Dingani Nkosi, MBBS, PhD
Houston,TX
Overview
7
7
years of professional experience
4
4
Certifications
Work History
Graduate Research Assistant
Florida State University, Department of Biomedical Sciences
08.2016 - 06.2020
Visiting Scholar/Research Assistant
Florida State University, Department of Biomedical Sciences
12.2013 - 08.2016
Education
Ph.D. - Biomedical Sciences
Florida State University
Tallahassee, FL06.2020
M.D. - Medicine
University of Malawi, College of Medicine
Blantyre, Malawi 05.2011
Certification
Anatomical and Clinical pathology board certification
Awards
Association of Molecular Pathology, Underrepresented in Medicine Travel Award, 2022, ASCP Annual Meeting Travel Grant, 2022, Randolph L. Rill Award for outstanding senior graduate student, Florida State University, Department of Biomedical Sciences, 2020, Travel award, International Society for Extracellular Vesicles (ISEV) & Metastasis Research Society (MRS) Joint Meeting, 2018, Randolph L. Rill Award for outstanding junior graduate student Florida State University, Department of Biomedical Sciences, 2018, Carl Storm Underrepresented Minority Fellowship, Gordon Research Seminar on Extracellular Vesicles, 2018, Center for Research, Education and Training Enhancement Fellowship (CREATE), Florida Agricultural & Mechanical University (FAMU), 2016-2020, Premedical Science Scholarship by National AIDS Commission of Malawi, University of Malawi, College of Medicine, 2005
Affiliations
- American Board of Pathology
- United States and Canadian Academy of Pathology (USCAP)
- College of American Pathologists (CAP)
- Society of Black Pathologists (SBP)
- Society for Hematopathology
- Association for Molecular Pathology (AMP)
- International society of extracellular vesicles (ISEV)
- Malawi medical council
Publications
- Neil, A.J., Nkosi, D., Yoon, J.-Y., Kolin, D.L. and Sholl, L.M. (2025), Molecular and immunohistochemical characterization of ERBB2 activating mutations in low-grade serous ovarian carcinoma. Histopathology, 87: 310-320. https://doi.org/10.1111/his.14552
- Zhu B, Bai Y, Yeo YY, Lu X, Rovira-Clavé X, Chen H, Yeung J, Nkosi D, Glickman J, Delgado-Gonzalez A, Gerber GK, Angelo M, Shalek AK, Nolan GP, Jiang S. A multi-omics spatial framework for host-microbiome dissection within the intestinal tissue microenvironment. Nat Commun. 2025 Jan 31;16(1):1230. doi: 10.1038/s41467-025-56237-7. PMID: 39890778; PMCID: PMC11785740.
- Yeo YY, Chang Y, Qiu H, Yiu SPT, Michel HA, Wu W, Jin X, Kure S, Parmelee L, Luo S, Cramer P, Lee JL, Wang Y, Yeung J, Ahmar NE, Simsek B, Mohanna R, Van Orden M, Lu W, Livak KJ, Li S, Shahryari J, Kingsley L, Al-Humadi RN, Nasr S, Nkosi D, Sadigh S, Rock P, Frauenfeld L, Kaufmann L, Zhu B, Basak A, Dhanikonda N, Chan CN, Krull J, Cho YW, Chen CY, Lee JYJ, Wang H, Zhao B, Loo HL, Kim DM, Boussios V, Zhang B, Shalek AK, Angelo M, Mahmood F, Ma Q, Burack WR, Signoretti S, Schürch CM, Hodi FS, Burack WR, Rodig SJ, Ma Q, Jiang S. Same-Slide Spatial Multi-Omics Integration Reveals Tumor Virus-Linked Spatial Reorganization of the Tumor Microenvironment. bioRxiv [Preprint]. 2024 Dec 22:2024.12.20.629650. doi: 10.1101/2024.12.20.629650. PMID: 39764057; PMCID: PMC11706242.
- Nkosi D, Crowe WE, Altman BJ, Oltvai ZN, Giampoli EJ, Velez MJ. SATB2 is an Emergent Biomarker of Anaplastic Thyroid Carcinoma and Correlates with Clinical Outcomes. Endocr Pathol. 2024 Dec;35(4):432-441. doi: 10.1007/s12022-024-09833-0. Epub 2024 Nov 5. PMID: 39499447; PMCID: PMC11695438.
- Yeo YY, Qiu H, Bai Y, Zhu B, Chang Y, Yeung J, Michel HA, Wright K, Shaban M, Sadigh S, Nkosi D, Shanmugam V, Rock P, Tung YJ, SPT Cramer P, Paczkowska J, Stephan P, Liao G, Huang AY, Wang H, Chen H, Frauenfeld L, Mitra B, Gewurz BE, Schürch CM, Zhao B, Nolan GP, Zhang B, Shalek AK, Angelo M, Mahmood F, Ma Q, Burack WR, Shipp MA, Rodig SJ, Jiang S. Epstein-Barr Virus Orchestrates Spatial Reorganization and Immunomodulation within the Classic Hodgkin Lymphoma Tumor Microenvironment. bioRxiv [Preprint]. 2024 Mar 7:2024.03.05.853886. doi: 10.1101/2024.03.05.853886. PMID: 38496566; PMCID: PMC10942289.
- Nkosi D, Allbee AW, Rothberg PG, Friedberg JW, Evans AG. Common clonal origin of three distinct hematopoietic neoplasms in a single patient: B-cell lymphoma, T-cell lymphoma, and polycythemia vera. Cold Spring Harb Mol Case Stud. 2024;9(4):a006313. Published 2024 Jan 10. doi:10.1101/mcs.a006313
- Nkosi D, George GV, Liu H, Pulido M, Velez MJ, Oltvai ZN. Efficient Lung Cancer Molecular Diagnostics by Combining Next Generation Sequencing with Reflex Idh1a Genefusion Assay Testing. Genes. 2023; 14(8):1551. https://doi.org/10.3390/genes14081551
- Ahmad A, Nkosi D, Iqbal MA. PARK2 Microdeletion or Duplications Have Been Implicated in Different Neurological Disorders Including Early Onset Parkinson Disease. Genes. 2023; 14(3):600. https://doi.org/10.3390/genes14030600
- Yuan X, Sun L, Jeske R, Nkosi D, York SB, Liu Y, Grant SC, Meckes DG Jr, Li Y. Engineering extracellular vesicles by three-dimensional dynamic culture of human mesenchymal stem cells. J Extracell Vesicles. 2022 Jun;11(6):e12235. doi: 10.1002/jev2.12235. PMID: 35716062; PMCID: PMC9206229.
- Nkosi D, Miller CA, Jajosky AN, Oltvai ZN. Incidental discovery of acute myeloid leukemia during liquid biopsy of a lung cancer patient. Cold Spring Harb Mol Case Stud. 2022 Jun 22;8(4):a006201. doi: 10.1101/mcs.a006201. PMID: 35732498; PMCID: PMC9235846
- Nkosi D, Casler VL, Syposs CR, Oltvai ZN. Utility of Select Gene Mutation Detection in Tumors by the Idylia Rapid Multiplex PCR Platform in Comparison to Next-Generation Sequencing. Genes. 2022; 13(5):799. https://doi.org/10.3390/genes13050799
- Nkosi D, Zent CS, El Hussein S. Persistent polyclonal B-cell lymphocytosis: Illustration of the great mimicker of low-grade B-cell lymphoma. eJHaem. 2022; 1– 2. https://doi.org/10.1002/jha2.436
- Cheerathodi M, Nkosi D, Cone AS, York SB, Meckes DG Jr. Epstein-Barr Virus LMP1 Modulates the CD63 Interactome. Viruses. 2021 Apr 15;13(4):675. doi: 10.3390/v13040675. PMID: 33907272; PMCID: PMC8071190.
- Nkosi D, Sun L, Duke LC, Meckes DG Jr. Epstein-Barr virus LMP1 manipulates the content and functions of extracellular vesicles to enhance metastatic potential of recipient cells. PLoS Pathog. 2020 Dec 31;16(12):e1009023. doi: 10.1371/journal.ppat.1009023. PMID: 33382850; PMCID: PMC774862.
- Nkosi D, Sun L, Duke LC, Patel N, Surapaneni SK, Singh M, Meckes DG Jr. Epstein-Barr Virus LMP1 Promotes Syntenin-1- and Hrs-Induced Extracellular Vesicle Formation for Its Own Secretion to Increase Cell Proliferation and Migration. mBio. 2020 Jun 16;11(3): e00589-20. doi: 10.1128/mBio.00589-20. PMID: 32546618; PMCID: PMC7298708.
- Nkosi D, Howell LA, Cheerathodi MR, Hurwitz SN, Tremblay DC, Liu X, Meckes DG Jr. Transmembrane Domains Mediate Intra- and Extracellular Trafficking of Epstein-Barr Virus Latent Membrane Protein 1. J Virol. 2018 Aug 16;92(17):e00208-18. doi: 10.1128/JVI.00208-18. PMID: 29950415; PMCID: PMC6096814.
- Rider MA, Cheerathodi MR, Hurwitz SN, Nkosi D, Howell LA, Tremblay DC, Liu X, Zhu F, Meckes DG Jr. The endosome sorting of EBV LMP1 evaluated by proximity-based BioID approach. Virology. 2018 Mar; 516:55-70. doi: 10.1016/j.virol.2017.12.033. Epub 2018 Jan 9. PMID: 29392079; PMCID: PMC5826876.
- Hurwitz SN, Cheerathodi MR, Nkosi D, York SB, Meckes DG Jr. Tetraspanin CD63 Bridges Autophagic and Endosomal Processes To Regulate Exosomal Secretion and Intracellular Signaling of Epstein-Barr Virus LMP1. J Virol. 2018 Feb 12;92(5):e01969-17. doi: 10.1128/JVI.01969-17. PMID: 29212935; PMCID: PMC5809724.
- Hurwitz SN, Nkosi D, Conlon MM, York SB, Liu X, Tremblay DC, Meckes DG Jr. CD63 Regulates Epstein-Barr Virus LMP1 Exosomal Packaging, Enhancement of Vesicle Production, and Noncanonical NF-κB Signaling. J Virol. 2017 Feb 14;91(5):e02251-16. doi: 10.1128/JVI.02251-16. PMID: 27974566; PMCID: PMC5309960.
- Nkosi D, Amare M. Atypical Presentation of Follicular Lymphoma: A Series of Unusual Clinical Case Reports. 2015 May 26; 25(5):531.
- Masamba L, Nkosi D, Kumiponjera D. Case report: Down-staging locally advanced head and neck cancer in an HIV infected patient in a limited resource setting. Malawi Medical Journal : the Journal of Medical Association of Malawi. 2013 Jun;25(2):53-55. PMID: 24098832; PMCID: PMC3784938.
- Nkosi, D. (2020). Mechanisms of Ebstein Barr Virus Encoded Latent Membrane Protein 1(LMP1) Trafficking to Extracellular Vesicles and Tumor Microenvironment Remodeling. Retrieved from https://purl.lib.fsu.edu/diginole/2020_Summer_Fall_Nkosi_fsu_0071E_15958.
- Nkosi D, Jajosky AN, Oltvai ZN. Incidental discovery of acute myeloid leukemia during liquid biopsy of a lung cancer patient. Platform presentation at Association of Molecular Pathology Annual Meeting, digital experience. November 2021.
- Nkosi D, Sun L, Meckes DG. Epstein - Barr virus LMP1 reorganize content and functions of the EVs to enhance metastatic potential of recipient cells. Platform presentation at Exosomes in Human Infectious Diseases Conference. Bahamas. February 2020.
- Nkosi D, Cheerathodi M, Rider MA, Meckes DG. Epstein-Barr virus LMP1 hijacks the host ESCRT machinery for exosomal secretion. Platform presentation at Gordon Research Conference on Extracellular Vesicles, Newry, ME. August 2018.
- Nkosi D, Cheerathodi M, Rider MA, Meckes DG. Epstein-Barr virus LMP1 hijacks the host ESCRT machinery for exosomal secretion. Platform presentation at International Conference on EBV & KSHV, Madison, WI. July 2018.
- Nkosi D, Syposs C, Evans AE, Burack WR. Transformation of T-LGL to Anaplastic LCL. Platform presentation at 16th Annual Hematology/Hematopathology symposium, Waterloo, NY. June 3, 2023.
- Nkosi D. Mechanisms of Epstein-Barr virus latent membrane protein 1 trafficking to extracellular vesicles and tumor microenvironment remodeling. University of Rochester Medical Center, Department of Pathology & Laboratory Medicine Research in Progress Conference. March 2021.
- Nkosi D. Extracellular vesicle and particle biomarkers define multiple human cancers. University of Rochester Medical Center, Department of Pathology Grand Rounds. April 2021
- Nkosi D, Howell L, Cheerathodi M, Hurwitz S, Tremblay D, Meckes DG. Epstein-Barr virus LMP1 extracellular vesicle sorting is mediated by the N-terminus and Transmembrane domains. 1st Annual Biomedical Sciences Retreat, Tallahassee, FL. October 2016
- Nkosi D, Giampoli E, Velez M. SATB2 Expression in Anaplastic Thyroid Carcinoma: A Novel Sensitive Ancillary Marker?. United States and Canadian academy of pathology annual meeting, New Orleans, LA. March 2023.
- Nkosi D, Buldo M, Liu H, Oltvai Z. Rapid Assessment of Kinase Gene Fusions Using the Idylia GeneFusion Assay in Lung Adenocarcinoma. Association of Molecular Pathology Annual Meeting, Phoenix, AZ, November 2022
- Nkosi D, Iqbal MA. Diverse presentation of PARK2 gene variant patients: Array CGH study of nine cases with PARK2 disruption. American College of Medical Genetics and Genomics annual clinical genetics meeting, Nashville, TN. March 2022.
- Nkosi D, Carter SC, Kostelic M, Grisafi1 J, Liu X, Meckes DG. Epstein - Barr virus Latent Membrane Protein 1 (LMP1) reorganizes the cargo and function of extracellular vesicles. The First Joint Conference on Extracellular Vesicles in Cancer; Nashville, TN. August 2019.
- Nkosi D, Cheerathodi M, Rider MA, Meckes DG. Epstein-Barr virus LMP1 hijacks the host ESCRT machinery for exosomal secretion. 2018 Gordon Research Conference on Extracellular Vesicles, Newry, ME. August 2018.
- Nkosi D, Cheerathodi M, Rider MA, Meckes DG. Epstein-Barr virus LMP1 hijacks the host ESCRT machinery for exosomal secretion. 2018 International Conference on EBV & KSHV, Madison, WI. July 2018.
- Nkosi D, Howell L, Cheerathodi M, Hurwitz S, Tremblay D, Meckes DG. Epstein-Barr virus LMP1 extracellular vesicle sorting is mediated by the N-terminus and Transmembrane domains. International Society for Extracellular Vesicle, Toronto, Canada. May 2017.
POST-DOCTORAL TRAINING
- Molecular Genetic Pathology fellowship, UT MD Anderson cancer center 7/1/2025 - 6/30/2026
- Hematopathology Fellowship, Mass General Brigham 7/1/2024 - 6/30/2025
- Resident Physician, Anatomical and Clinical Pathology, University of Rochester Medical Center 7/1/2020 - 6/30/2024
- Resident Medical Doctor, Oncology Unit, Queen Elizabeth Central Hospital, Blantyre, Malawi 11/1/2012 - 04/2013
- Intern Medical Doctor, Queen Elizabeth Central Hospital, Blantyre, Malawi 6/1/2011 - 10/12/2012
EDUCATIONAL CONTRIBUTIONS
- Medical students
- Instructor, Disease Processes & Therapeutics course and student pathology electives. University of Rochester School of Medicine. Course director: Jennifer Findeis-Hosey MD, Vice Chair of Education.
- Research mentor, 1st year students during summer research fellowships, Florida State University, College of Medicine
- Research mentor, research laboratory rotations and honors research thesis, Florida State University, College of Medicine
- Teaching Assistant, Physiology and Anatomy, Malawi College of Health Sciences
- Anatomy Dissection Instructor, University of Malawi, College of Medicine.
- Course director: Professor B. Msamati, Head of Anatomy department
Timeline
Graduate Research Assistant
Florida State University, Department of Biomedical Sciences
08.2016 - 06.2020
Visiting Scholar/Research Assistant
Florida State University, Department of Biomedical Sciences
12.2013 - 08.2016
Ph.D. - Biomedical Sciences
Florida State University
M.D. - Medicine
University of Malawi, College of Medicine
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