Brendon Michael Patierno

My laboratory research experience has included preclinical studies, correlative science with archived clinical specimens, as well as specimen collection and analyses with a continued interest in translational science.

More recently I have expanded my knowledge to the genetic and molecular regulation of central nervous system development using the mammalian retina as a model. I have experience with identification of cis regulatory elements (CREs) through the analysis of evolutionarily conserved regions of genomic sequence as well as ATACseq and CHIP data, and subsequent characterization by cell lineage trace analysis. In vivo electroporation in the mouse retina has allowed me to induce cell fate changes during development and single cell RNAseq confirms the extent to which photoreceptor reprogramming has been initiated.

1. Patierno BM, Emerson MM; Multimodal analysis of Onecut1 induced cone photoreceptors in postnatal mice. Publication in process

2. Patierno BM, Emerson MM; Enhanced Transcriptional Activation in Developing Mouse Photoreceptors. Investigative Ophthalmology and Visual Science. 2025;66(1):54. https://doi.org/10.1167/iovs.66.1.54

3. Patierno BM, Foo WC, Allen T, Somarelli JA, Ware KE, Gupta S, Wise S, Wise JP Sr, Qin X, Zhang D, Xu L, Li Y, Chen X, Inman BA, McCall SJ, Huang J, Kittles RA, Owzar K, Gregory S, Armstrong AJ, George DJ, Patierno SR, Hsu DS, Freedman JA. Characterization of a castrate-resistant prostate cancer xenograft derived from a patient of West African ancestry. Prostate Cancer Prostatic Dis. 2022 Sep;25(3):513-523. doi: 10.1038/s41391-021-00460-y. Epub 2021 Oct 13. PMID: 34645983; PMCID: PMC9005588.

4. George DJ, Halabi S, Heath EI, Sartor AO, Sonpavde GP, Das D, Bitting RL, Berry W, Healy P, Anand M, Winters C, Riggan C, Kephart J, Wilde R, Shobe K, Rasmussen J, Milowsky MI, Fleming MT, Bearden J, Goodman M, Zhang T, Harrison MR, McNamara M, Zhang D, LaCroix BL, Kittles RA, Patierno BM, Sibley AB, Patierno SR, Owzar K, Hyslop T, Freedman JA, Armstrong AJ. A prospective trial of abiraterone acetate plus prednisone in Black and White men with metastatic castrate-resistant prostate cancer. Cancer. 2021 Aug 15;127(16):2954-2965. doi: 10.1002/cncr.33589. Epub 2021 May 5. PMID: 33951180; PMCID: PMC9527760.

5. Deveaux AE, Allen TA, Al Abo M, Qin X, Zhang D, Patierno BM, Gu L, Gray JE, Pecot CV, Dressman HK, McCall SJ, Kittles RA, Hyslop T, Owzar K, Crawford J, Patierno SR, Clarke JM, Freedman JA. RNA splicing and aggregate gene expression differences in lung squamous cell carcinoma between patients of West African and European ancestry. Lung Cancer. 2021 Mar;153:90-98. doi: 10.1016/j.lungcan.2021.01.015. Epub 2021 Jan 14. PMID: 33465699; PMCID: PMC8049647.

6. Robinson TJ, Freedman JA, Al Abo M, Deveaux AE, LaCroix B, Patierno BM, George DJ, Patierno SR. Alternative RNA Splicing as a Potential Major Source of Untapped Molecular Targets in Precision Oncology and Cancer Disparities. Clin Cancer Res. 2019 May 15;25(10):2963-2968. doi: 10.1158/1078-0432.CCR-18-2445. Epub 2019 Feb 12. PMID: 30755441; PMCID: PMC6653604.