Bibhuti Das

• Directed operations of a magnetic resonance research laboratory featuring advanced instrumentation.
• Oversaw preventive maintenance of equipment, implementing innovative strategies.
• Teamed up with research groups on NMR and EPR initiatives.
• Directed annual budget management to maintain efficient operations.

Directed management of $1M in funding to enhance efficiency of internal instrumentation including NMR, HPLC, SFC, UV/Vis, and LCMS systems.

Recruited and guided two analytical scientists, enhancing their skills in advanced analytical methods.

Hard Skills: Designed and implemented biophysical and analytical methods for protein stability assessment, and protein-small molecule interactions. Authored and reviewed laboratory protocols and over 30 technical reports on the structural and physicochemical characterization of drug-like substances, including Ksol, Tsol, pKa, LogD, forced degradation, and stability measurements.

· Soft Skills: Established a discovery analytical laboratory with the addition of a state-of-the-art 600 MHz Bruker NMR and Shimadzu analytical/preparative supercritical fluid (SFC) instrument for structure elucidation, biophysical discovery, and purification of chiral molecules-thus fostering collaborations in therapeutic areas such as uro-oncology, gastroenterology, regenerative medicine, and maternal health. Enhanced internal cross-departmental collaboration by developing and validating streamlined protocols for hit validation and lead optimization. Managed external collaboration with contract research service providers. Mentored and trained five Ph.D.-level junior scientists on analytical and biophysical workflows, improving efficiency and enabling rapid data-driven decision-making across teams.

· Hard Skills: Automated 1H and 19F NMR protocols (1D-STD, water-LOGSY, CPMG, 1H/13C/15N 2D-HSQC, HMQC, 3D-HNCACO, HNCACB, HNCOCA) for Fragment-Based Drug Discovery (FBDD) and validation using surface plasmon resonance (SPR) and differential scanning fluorometry (DSF), significantly increasing throughput for protein-protein and protein-small molecule interaction study. Designed and implemented solution quantitative NMR (1H, 13C, 15N, 19F 1D and 1H-13C 2D HSQC, HMBC, H2BC, COSY, NOESY, ROESY, DOSY) automation for rapid data acquisition and analysis of structures, solubility, and stability of fragment library and lead compounds.