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ScientistSr. Research AssociateWork Type
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Open to relocation: Yes
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CARLOS R LOPEZ
San Diego,CA
Work Preference
Summary
Scientist I/Sr. Research Associate with 25 years combining 15 years of extensive experience in preclinical in vivo research and 10 years at Neuroscience drug discovery, with a strong background designing, executing, and interpreting animal studies to support therapeutic development monitored by PI's. Collaborate in developing strategic study pathways and milestones for IND candidates, including target engagement and efficacy studies. Conduct in vivo neuroscience experiments using appropriate animal models and transgenic mice. Perform behavioral assessments in accordance with study protocol and literature.
Proven ability to collaborate effectively with multidisciplinary teams and provide recommendations based on extensive hands-on research experience. Strong knowledge of animal welfare principles and IACUC regulations. Serves as a designated trainer and mentor for junior and new staff, providing technical guidance and supporting the development of best practices as described in SOP.
Extended expertise in Neuroscience using stereotaxic equipment (ICV), in vivo pharmacology, efficacy, toxicology, pharmacokinetics (PK), strong expertise in autoimmune disease model (EAE) on disease induction, dosing and scoring. Strong experience on multiple routes dosing (SC,PO,IP,IV), blood collection, tissue harvesting, necropsy, anesthesia, surgery support, and post-procedure monitoring. Experienced working in both GLP and non-GLP environments, executing protocols, collecting study raw data and managing ELN supporting preclinical research programs.
Overview
1
1
Language
1
1
Certification
26
26
years of professional experience
Work History
Scientist I / Preclinical In Vivo Research
Bristol Myers Squibb
San Diego, CA
08.2015 - Current
- Achievement in in vivo neuroscience studies through work on programs under established protocols and supervision. Animal handling, monitoring, and behavioral assessment w/rotarod, hanging wire, open field, and black box to evaluate motor function, anxiety, and movement. Conduct studies for target engagement, PK/PD, drug delivery systems, and efficacy for new molecules. Experience with stereotaxic procedures and intracranial (IC) and (ICV) in rodents, with post monitoring for behavioral toxicity assay application. Drug administration and dosing (PO, IV, IP, SQ), multiple blood collections, and sample processing. Thorough necropsies, brain dissections, perfusions, SC collection, and CSF collection. Compliance-based blood collection using retro-orbital, cheek/submandibular, cardiac, jugular, cephalic, saphenous, femoral vein. Proficient experimental autoimmune encephalomyelitis (EAE) model, disease induction, scoring, and dosing. Safe anesthesia induction and monitoring and post-procedure monitoring. Clear data tracking in Excel, accurate ELN and animal record maintenance, and Prism graph creation for PI presentations. Consistent monitoring of animal health and welfare in line with IACUC. Training in tissue processing, under PI supervision, for tissue homogenization, capillary depletion assays, and preparation of tissue samples for RNA extraction. Improved reproducibility and study quality by troubleshooting experimental issues. Orderly management of vivarium and laboratory supplies, equipment cleaning, work area organization, and animal ordering from approved vendors. Progress in neuroscience TRC collaboration through support of Receptos-to-Celgene-to-BMS transition and multidisciplinary research and development for new molecules. Notable contribution to Zeposia approval during Receptos-Celgene transition, supporting multidisciplinary effort for multiple sclerosis and ulcerative colitis treatment with FDA registration in October 2020 and launch in over 50 countries.
Senior Research Associate
BTS
San Diego, CA
05.2005 - 08.2015
- Executed preclinical pharmaceutical research studies in GLP and non-GLP environments, supporting a broad range of efficacy, PK, ADME, toxicology, oncology, and disease-model programs.
- Executed study protocols and maintained study documentation per established procedures and GLP requirements, ensuring compliance and data integrity.
- Led team of 4-8 research assistants, overseeing daily activities and fostering collaboration while managing record keeping, data collection, training, and study conduct.
- Conducted oncology xenograft studies, including, cell inoculation, tumor growth measurements, randomization, group assignment, dosing, and tumor/tissue collection.
- Assisted with murine collagen-induced arthritis (RA), experimental autoimmune encephalomyelitis (EAE), and inflammatory models (DTH).
- Performed dosing by IV, PO, SQ, IM, and IP routes across multiple laboratory species.
- Collected blood from small and large animal species using submandibular, retro-orbital, cardiac, jugular.
- Conducted serial blood collections via Jugular Vein and with JVC cannulas conducting on Rats.
- Conducted detailed clinical observations, and body-weight measurements.
- Worked extensively with nude mice, SCID mice, rats, guinea pigs, hamsters, rabbits, dogs, swine, and primates (NHP).
- Performed anesthesia induction, gas anesthesia monitoring, recovery, and administration of pain medication on all small and large species.
- Supported surgical procedures, anesthesia induction, monitoring, recovery, and pain management across multiple species.
- Performed canine dosing by PO, SQ, IV, and IM routes and supported continuous infusion studies using infusion pumps.
- Supported swine studies on wound healing and pharmacokinetics, including drug biodistribution, transdermal patch dosing, and tissue collection, contributing to research advancements.
- Performed tissue collection from swine and NHP.
- Conduct specialized studies involving DSI telemetry monitoring for QT prolongation in dogs.
Senior Laboratory Animal Technician
PERRY SCIENTIFIC
San Diego, CA
02.2001 - 05.2005
- Executed preclinical animal studies supporting pharmaceutical investigations conducted by research laboratories in Southern California.
- Supported pharmaceutical preclinical studies involving laboratory animals and executed study procedures according to approved research protocols.
- Reviewed study protocols and executed animal dosing via SQ, IM, IP, and IV routes.
- Monitored laboratory animals for health and ensured protocol compliance throughout studies.
- Prepared and administered test article concentrations according to study requirements.
- Collected biological samples, including skin, whole blood, plasma, serum, and tissues.
- Supported oncology studies involving propagation of cancer cells and inoculation into animals.
- Performed tumor measurements and monitored tumor growth throughout study periods.
Education
Bachelor of Science (B.S.) - Biochemical Engineering
INSTITUTO TECNOLÓGICO DE TIJUANA
Tijuana, B.C., Mexico06-1996
Skills
- In vivo research
- Preclinical research
- Animal handling
- Behavioral testing
- Pharmacokinetic studies
- PK PD analysis
- Tissue collection
- GLP standards
- Neurodegenerative disease models
Personal Information
Title: SCIENTIST I, Sr. RESEARCH ASSOCIATE | PRECLINICAL
Certification
- RALAT -Registered Animal Laboratory Animal Technician, AALAS 2006-2007,
Necropsy Workshop, San Diego AALAS, 2005,
Swine in Laboratory Sciences Workshop, Dr. Michael Swindle, University of South Carolina, 2008,
AALAS Member, 2009-2012
Publications and Posters:
- "Ozanimod (RPC1063) Potentially Confers Neuroprotective Benefit Through Modulation of S1PR1 on Astrocytes"
Kristen R. Taylor Meadows, Mohd Waseem Akhtar, Christiane Villescaz, Bryan Clemons, Carlos Lopez, Samantha Sawa-Ballweber, Kevin C. Dines, Gregory J. Opiteck, Fiona L. Scott, Julie V. Selkirk.
Presented at the ACTRIMS 2018 Forum; February 13, 2018; San Diego, California
- "ZEP-2020-050983 - Deconstructing the pharmacological contribution of sphingosine-1 phosphate receptors to mouse models of multiple sclerosis using the species selectivity of ozanimod, a dual agonist for human sphingosine-1 phosphate receptor subtypes 1 and 5"
Journal of Pharmacology and Experimental Therapeutics, Jul 28, 2021
- "Administration of an Anti-Interleukin-13 (IL-13) Antibody Significantly Attenuates Esophageal Eosinophilic Infiltration and Systemic Inflammation in an IL-33-Induced Mouse Model of Eosinophilic Esophagitis"
Kate L. Paget, Carlos R. Lopez, Stephanie E. Smith, Julia Oh, David M. Guimond, Iliana Ruiz, Kevin C. Dines, and Marcos W. Steinberg
Neurosciences TCoE, Celgene Corporation, San Diego, CA, USA
- "Oxazolone-Induced Delayed Type Hypersensitivity (DTH) Reaction in Adult Yucatan Pigs: Validation of the Model with Cyclosporine A (CsA)"
SAMER NUHAILY, SOONPIN YEI, CARLOS LOPEZ, FRANCESCA INCARDONA, HENRY J ESBER,AND BASSAM B DAMAJ
JOURNAL OF IMMUNOL 2009 182:137.39
ANIMAL MODEL & TECHNICAL EXPERIENCE
- Neurosciences
- Basic Test article formulations and drug calculations
- Brain harvesting, dissection, perfusion and PFA for histology
- BBB drug screening
- ICV injections for target engagements
- Neurodegenerative Disease Murine models (Alzheimers Disease AD, Parkinson Disease PD and Amyotrophic lateral sclerosis ALS)
- Behavioral studies for mice (Rotarod, Open field, Hanging wire, BlackBox)
- Electronic notebook and digital data entry for record keeping
- Autoimmune / Inflammatory Models
- Murine experimental autoimmune encephalomyelitis (EAE)
- Collagen-induced arthritis (RA)
- Delayed-type hypersensitivity (DTH)
- Inflammatory disease models (EoE, Asthma)
- Pharmacology
- Pharmacokinetics
- ADME
- Efficacy studies
- Toxicology
- Drug biodistribution
- Multiple time-point PK sampling
- Continuous infusion studies
- Surgical / Procedural
- Anesthesia induction and monitoring
- Analgesia and pain management
- Post-operative monitoring
- IV catheter placement
- Osmotic pump implantation
- Pellet implantation
- Minor surgical procedures
- Tissue and organ harvesting
- Necropsy
- Oncology
- Nude mouse xenograft models
- SCID mouse models
- Tumor cell propagation and inoculation
- Tumor measurement, growth tracking, randomization, and dosing
SPECIES EXPERIENCE
- Small Animals: Mice, rats, hamsters, rabbits
- Large Animals: Dogs, swine, non-human primates (NHP)
Languages
Spanish
Native/ Bilingual
Timeline
Scientist I / Preclinical In Vivo Research
Bristol Myers Squibb
08.2015 - Current
Senior Research Associate
BTS
05.2005 - 08.2015
Senior Laboratory Animal Technician
PERRY SCIENTIFIC
02.2001 - 05.2005
Bachelor of Science (B.S.) - Biochemical Engineering
INSTITUTO TECNOLÓGICO DE TIJUANA