S.; Kinnibrugh, T. L.; Khrustalev, V. N.; Timofeeva, T. V., Supramolecular synthesis based on piperidone derivatives and pharmaceutically acceptable co-formers, 2013, Sandhu, B.; Draguta, S.; Fonari, M. S.; Antipin, M.; Timofeeva, T. V., Pyridine-4-carbaldehyde-fumaric acid (2/1), 2013, Getmanenko, Y. A.; Polander, L. E.; Hwang, D. K.; Tiwari, S. P.; Galán, E.; Seifried, B. M.; Sandhu, B.; Barlow, S.; Timofeeva, T.; Kippelen, B.; Marder, S. R., Bis(naphthalene diimide) derivatives with mono- and dicarbonyl-fused tricyclic heterocyclic bridges as electron-transport materials, 2013, Getmanenko, Y. A.; Fonari, M.; Risko, C.; Sandhu, B.; Galán, E.; Zhu, L.; Tongwa, P.; Hwang, D. K.; Singh, S.; Wang, H.; Tiwari, S. P.; Loo, Y.-L.; Brédas, J.-L.; Kippelen, B.; Timofeeva, T.; Marder, S. R., Benzo[1,2-b:6,5b']dithiophene(dithiazole)-4,5-dione derivatives: synthesis, electronic properties, crystal packing and charge transport, 2013, Draguta, S.; Sandhu, B.; Khrustalev, V. N.; Fonari, M. S.; Timofeeva, T. V., Pyrimidine-2, 4-diamine acetone monosolvate, 2013, Draguta, S.; Khrustalev, V. N.; Sandhu, B.; Antipin, M. Y.; Timofeeva, T. V., 6-Methylpyridin-2-amine, 2012, Getmanenko, Y. A.; Risko, C.; Tongwa, P.; Kim, E.-G.; Li, H.; Sandhu, B.; Timofeeva, T.; Brédas, J.-L.; Marder, S. R., Mono- and Dicarbonyl-Bridged Tricyclic Heterocyclic Acceptors: Synthesis and Electronic Properties, 2011

Degree

Ph.D.

Activities And Awards

  • BMS BRAVO awards for passion, speed, integrity and accountability, Bristol-Myers Squibb, 2018-2022
  • Phi Lambda Upsilon (PLU) award for recognition of exceptional graduate research, Kansas State University, 2018
  • Graduate Award for Outstanding Leadership and Service, Kansas State University, 2018
  • International Leadership Award, Kansas State University, 2018
  • Best Oral Presentation Award, Midwest Organic Solid-State Chemistry Symposium (MOSSCS), 2017 & 2016
  • University Distinguished Professor Graduate Student Award, Kansas State University, 2017
  • William L. Richter International scholarship, recipient, Kansas State University, 2016
  • Graduate Student Research Award, Midwest Regional Meeting of the American Chemical Society (ACS), 2016
  • Phi Lambda Upsilon graduate classroom award for 4.0 cumulative GPA in the PhD program, Kansas State University, 2015
  • Outstanding Chemistry Graduate Student of the Year Award, New Mexico Highlands University, 2012
  • Robert Amai Chemistry Annual Award, New Mexico Highlands University, 2010

Leadership Experience

  • Active member, CLIMB, BOLD and B-NOW volunteering organizations, January 2019- Current
  • Reviewer, manuscripts in crystal growth and design, Reviewed 5 scientific publications from August 2018-Current
  • Committee member, Various committees, Co-chair of International student affairs committee, member of Research forum committee, Treasurer of Phi Lambda Upsilon society, Vice-president of Indian Student Association at Kansas State University.
  • Supervisor, Supervised the research (resulted in peer-reviewed publications) of three undergraduate students in graduate school, trained and managed one co-op student at Bristol Myers Squibb.

Accomplishments

· BMS BRAVO awards for passion, speed, integrity and accountability, Bristol-Myers Squibb, 2018-2022

· Phi Lambda Upsilon (PLU) award for recognition of exceptional graduate research, Kansas State University, 2018

· Graduate Award for Outstanding Leadership and Service, Kansas State University, 2018

· International Leadership Award, Kansas State University, 2018

· Best Oral Presentation Award, Midwest Organic Solid-State Chemistry Symposium (MOSSCS), 2017 &2016

· University Distinguished Professor Graduate Student Award, Kansas State University, 2017

· William L. Richter International scholarship, recipient, Kansas State University, 2016

· Graduate Student Research Award, Midwest Regional Meeting of the American Chemical Society (ACS), 2016

· Phi Lambda Upsilon graduate classroom award for 4.0 cumulative GPA in the PhD program, Kansas State University, 2015

· Outstanding Chemistry Graduate Student of the Year Award, New Mexico Highlands University, 2012

· Robert Amai Chemistry Annual Award, New Mexico Highlands University, 2010

Affiliations

· Active member of CLIMB, BOLD and B-NOW volunteering organizations, Bristol Myers Squibb, January 2019- Current.

· Reviewer of manuscripts in crystal growth and design, CrystEngComm, AAPS, molecules and crystals. Reviewed 5 scientific publications from august 2018-Current.

· Served on various committees: Co-chair of International student affairs committee, member of Research forum committee, Treasurer of Phi Lambda Upsilon society, Vice-president of Indian Student Association at Kansas State University.

· Supervised the research (resulted in peer-reviewed publications) of three undergraduate students in graduate school, trained and managed one co-op student at Bristol Myers Squibb.

References

References available upon request.

Timeline

SENIOR SCIENTIST, PREFORMULATION & ANALYTICAL SCIENCES

BRISTOL MYERS SQUIBB
02.2022 - Current

PREFORMULATION SCIENTIST, DRUG PRODUCT DEVELOPMENT

GOSSAMER BIO
07.2021 - 02.2022

SENIOR SCIENTIST, MATERIAL SCIENCE & ENGINEERING

BRISTOL MYERS SQUIBB
11.2018 - 06.2021

COLLABORATION

ELI LILLY & COMPANY/CCDC
05.2016 - 05.2018

SUMMER INTERNSHIP

BOEHRINGER INGELHEIM
06.2014 - 08.2014

PH.D. - SOLID STATE CHEMISTRY

KANSAS STATE UNIVERSITY

B.S. - CHEMISTRY

NEW MEXICO HIGHLANDS UNIVERISTY
Bhupinder Sandhu