Dharaniya Sakthivel

• Studying the role of Nucleophosmin 1 mediated Caspase-2 activation in Acute Myeloid leukemia.
• Identified the potential mechanism by which cell death effectors regulate chemoresistance and chemosensitivity of leukemic cells.
• Developed and implemented translational strategies, mechanism of action hypotheses, and biomarker analysis plans for hematological malignancies.
• Acquired expertise in cancer immunology, immunophenotyping, cell therapy, and tumor microenvironment.
• Gained a deep understanding of multicolor flow cytometric techniques, CRISPR, IHC/IF, microscopy, and transcriptomic data analysis.
• Evaluated the role of Src inhibitors in the treatment of triple negative breast cancer.
• Selected as BRASS early graduate student scholarship finalist.
• Product Development- Designed and validated 3D-printed micro-well meshes to image highly mobile suspension cells.
• Awarded predoctoral training grant by CPRIT- chosen as the top 5 research idea among 100 applications.
• Awarded travel grant by CPRIT.
• Received Honorable Mention award for best poster presentation at the Annual DLDCCC Symposium.
• Invited to give a talk about the novel findings in the current project at 12 national and 1 international conference at Fiuggi, Italy.
• Served as a Judge for the Texas Medical Center Micro-World imaging contest.
• Mentored SMART program students.
• Published two first-author manuscripts.
• Awarded prize for the featured book chapter on nucleolus and cell cycle by Elsevier publishing house.

• Coordinating 5 different clinical trails to treat Sickle Cell Disease.
• Worked with principal investigator and sponsors to facilitate daily trial activities and comply with research protocols.
• Maintained compliance with protocols covering patient care and clinical trial operations.

Competitive Landscape and Market Segmentation analysis for an early-stage life science company, rBio focusing on human insulin production.

• Studied systemic regulators of Skeletal Muscle Regeneration.
• Tested the efficacy of using prolyl hydroxylase domain -2 inhibitor in improving skeletal muscle regeneration in obese and geriatric patients.
• Published 12 original manuscripts and review articles in a short span of 2.5 years.
• Awarded research grant as principal investigator by the Brigham Research Institute.
• Awarded Excellence in Surgery Research by Harvard Council.
• Delivered scientific talk at the Harvard Stem Cell Institute Annual Retreat
• Recruited and oversaw personnel to achieve performance and quality targets.
• Built successful project plans covering objectives, resources, and staffing to meet schedules.
• Quickly learned new skills and applied them to daily tasks, improving efficiency and productivity.
• Obtained needed resources by strategically negotiating with stakeholders and outside suppliers.

Established TET-OFF-3G based inducible expression system to study Ezrin receptor activation in Diffuse Large B-cell lymphoma.

Optimized the dose concentrations of several clinically approved drugs to test the sensitivity of different breast cancer cell lines.