Disha Nitin Joshi
Princeton,NJ
Summary
An outcome focused analytical scientist with hands-on experience in quality control testing, HPLC-MS, sample analysis and looking for full-time opportunities as an analytical professional in quality control, preclinical and clinical research, biotechnology, oncology. Equipped with strong problem-solving abilities, willingness to learn, and excellent communication skills.
Overview
2
2
years of professional experience
Work History
Analytical Scientist II
Syneos Health
07.2024 - Current
- Processing and extraction of biological compounds in serum, plasma and other biological matrixes as per GLP, ICH compliance.
- Quality control testing of over 500 clinical and preclinical samples through ESI-MS, HPLC-MS.
- Method development and validation, authored and reviewed test methods.
- Assistance in authoring SOPs to optimize test methods and procedures leading to a 20% reduction in analysis time.
- Maintaining accurate data entry in LIMS like Watson and ScieX Analyst for analyzing chromatographic data and pharmacokinetic data of clinical trial patients ensuring consistency with SOPs.
- Supporting equipment maintenance and calibration along with troubleshooting experience in MS and HPLC systems (Agilent, Shimadzu, Acquity).
- Conducted stability testing (freeze-thaw, benchtop) and drug-drug interference screening assays.
Master's Thesis
08.2023 - 04.2024
- Analysis of metformin biodistribution and tumor protein marker in head and neck cancer mouse xenograft models.
- LC-MS method development and validation for 97 pre-clinical samples, tissue and plasma processing.
- Generation of SOP, data indicated dose-response relationship, tumor protein analysis by western blot to study the expression of PDL-1 biomarker in response to metformin's anticancer effect.
Education
Master of Science - Pharmaceutical Science
Thomas Jefferson University
Philadelphia, PA04.2024
Bachelor of Pharmacy -
University of Mumbai, Dr Bhanuben Nanavati College of Pharmacy
Mumbai06.2022
Skills
- LC-MS
- HPLC
- SDS-PAGE
- Protein extraction
- Liquid-liquid extraction
- RNA Purification
- Western Blotting
- RT-PCR
- Assay Development
- Validation
- Tissue Homogenization
- Pharmacokinetic Analysis
- SOP generation
- HPLC-MS Troubleshooting
- Quality control
- GLP compliance
- Sample Processing
- CAPA Execution
- Deviation Investigations
- Preclinical mouse models
- Cancer biomarker biology
- Data interpretation
- Statistics
- Presentation
- Mammalian cell culture
- Cell Line Maintenance
- Cell Freezing
- Cell Thawing
- Media Prep
- Media Exchange
- Subculturing
- LIMS
- Watson
- Analyst for LC-MS data
- Prism
- UCSF Chimera
- SAS
- TRIOS
- Microsoft Office
- Scientific writing
- Laboratory management
Accomplishments
Active member of the Rho-Chi Pharmaceutical Honor Society.
Activities
- Active member of the Rho Chi Pharmaceutical Honor Society.
- International student orientation leader of Thomas Jefferson University.
Timeline
Analytical Scientist II
Syneos Health
07.2024 - Current
Master's Thesis
08.2023 - 04.2024
Master of Science - Pharmaceutical Science
Thomas Jefferson University
Bachelor of Pharmacy -
University of Mumbai, Dr Bhanuben Nanavati College of Pharmacy
Similar Profiles
Jessica Alejandra Mateos RodrÃguezJessica Alejandra Mateos RodrÃguez
Senior Clinical Research Associate at Syneos HealthSenior Clinical Research Associate at Syneos Health
Korissa PayneKorissa Payne
Engagement Center Medical Information Support Spec at Syneos HealthEngagement Center Medical Information Support Spec at Syneos Health
Jaime BirtJaime Birt
Associate Director Clinical Trial Management at Syneos HealthAssociate Director Clinical Trial Management at Syneos Health