Bishal Misra

Ph.D. candidate in Biomedical Sciences specializing in nanomaterial-based drug and vaccine development. Focus on designing and optimizing lipid-based nanoparticle formulations for RNA and adjuvant delivery. Proven track record merging formulation science, immunological assays, and analytical method development. Skilled in flow cytometry, HPLC, LC-MS, and confocal microscopy for analyzing biological responses and nanoparticle behavior. Dedicated to leveraging scientific innovation for next-generation therapeutics in pharmaceutical and biotechnology sectors.

• Misra B, Hughes KA, Pentz WH, Surface M, Geldenhuys WJ, Bobbala S. TLR7-Adjuvanted Ionizable Lipid Nanoparticles for mRNA Vaccine Delivery. AAPS J. 2025 Apr 25;27(4):80. doi: 10.1208/s12248-025-01073-2. PMID: 40281311.
• Boehm, D.T., Landreth, K.M., Kilic, E.S., Lee, K.S., Misra, B., Bobbala, S., Damron, F.H., Liu, T.W., 2025. Intratumoral administration of mRNA COVID-19 vaccine delays melanoma growth in mice. Scientific Reports 15.. https://doi.org/10.1038/s41598-025-89930-0.
• Westemeier-Rice, E. S.; Winters, M. T.; Rawson, T. W.; Patel, K. J.; McHugh, O.; Ward, S.; McLaughlin, S.; Stewart, A.; Misra, B.; Dziadowicz, S.; et al. Lnc-RAINY Regulates Genes Involved in Radiation Susceptibility Through DNA:DNA:RNA triplex-forming Interactions and has Tumor Therapeutic Potential in Lung Cancers. Non-coding RNA Research 2024. DOI: https://doi.org/10.1016/j.ncrna.2024.12.004.
• Misra B, Hughes KA, Pentz WH (2024) Flash nanoprecipitation assisted self-assembly of ionizable lipid nanoparticles for nucleic acid delivery. Nanoscale 16::6939–6948. https://doi.org/10.1039/d4nr00278d
• Hughes, K.A., Misra, B., Maghareh, M. et al. Flash nanoprecipitation allows easy fabrication of pH-responsive acetalated dextran nanoparticles for intracellular release of payloads. Discover Nano 19, 4 (2024). https://doi.org/10.1186/s11671-023-03947-w
• Misra, B., Hughes, K.A., Bobbala, S. (2023). Nano-Adjuvants. In: Patravale, V.B., Date, A.A., Jindal, A.B. (eds) Nanomedicines for the Prevention and Treatment of Infectious Diseases. AAPS Advances in the Pharmaceutical Sciences Series, vol 56. Springer, Cham. https://doi.org/10.1007/978-3-031-39020-3_10
• Hughes KA, Misra B, Maghareh M, et al. Use of stimulatory responsive soft nanoparticles for intracellular drug delivery. Nano Research, 2022, https://doi.org/10.1007/s12274-022-5267-5
• Gething, C., Ferrar, J., Misra, B., Howells, G., Andrzejewski, A.L., Bowen, M.E., Choi, U.B., 2022. Conformational change of Syntaxin-3b in regulating SNARE complex assembly in the ribbon synapses. Scientific Reports 12.. doi:10.1038/s41598-022-09654-3
• Gandhi, P.J., Gawande, D.Y., Shelkar, G.P., Gakare, S.G., Kiritoshi, T., Ji, G., Misra, B., Pavuluri, R., Liu, J., Neugebauer, V., Dravid, S.M., 2021. Dysfunction of Glutamate Delta-1 Receptor-Cerebellin 1 Trans-Synaptic Signaling in the Central Amygdala in Chronic Pain. Cells 10, 2644.. doi:10.3390/cells10102644

edX-

• edX Verified Certificate for Proteins: Biology's Workforce Issued Dec 2020, Credential ID a8d9e7f470b34ec2beb1f6461134070e
• edX Verified Certificate for BioStatistics
  Issued Jun 2020, Credential ID 8dfc399401424ad9a284827e01780e82

Nature masterclasses -

• Persuasive Grant Writing (July, 2023)
• Advancing your Scientific Presentations (July, 2023)
• Data Analysis: Conducting and Troubleshooting (June, 2023)
• Networking for Researchers (May, 2023)
• Interpreting Scientific Results (April, 2023)
• Narrative Tools for Researchers (Jan, 2023)
• Focus on Peer Review (Jan, 2023)
• Data Analysis: Planning and Preparing (Jan, 2023)

• "Adjuvanted Ionizable Lipid Nanoparticles for mRNA Delivery" international conference hosted by the American Association of Pharmaceutical Scientists (AAPS), October 2023
• "Ionizable Lipid Nanoparticles for Precise Intracellular Delivery of CpG DNA Adjuvant" international conference hosted by the American Association of Pharmaceutical Scientists (AAPS), October 2022
• "Conformational dynamics of SNARE recycling mediated by NSF " international conference hosted by the Biophysical Society (BPS), 2021
• "Modified Release of Microparticles for Pulmonary Drug Delivery" international conference hosted by the American Association of Pharmaceutical Scientists (AAPS), November 2017

• American Association of Indian Pharmaceutical Scientists (AAiPS) Graduate Student Award (October, 2023)
• AAPS Best Abstract Award (Abstract Title: Adjuvanted Ionizable Lipid Nanoparticles for mRNA Delivery (June, 2023)
• Robert E. Stitzel Graduate Student Award (April, 2023)
• Provisional patent - Ionizable and Cationic Lipid Nanoparticles For Intracellular Drug Delivery , US Provisional Patent Application Serial No. 63/512,423 (WVURC 2022-042) (July 7th, 2023)

• WVU Cell & Molecular Biology and Biomedical Engineering Training Program (CBTP), funded by NIGMS grant T32

      Associate Scholar

• Rho-chi society (Alpha Mu chapter at West Virginia University)

     Student Member

• Alpha Eta chapter of the Phi Lambda Sigma Leadership Society

     Student Member 

• "Adjuvanted Ionizable Lipid Nanoparticles for mRNA Delivery" international conference hosted by the American Association of Pharmaceutical Scientists (AAPS), October 2023
• "Ionizable Lipid Nanoparticles for Precise Intracellular Delivery of CpG DNA Adjuvant" international conference hosted by the American Association of Pharmaceutical Scientists (AAPS), October 2022
• "Conformational dynamics of SNARE recycling mediated by NSF " international conference hosted by the Biophysical Society (BPS), 2021
• "Modified Release of Microparticles for Pulmonary Drug Delivery" international conference hosted by the American Association of Pharmaceutical Scientists (AAPS), November 2017

• Patent - Ionizable and Cationic Lipid Nanoparticles For Intracellular Drug Delivery , PCT/US24/36890 (May 7th, 2024- under review)
• BioLegend CYTO 2024 Travel Award (April, 2024)
• Robert E. Stitzel Graduate Student Award (April, 2024)
• American Association of Indian Pharmaceutical Scientists (AAiPS) Graduate Student Award (October, 2023)
• AAPS Best Abstract Award (Abstract Title: Adjuvanted Ionizable Lipid Nanoparticles for mRNA Delivery (June, 2023)
• Robert E. Stitzel Graduate Student Award (April, 2023)

• WVU Cell & Molecular Biology and Biomedical Engineering Training Program (CBTP), funded by NIGMS grant T32

      Associate Scholar

• Rho-chi society (Alpha Mu chapter at West Virginia University)

     Student Member

• Alpha Eta chapter of the Phi Lambda Sigma Leadership Society

     Student Member 

• "Dual Adjuvanted Ionizable Lipid Nanoparticles for Vaccine Delivery" international conference hosted by the American Association of Pharmaceutical Scientists (AAPS), Salt Lake City, October 2024
• "Flash Nanoprecipitation Permits Self-assembly of Ionizable Lipid Nanoparticles for Nucleic Acid Delivery" international conference hosted by the American Association of Pharmaceutical Scientists (AAPS), San Francisco, May 2024 - Poster presentation and talk
• "Adjuvanted Ionizable Lipid Nanoparticles for mRNA Delivery" international conference hosted by the American Association of Pharmaceutical Scientists (AAPS), Orlando, October 2023
• "Ionizable Lipid Nanoparticles for Precise Intracellular Delivery of CpG DNA Adjuvant" international conference hosted by the American Association of Pharmaceutical Scientists (AAPS), Boston, October 2022
• "Conformational dynamics of SNARE recycling mediated by NSF " international conference hosted by the Biophysical Society (BPS), 2021
• "Modified Release of Microparticles for Pulmonary Drug Delivery" international conference hosted by the American Association of Pharmaceutical Scientists (AAPS), San Diego, November 2017

• Patent - Ionizable and Cationic Lipid Nanoparticles For Intracellular Drug Delivery , PCT/US24/36890 (May 7th, 2024- under review)
• BioLegend CYTO 2024 Travel Award (April, 2024)
• Robert E. Stitzel Graduate Student Award (April, 2024)
• American Association of Indian Pharmaceutical Scientists (AAiPS) Graduate Student Award (October, 2023)
• AAPS Best Abstract Award (Abstract Title: Adjuvanted Ionizable Lipid Nanoparticles for mRNA Delivery (June, 2023)
• Robert E. Stitzel Graduate Student Award (April, 2023)

• WVU Cell & Molecular Biology and Biomedical Engineering Training Program (CBTP), funded by NIGMS grant T32

      Associate Scholar

• Rho-chi society (Alpha Mu chapter at West Virginia University)

     Student Member

• Alpha Eta chapter of the Phi Lambda Sigma Leadership Society

     Student Member 

• "Dual Adjuvanted Ionizable Lipid Nanoparticles for Vaccine Delivery" international conference hosted by the American Association of Pharmaceutical Scientists (AAPS), Salt Lake City, October 2024
• "Flash Nanoprecipitation Permits Self-assembly of Ionizable Lipid Nanoparticles for Nucleic Acid Delivery" international conference hosted by the American Association of Pharmaceutical Scientists (AAPS), San Francisco, May 2024 - Poster presentation and talk
• "Adjuvanted Ionizable Lipid Nanoparticles for mRNA Delivery" international conference hosted by the American Association of Pharmaceutical Scientists (AAPS), Orlando, October 2023
• "Ionizable Lipid Nanoparticles for Precise Intracellular Delivery of CpG DNA Adjuvant" international conference hosted by the American Association of Pharmaceutical Scientists (AAPS), Boston, October 2022
• "Conformational dynamics of SNARE recycling mediated by NSF " international conference hosted by the Biophysical Society (BPS), 2021
• "Modified Release of Microparticles for Pulmonary Drug Delivery" international conference hosted by the American Association of Pharmaceutical Scientists (AAPS), San Diego, November 2017

• Patent - Ionizable and Cationic Lipid Nanoparticles For Intracellular Drug Delivery , PCT/US24/36890 (May 7th, 2024- under review)
• 2024 Outstanding Graduate Student Award, (April, 2024)
• BioLegend CYTO 2024 Travel Award (April, 2024)
• Robert E. Stitzel Graduate Student Award (April, 2024)
• American Association of Indian Pharmaceutical Scientists (AAiPS) Graduate Student Award (October, 2023)
• AAPS Best Abstract Award (Abstract Title: Adjuvanted Ionizable Lipid Nanoparticles for mRNA Delivery (June, 2023)
• Robert E. Stitzel Graduate Student Award (April, 2023)

• WVU Cell & Molecular Biology and Biomedical Engineering Training Program (CBTP), funded by NIGMS grant T32

      Associate Scholar

• Rho-chi society (Alpha Mu chapter at West Virginia University)

     Student Member

• Alpha Eta chapter of the Phi Lambda Sigma Leadership Society

     Student Member 

• "Dual Adjuvanted Ionizable Lipid Nanoparticles for Vaccine Delivery" international conference hosted by the American Association of Pharmaceutical Scientists (AAPS), Salt Lake City, October 2024
• "Flash Nanoprecipitation Permits Self-assembly of Ionizable Lipid Nanoparticles for Nucleic Acid Delivery" international conference hosted by the American Association of Pharmaceutical Scientists (AAPS), San Francisco, May 2024 - Poster presentation and talk
• "Adjuvanted Ionizable Lipid Nanoparticles for mRNA Delivery" international conference hosted by the American Association of Pharmaceutical Scientists (AAPS), Orlando, October 2023
• "Ionizable Lipid Nanoparticles for Precise Intracellular Delivery of CpG DNA Adjuvant" international conference hosted by the American Association of Pharmaceutical Scientists (AAPS), Boston, October 2022
• "Conformational dynamics of SNARE recycling mediated by NSF " international conference hosted by the Biophysical Society (BPS), 2021
• "Modified Release of Microparticles for Pulmonary Drug Delivery" international conference hosted by the American Association of Pharmaceutical Scientists (AAPS), San Diego, November 2017