Chris Adams
Brookline,NH
Summary
Accomplished Principle Engineer with expertise in plant operations, drug product development and manufacturing, facilities maintenance, and safety standards. Skilled in process, facility and equipment design, root cause analysis, and process improvement. Led implementation of lean manufacturing principles and managed multidisciplinary teams to achieve operational success in multi-product facilities. People manager focused on developing personnel, and delivering innovative engineering solutions.
Overview
32
32
years of professional experience
Work History
Principle Plant Engineer
PCI
Bedford, NH
01.2023 - Current
- Function as a technical expert on utilities, equipment, systems, and processes for cGMP facilities
- Drives key equipment, systems, and facility improvement projects, providing oversight of design, construction, testing, and turnover with responsibility for schedule and overall project performance
- Led troubleshooting of operations, developed preventative maintenance procedures, and maintained engineering documentation (commissioning, protocols, test plans, functional/detailed design, drawings) to ensure compliance and operational efficiency
- Established equipment specifications in standard documentation – User Requirements (URS), Functional Specification (FS), and Detail Design Specifications (DDS) to support project alignment and regulatory compliance
- Executes tasks, under the minimal direction of project/program managers, to complete design, engineering, construction, commissioning, and qualification for projects within schedule and budget constraints
- Developed project scopes, schedules, and budgets to facilitate timely and cost-effective project execution
Sr. MTS Engineer
LSNE
Bedford, NH
07.2018 - 01.2023
- Led technology transfer programs through all phases of biopharmaceutical lifecycle.
- Evaluated novel platform technologies applicable across multiple programs.
- Supported experimentation and manufacturing through development and pilot scale studies to optimize processes.
- Established technical support initiatives for cGMP operations in multi-product environments, enhancing compliance and productivity.
- Developed solutions to complex problems, ensuring alignment with organizational objectives.
- Interacted with manufacturing staff to troubleshoot issues and enhance operations.
- Mentored junior MTS Engineers and investigators, fostering skill development and knowledge transfer.
- Composed technical documents, including protocols and batch records for studies.
Principal
Sandbox BioSolutions
Brookline, NH
01.2016 - 07.2018
- Designed and executed methodologies to assess applicability of new technologies for biologics development and manufacturing, enhancing technology selection processes
- Advised customers on fit-for-purpose materials of construction and operational parameters for novel technologies, ensuring compliance with industry standards
- Provided SUT technology expertise to customers in developing and deploying SU/Hybrid SU/SS systems for media and buffer production, supporting biologics and bulk drug substance preparation
Partner, Director of Operations
PDS Sandbox
Hudson, NH
02.2014 - 01.2016
- Oversaw daily operations of 8500 sqft design and test facility, ensuring smooth workflow and resource allocation
- Led evaluation, testing, and implementation of new technologies into existing development and manufacturing processes, enhancing operational capabilities
- Cultivated client relationships, defined project scopes, and designed program plans, aligning services with client needs.
Associate Director, MTS
Shire HGT
Lexington, MA
05.2012 - 02.2014
- Led development group of 3 FTEs to address manufacturing excursions, respond to agency inquiries, and drive manufacturing process improvements
- Managed technology evaluation experiments to assess integration feasibility into ongoing development programs
- Coordinated Cell Culture experiments to advance departmental development goals
Associate Director, Pilot Operations
Shire HGT
Lexington, MA
11.2008 - 05.2012
- Designed and managed an 8700 sqft. mammalian cell-based pilot plant for a dual train, vial to vial, production of therapeutic proteins and antibodies utilizing highly innovative SU Bioreactor and support systems
- Facilitated technical transfers from pilot scale to cGMP facilities, ensuring seamless transition and compliance with regulatory standards.
- Collaborated with cross-functional teams, including purchasing, facilities, manufacturing, regulatory, and QA/QC, to ensure delivery of quality molecules for patient treatment.
Sr. Manager, Bioreactor Operations
Shire HGT
Cambridge, MA
01.2007 - 11.2008
- Specified and installed cutting edge, integrated Bioreactor platform resulting in better process control and integrated data acquisition by introducing a Delta V-based platform layered with an OSI Pi database, providing increased data security and functionality
- Reorganized upstream process development operations group to enhance experimental efficiency through team-based approach and work tracking matrix
- Led PD department IS integration and new technologies team to automate data analysis with custom VB-based data entry and plotting sheets
Bioprocess Engineer IV, PD
Curagen Coproration
Branford, CT
09.2001 - 01.2007
Sr. Technical Engineer, Tech Services
Hamilton
North East Territory
09.2000 - 09.2001
Automation Specialist, HTS
Aventis
Bridgewater, NJ
10.2000 - 09.2001
Sr. Technical Engineer, Tech Services
Perkin Elmer/Packard Bio
NJ Territory
09.1999 - 09.2000
Associate Research Scientist I & II, HTS
Bristol-Myers Squibb
Connecticut/New Jersey
06.1994 - 09.1998
Education
Executive MBA - Mastering the Business of Science
Babson College Executive Education
Wellesley, MA01.2009
GMP Certificate -
University of Connecticut
Storrs, CT01.2006
BS - Liberal Studies (CS/MIS)
SCSU
New Haven, CT05-1996
Skills
- Process Engineering expert
- Equipment specification and design
- Process optimization
- Technical documentation
- cGMP compliance
- Formulation and Fill Finish
- Project management
- Multi-product facility builds
Affiliations
ISPE 2008
Timeline
Principle Plant Engineer
PCI
01.2023 - Current
Sr. MTS Engineer
LSNE
07.2018 - 01.2023
Principal
Sandbox BioSolutions
01.2016 - 07.2018
Partner, Director of Operations
PDS Sandbox
02.2014 - 01.2016
Associate Director, MTS
Shire HGT
05.2012 - 02.2014
Associate Director, Pilot Operations
Shire HGT
11.2008 - 05.2012
Sr. Manager, Bioreactor Operations
Shire HGT
01.2007 - 11.2008
Bioprocess Engineer IV, PD
Curagen Coproration
09.2001 - 01.2007
Automation Specialist, HTS
Aventis
10.2000 - 09.2001
Sr. Technical Engineer, Tech Services
Hamilton
09.2000 - 09.2001
Sr. Technical Engineer, Tech Services
Perkin Elmer/Packard Bio
09.1999 - 09.2000
Associate Research Scientist I & II, HTS
Bristol-Myers Squibb
06.1994 - 09.1998
Executive MBA - Mastering the Business of Science
Babson College Executive Education
GMP Certificate -
University of Connecticut
BS - Liberal Studies (CS/MIS)
SCSU