Cristina Sánchez de Diego

Accomplished Scientist with a robust background at the University of Wisconsin-Madison, adept in leading groundbreaking research in immunotherapies for bone metastasis. Expert in project leadership and molecular biology, with a track record of securing funding and fostering interdisciplinary collaborations. Proven ability to mentor and advance personalized medicine, demonstrating significant achievements in bioengineering and clinical applications.

0000-0002-0905-1213

University of Wisconsin-Madison (2021-current)

• Mentor for Medical Scientist Training Program (MSTP)
• PI for Bios 152
• Mentoring 4 undergraduate student in different research based courses

University of Barcelona (2016-2021)

• Delivering lectures about CRISPR/Cas9 for Dentistry Bachelor Degree
• Delivering practical sessions of Molecular Biology in Medicine and Biomedicine Bachelor degrees.
• Assisting with program development and student evaluation
• Coordination and assessment of student work groups
• Delivering practical sessions of Molecular Biology in Medicine and Biomedicine Bachelor degrees.
• Implementing teaching Innovation techniques (eg. Flipping the classroom, Cajun-style teaching).

• Member, ASBMR social media committee, 01/01/22, present
• Member, Topical Advisory Panel of Molecular Immunology Section for MPDI, 01/01/23, present
• Guest editor, Recent Molecular Advances in the Pathology and Therapeutics of Musculoskeletal Disease in IJMS, 01/01/24, present

• Best postdoctoral talk Immunology Seminar of University of Wisconsin-Madison.
• Ayudas para la formacion del profesorado universitario (FPU) PhD fellowship by Ministerio de Educacion (Spain)
• Ayudas de Movilidad UZNorteamérica /Asia /Oceanía, by the University of Zaragoza

• Driving licence

• P220125US01 - DEVICE AND METHOD FOR CONTROLLING AND CONFIGURING THE SPACIAL AND TEMPORAL EVOLUTION OF A GRADIENT IN A MICROFLUIDIC ENVIRONMENT

• Ayuso, J. M., Farooqui, M., Virumbrales-Muñoz, M., Denecke, K., Rehman, S., Schmitz, R., Guerrero, J. F., Sanchez-de-Diego, C., Campo, S. A., Maly, E. M., Forsberg, M. H., Kerr, S. C., Striker, R., Sherer, N. M., Harari, P. M., Capitini, C. M., Skala, M. C., & Beebe, D. J. (2023b). Microphysiological model reveals the promise of memory-like natural killer cell immunotherapy for HIV± cancer. Nature Communications, 14(1), 6681. https://doi.org/10.1038/s41467-023-41625-8
• Sanchez-de-Diego, C., Virumbrales-Muñoz, M., Hermes, B., Juang, T. D., Juang, D. S., Riendeau, J., Guzman, E. C., Reed-McBain, C. A., Abizanda-Campo, S., Patel, J., Hess, N. J., Skala, M. C., Beebe, D. J., & Ayuso, J. M. (2023). Griddient: a microfluidic array to generate reconfigurable gradients. Communications Biology, 6(1), 925. https://doi.org/10.1038/s42003-023-05282-3
• Sanz-Serrano, D., Mercade, M., Ventura, F., & Sánchez-de-Diego, C. (2024). Engineering a Microphysiological Model for Regenerative Endodontic Studies. Biology, 13(4). https://doi.org/10.3390/BIOLOGY13040221
• Sanz-Serrano, D., Sánchez-de-Diego, C., Mercade, M., & Ventura, F. (2023). Dental Stem Cells SV40, a new cell line developed in vitro from human stem cells of the apical papilla. International Endodontic Journal, 56(4), 502–513. https://doi.org/10.1111/IEJ.13887
• Sethakorn, N., Heninger, E., Sánchez-de-Diego, C., Ding, A. B., Yada, R. C., Kerr, S. C., Kosoff, D., Beebe, D. J., & Lang, J. M. (2022). Advancing treatment of bone metastases through novel translational approaches targeting the bone microenvironment. Cancers, 14(3), 757. https://doi.org/10.3390/cancers14030757
• Simitian, G., Virumbrales-Muñoz, M., Sánchez-de-Diego, C., Beebe, D. J., & Kosoff, D. (2022). Microfluidics in vascular biology research: a critical review for engineers, biologists, and clinicians. Lab on a Chip, 22(19), 3618–3636. https://doi.org/10.1039/d2lc00352j
• Pedrazza, L., Martinez-Martinez, A., Sánchez-de-Diego, C., Valer, J. A., Pimenta-Lopes, C., Sala-Gaston, J., Szpak, M., Tyler-Smith, C., Ventura, F., & Rosa, J. L. (2023). HERC1 deficiency causes osteopenia through transcriptional program dysregulation during bone remodeling. Cell Death & Disease, 14(1), 17. https://doi.org/10.1038/s41419-023-05549-x
• Pimenta-Lopes, C., Sánchez-de-Diego, C., Deber, A., Egea-Cortés, A., Valer, J. A., Alcalá, A., Méndez-Lucas, A., Esteve-Codina, A., Rosa, J. L., & Ventura, F. (2023). Inhibition of C5AR1 impairs osteoclast mobilization and prevents bone loss. Molecular Therapy: The Journal of the American Society of Gene Therapy, 31(8), 2507–2523. https://doi.org/10.1016/j.ymthe.2023.04.022
• Roig-Soriano, J., Sánchez-de-Diego, C., Esandi-Jauregui, J., Verdés, S., Abraham, C. R., Bosch, A., Ventura, F., & Chillón, M. (2023). Differential toxicity profile of secreted and processed α-Klotho expression over mineral metabolism and bone microstructure. Scientific Reports, 13(1), 4211. https://doi.org/10.1038/s41598-023-31117-6
• Sánchez-de-Diego, C., Artigas, N., Pimenta-Lopes, C., Valer, J. A., Torrejon, B., Gama-Pérez, P., Villena, J. A., Garcia-Roves, P. M., Rosa, J. L., & Ventura, F. (2019). Glucose restriction promotes osteocyte specification by activating a PGC-1α-dependent transcriptional program. IScience, 15, 79–94. https://doi.org/10.1016/j.isci.2019.04.015
• Valer, J. A., Sánchez-de-Diego, C., Gámez, B., Mishina, Y., Rosa, J. L., & Ventura, F. (2019). Inhibition of phosphatidylinositol 3-kinase α (PI3Kα) prevents heterotopic ossification. EMBO Molecular Medicine, 11(9), e10567. https://doi.org/10.15252/emmm.201910567
• Valer, J. A., Sánchez-de-Diego, C., Pimenta-Lopes, C., Rosa, J. L., & Ventura, F. (2019). ACVR1 function in health and disease. Cells (Basel, Switzerland), 8(11), 1366. https://doi.org/10.3390/cells8111366
• Sánchez-de-Diego, C., Pedrazza, L., Pimenta-Lopes, C., Martinez-Martinez, A., Dahdah, N., Valer, J. A., Garcia-Roves, P., Rosa, J. L., & Ventura, F. (2021). NRF2 function in osteocytes is required for bone homeostasis and drives osteocytic gene expression. Redox Biology, 40(101845), 101845. https://doi.org/10.1016/j.redox.2020.101845
• Sánchez-de-Diego, C., Valer, J. A., Pimenta-Lopes, C., Rosa, J. L., & Ventura, F. (2019). Interplay between BMPs and reactive oxygen species in cell signaling and pathology. Biomolecules, 9(10), 534. https://doi.org/10.3390/biom9100534
• Felices, M. J., Escusol, S., Martinez-Beamonte, R., Gascón, S., Barranquero, C., Sanchez-de-Diego, C., Osada, J., & Rodríguez-Yoldi, M. J. (2019). LPS-squalene interaction on D-galactose intestinal absorption. Journal of Physiology and Biochemistry, 75(3), 329–340. https://doi.org/10.1007/s13105-019-00682-8
• Mármol, I., Sánchez-de-Diego, C., Jiménez-Moreno, N., Ancín-Azpilicueta, C., & Rodríguez-Yoldi, M. J. (2017). Therapeutic applications of Rose hips from different Rosa species. International Journal of Molecular Sciences, 18(6). https://doi.org/10.3390/ijms18061137
• Mármol, I., Sánchez-de-Diego, C., Pradilla Dieste, A., Cerrada, E., & Rodriguez Yoldi, M. J. (2017). Colorectal carcinoma: A general overview and future perspectives in colorectal cancer. International Journal of Molecular Sciences, 18(1), 197. https://doi.org/10.3390/ijms18010197
• Mármol, I., Sánchez-de-Diego, C., Pradilla Dieste, A., Cerrada, E., & Rodriguez Yoldi, M. J. (2017). Colorectal carcinoma: A general overview and future perspectives in colorectal cancer. International Journal of Molecular Sciences, 18(1), 197. https://doi.org/10.3390/ijms18010197
• Mármol, I., Virumbrales-Muñoz, M., Quero, J., Sánchez-de-Diego, C., Fernández, L., Ochoa, I., Cerrada, E., & Yoldi, M. J. R. (2017). Alkynyl gold(I) complex triggers necroptosis via ROS generation in colorectal carcinoma cells. Journal of Inorganic Biochemistry, 176, 123–133. https://doi.org/10.1016/j.jinorgbio.2017.08.020
• Horna-Terrón, E., Pradilla-Dieste, A., Sánchez-de-Diego, C., & Osada, J. (2014). TXNDC5, a newly discovered disulfide isomerase with a key role in cell physiology and pathology. International Journal of Molecular Sciences, 15(12), 23501–23518. https://doi.org/10.3390/ijms151223501