CLAYMORE GUMBO
Morgantown
Summary
Translational neuroscience PhD candidate specializing in traumatic brain injury (TBI), cerebrovascular dysfunction, and neurocardiac regulation. Expertise in designing and executing longitudinal preclinical studies that integrate in vivo functional imaging, cardiac phenotyping, and mechanistic neuroinflammatory analysis. Proven track record in evaluating therapeutic interventions, including exercise and pharmacologic modulation, through clinically relevant endpoints. Ready to leverage extensive background in a Translational Neuroscience Scientist role within the industry to drive advancements in CNS therapeutic development.
Overview
6
6
years of professional experience
1
1
Certification
Work History
Doctoral Researcher
West Virginia University
Morgantown, WV
08.2023 - Current
- Lead investigator on translational studies evaluating mechanisms of cerebrovascular dysfunction and cardiac injury following traumatic brain injury.
- Designed and executed multi-arm preclinical studies examining the impact of TBI and chronic cerebral hypoperfusion on cardiac function.
- Established longitudinal echocardiographic assessment pipeline to quantify acute and chronic ventricular remodeling.
- Implemented laser speckle contrast imaging to evaluate cerebrovascular reactivity under pharmacologic challenge.
- Identified associations between insular neuroinflammation and downstream cardiac dysfunction.
- Conducted therapeutic intervention studies testing moderate treadmill exercise and β1-adrenergic blockade.
- Analyzed complex longitudinal datasets using mixed-effects modeling and multi-factor ANOVA.
- Achieved recognition through first-authored and co-authored peer-reviewed publications.
- Presented impactful research findings at national conferences, fostering collaboration and knowledge sharing.
- Supervised and trained undergraduate research assistants in surgical and imaging methodologies.
Research Assistant
Wenzhou Medical University
Wenzhou, China
10.2021 - 05.2023
- Investigated the role of FGF21 in cardiovascular disease within a pharmaceutical sciences research program.
- Conducted experimental studies examining molecular and cardiovascular endpoints.
- Performed statistical analyses and data interpretation.
- Contributed to research reports and scientific presentations.
- Maintained laboratory equipment and ensured protocol compliance.
- Conducted literature reviews to support ongoing research projects and ensure comprehensive understanding of current findings.
- Analyzed data using statistical software, ensuring accuracy and reliability in research findings.
- Mentored junior research assistants, fostering skill development and promoting best practices in research methodology.
Hospital Pharmacy Intern
Wenzhou First Affiliated Hospital
Wenzhou, China
01.2020 - 01.2021
- Evaluated and ensured medication effectiveness and safety to enhance patient care in hospital settings.
- Performed pharmacokinetic analyses and assessed anticoagulation levels to support effective treatment plans.
- Engaged in interdisciplinary rounds to enhance clinical decision-making through accurate drug information provision.
- Performed comprehensive assessments of sterile compounding competencies to uphold quality and safety protocols.
- Assisted pharmacists in preparing and dispensing medications in compliance with safety regulations.
- Conducted medication reconciliations to ensure accuracy and reduce errors during patient transitions.
Education
Ph.D. - Pharmaceutical and Pharmacological Sciences
West Virginia University
Morgantown, WV05-2028
Bachelor of Science - Pharmacy
Wenzhou Medical University
Wenzhou, China01-2021
Skills
- Preclinical translational research models
- Rodent models of neurological disease (including TBI and BCAS chronic hypoperfusion)
- Acute and chronic disease phenotyping
- Sex-inclusive, multifactorial experimental design
- In vivo imaging and functional assessment (eg, echocardiography, laser speckle imaging)
- Autonomic and cardiovascular physiology analysis
- Histological and mechanistic tissue analysis
- Neuroinflammation and brain region–specific pathology profiling
- Quantitative morphometric and fibrosis analysis
- Pharmacology and therapeutic evaluation in vivo
- Chronic drug delivery systems (eg, osmotic minipumps) and dose-response studies
- Biostatistics and data analysis (GraphPad Prism, SPSS)
Affiliations
Member, American Association of Pharmaceutical Scientists (AAPS), 2026
Certification
- American Physiological Society (APS) Reviewer Certificate Program, 2026
Timeline
Doctoral Researcher
West Virginia University
08.2023 - Current
Research Assistant
Wenzhou Medical University
10.2021 - 05.2023
Hospital Pharmacy Intern
Wenzhou First Affiliated Hospital
01.2020 - 01.2021
Ph.D. - Pharmaceutical and Pharmacological Sciences
West Virginia University
Bachelor of Science - Pharmacy
Wenzhou Medical University
PUBLICATIONS
- Gumbo, C.T., et al. Traumatic brain injury impairs cardiac function independent of chronic cerebral hypoperfusion. American Journal of Physiology-Heart and Circulatory Physiology. 2026;330(3):H697–H707.
- Karelina, K., et al. Aerobic training improves exercise capacity after traumatic brain injury in female, but not male, mice. Frontiers in Physiology. 2025;16:1700462.
- Barbour, M.A., et al. Traumatic brain injury persistently increases the incidence of ischemic and hemorrhagic strokes: Potential mechanisms. Progress in Neurobiology. 2025;248:102749.
Conference Presentations
- ·Traumatic brain injury impairs cardiovascular function independent of preexisting cerebral hypoperfusion, Gumbo, C., Society for Neuroscience Annual Meeting, San Diego, CA, 2025, Poster Presentation.
- ·Traumatic brain injury impairs cardiovascular function independent of preexisting cerebral hypoperfusion, Gumbo, C., Van Liere and WV IDeA Research Conference, Morgantown, WV, 2025, Poster Presentation.
HONORS & AWARDS
- Zhejiang Provincial Government Scholarship (2020),
- Second Prize Poster Presentation Award – 6th Annual Pharmacy Academic Forum (2019)