DEWAN SHRESTHA

A research professional with strong background in academic research and data-driven analysis. Proven ability to contribute to impactful research projects and adapt to evolving research needs. Known for collaborative spirit and consistent focus on achieving project goals. Proficient in statistical analysis, laboratory techniques, and academic writing.

• Genomics and epigenetics guided identification of tissue-specific genomic safe harbors, Shrestha, D., Bag, A., Wu, R. et al., Genome Biol, 23, 199, 2022, https://doi.org/10.1186/s13059-022-02770-3

Contribution: I primarily focused on developing a pipeline using Python to filter various genomic parameters for

identifying GSH sites. Additionally, I collected and curated data from public resources necessary for the

project. Besides that, I was also responsible for analyzing RNA-Seq data and contributing significantly to

drafting the manuscript

• Transcription factor 4 is a key mediator of oncogenesis in neuroblastoma by promoting myc activity, Aljouda, N. A., Shrestha, D., DeVaux, C., Olsen, R. R., Alleboina, S., Walker, M., Cheng, Y., & Freeman, K., Molecular Oncology, 2024, https://doi.org/10.1002/1878-0261.13714

Contribution: My primary responsibility in this project involved processing and analyzing NGS data, including

RNA-Seq, ATAC-Seq, and ChIP-Seq, along with data management and visualization. I also contributed in

writing specific sections regarding data analysis of the methods of the manuscript.

• Dynamic CTCF binding directly mediates interactions among cis-regulatory elements essential for hematopoiesis, Qi, Q., Cheng, L., Tang, X., He, Y., Li, Y., Yee, T., Shrestha, D., Feng, R., Xu, P., Zhou, X., Pruett-Miller, S., Hardison, R. C., Weiss, M. J., & Cheng, Y., Blood, 137, 10, 1327-1339, 2021, https://doi.org/10.1182/blood.2020005780

Contribution: My role in this project mainly focused on motif sequence analysis and data visualization and

representation.

Genome-wide identification and characterization of insulator elements, Qian Q., Shrestha D., Minzhang Z., Zhijun M., Tang X., Sheng Z., Cheng Y.

Contribution: I mainly focused on the processing and analysis of NGS data such as ATAC-Seq, ChIP-

Seq, PRO-Seq etc. Additionally, I also played a key role in training machine learning regression models

using Scikit-learn. I was also responsible for collecting and cleaning data from public resources, managing

and visualizing data. Currently, I am working on manuscript preparation.

• International Conference on Intelligent Biology and Medicine (ICIBM), Tampa, FL, 07/16/23 - 07/19/23, Poster presentation
• 8th Annual International Biology and Medicine Conference, Memphis, TN, 04/29/22, Poster presentation
• 16th Annual Bioinformatics Conference, Birmingham, AL, 03/28/19 - 03/30/19, Attendee
• UTEP/NMSU joint workshop, University of Texas at El Paso, 2016, Poster presentation
• Fifth Annual UTEP Graduate School Research Expo, 11/13/15, Volunteer