Summary
Overview
Work History
Education
Skills
Honors and affiliations
Grants
Publications
Timeline
Generic
Bronson R. Weston

Bronson R. Weston

Dayton,USA

Summary

Dynamic computational biologist with a PhD and four years of hands-on experience in model, method, and product development. Skilled in solving complex problems and fostering collaboration across functional teams to address cross-disciplinary challenges. Possesses a deep understanding of molecular biology and a passion for driving innovation. Open to opportunities in model/method development or commercial roles, with a keen ability to build relationships and effectively communicate scientific insights to diverse audiences.

Overview

13
13
years of professional experience

Work History

Computational Biologist II

Asimov
02.2024 - Current
  • Leveraged modeling methods to Asimov’s cell line screening process to improve titers by an average of 15% across a diverse set of clones
  • Developed software to optimize media components to improve titer performance across various vessel scales, cell-lines and molecules
  • Functional liaison between the commercial team and the computational biology team at Asimov
  • All duties of Computational Biologist I

Computational Biologist I

Asimov
06.2022 - 02.2024
  • Led development of a CHO cell software platform, consisting of mechanistic and machine learning models, optimization algorithms and analysis tools to predict and optimize CHO cell behavior in a fed batch process
  • Developed regression models to predict product quality attributes from process design
  • Worked with experimental teams on agile projects to expedite delivery of key results
  • Managed relationship with external partners to evaluate new technologies for potential use at Asimov

Postdoctoral Research Fellow

National University of Ireland Galway
02.2021 - 06.2022
  • Development of an algorithm that runs on genome-scale metabolic models to identify optimal changes in nutrition to force desired shifts in metabolism
  • Developed a toolbox to simulate nutrition in personalized models of human-microbiome co-metabolism using FBA, FVA and other computational techniques
  • Worked with collaborators to optimize feed components in Chinese hamster ovary cells
  • Modeled host-microbiome co-metabolism in salmon and identify novel nutrients to add to aquaculture feeds

Engineering Consultant

MOVA Technologies
07.2020 - 08.2021
  • Analyzed and suggested solutions for design challenges for a next-generation pollutant filtration system

Graduate Research Assistant

Virginia Tech
09.2015 - 12.2020
  • Identified key transcription factors and cytokine signaling cascades in Granulocyte-Monocyte Progenitors to develop an ODE model of cellular differentiation in response to various combinations of cytokines
  • Designed an ODE model of the asymmetrical cell cycle of model organisms, Caulobacter crescentus
  • The model addresses multiple layers of regulation from the transcriptional level to post translational modifications and protein-protein interactions as well as spatial localization

Research Assistant

University of Delaware
08.2013 - 05.2014
  • Developed a conceptual model of the microbial dynamics of bacteria in the intestinal tract associated with autism
  • Derived equations to predict the behavior and interactions of microbes
  • Created an agent-based model of bacteria in the human microbiome and analyzed the effects of manipulating variables

Lab Technician

Innospec Fuel Specialties
01.2012 - 06.2012
  • Ran multiple tests on fuel samples (including extractions and gas chromatography), managed fuel sample inventory and lab notebooks

Education

Doctor of Philosophy - Genetics, Bioinformatics, and Computational Biology

Virginia Tech
Blacksburg, VA
12.2020

Bachelor of Chemical Engineering - Minor: Computer Science

University of Delaware
Newark, DE
05.2014

Skills

  • Molecular Biology
  • Research Management
  • Metabolic Pathway Analysis
  • Regression Analysis
  • Differential Equations
  • Mechanistic Modeling
  • Linear Programming
  • Problem-Solving
  • Teamwork and Collaboration
  • Strong Work Ethic
  • Python Coding
  • Critical Thinking

Honors and affiliations

  • MSCA Seal of Excellence, 03/01/21
  • MSCA Seal of Excellence, 03/01/20
  • 1st Place for Oral Presentation at the Graduate Research Assembly Research Symposium, 04/01/20
  • Graduate Student Representative for the VT University Advisory Council on Strategic Budgeting and Planning, 06/01/18 - 06/01/19
  • Graduate Student Representative for the VT Student Budget Board, 06/01/18 - 06/01/19
  • Director of Finance of the VT Graduate Student Assembly, 06/01/18 - 06/01/19
  • Vice-Chair of the VT Graduate Student Assembly Events Committee, 12/01/17 - 05/01/18
  • Graduate Student Assembly Travel Fund Program Award, 05/01/17
  • Attendee of the 10th Annual Q-Bio Summer School, 07/01/16
  • University of Delaware Presidential Scholarship, 2010-2014
  • Member of University of Delaware’s Honors Program, 2010-2014
  • University of Delaware’s General Honors Award, 2012
  • AP Scholar with Honor Award, 06/01/10

Grants

MSCA Postdoctoral Fellowship 2021, Investigating aspects of metabolism pertinent to atherosclerosis utilizing computational techniques., €199,694.40

Publications

  • Vera-Ponce de León, A., Hensen, T., Hoetzinger, M., Shashank G, Weston B, et al., 2024, Genomic and functional characterization of the Atlantic salmon gut microbiome in relation to nutrition and health., Nature Microbiology,
  • Weston BR and Thiele, I., 2023, A nutrition algorithm to optimize feed and medium composition using genome-scale metabolic models., Metabolic Engineering,
  • Law JN, Orbach S.M., Weston BR, Steele PA, Rajagopalan P. and Murali TM., 2023, Computational Construction of Toxicant Signaling Networks., Chemical Research in Toxicology,
  • Weston BR, Tyson JJ and Cao Y., 2021, Computational Models Reveal a New Role for Unphosphorylated CtrA in the Caulobacter Cell Cycle., iScience,
  • Xu C, Weston BR, Tyson JJ and Cao Y., 2020, Cell Cycle Control and Environmental Response by Second Messengers in Caulobacter crescentus., BMC Genomics,
  • Weston BR, Liwu L and Tyson JJ., 2018, Mathematical Analysis of Cytokine-Induced Differentiation of Granulocyte-Monocyte Progenitor Cells., Frontiers in Immunology
  • Lin C, Culver J, Weston B, Underhill E, Gorky J and Dhurjati P., 2018, GutLogo: Agent-based modeling framework to investigate spatial and temporal dynamics in the gut microbiome., PloS one
  • Weston B, Fogal B, Cook D and Dhurjati P., 2015, An Agent-Based Modeling Framework for Evaluating Hypotheses on Risks for Developing Autism: Effects of the Gut Microbial Environment., Medical Hypothesis

Timeline

Computational Biologist II

Asimov
02.2024 - Current

Computational Biologist I

Asimov
06.2022 - 02.2024

Postdoctoral Research Fellow

National University of Ireland Galway
02.2021 - 06.2022

Engineering Consultant

MOVA Technologies
07.2020 - 08.2021

Graduate Research Assistant

Virginia Tech
09.2015 - 12.2020

Research Assistant

University of Delaware
08.2013 - 05.2014

Lab Technician

Innospec Fuel Specialties
01.2012 - 06.2012

Bachelor of Chemical Engineering - Minor: Computer Science

University of Delaware

Doctor of Philosophy - Genetics, Bioinformatics, and Computational Biology

Virginia Tech
Bronson R. Weston