Dominique Leboeuf
Montreal
Summary
Accomplished Senior Scientist with a proven track record at Beam Therapeutics, adept in leading pre-clinical pharmacology studies and managing teams. Knowledgeable in gene editing technologies and in vivo experiments, equipped with strong leadership and problem-solving abilities, willingness to learn, and excellent communication skills. Achieved significant contributions to IND and CTA applications, showcasing the ability to drive research forward and manage complex projects efficiently.
Overview
16
16
years of professional experience
Work History
Senior Scientist I
Beam Therapeutics
01.2023 - Current
- In vivo pharmacology team lead and dedicated manager of PhD and non-PhD scientists and associates
- Design, execute, and analyze pre-clinical pharmacology in vivo studies including efficacy, PK/PD and biodistribution studies in support of the CTA- and IND-approvals for in vivo gene-editing drug candidates, BEAM-301 (GSDIa) and BEAM-302 (A1AT), and IND-enabling studies for ESCAPE (SCD and beta-thalassemia) and HSC in vivo editing.
- Established best practices for laboratory techniques, enhancing efficiency and reproducibility of results.
- Lead scientific presentations to cross-functional teams, executive leadership, and external partnerships
- Manage transgenic mouse and rat colonies, assuring timely delivery of animals to pre-clinical and IND-enabling toxicology studies
- IACUC protocol development and ownership
- Scientist II 01/2022 to 01/2023
- Scientist I 10/2020 to 01/2022
Junior Research Scientist/PhD Student
Dr K Piatkov / Dr T Zatsepin's Labs, Skoltech
Moscow, Russia
09.2015 - 09.2020
- Performed research into UBR ubiquitin ligases and their role in apoptosis and inflammation in the context of liver cancer
- Collaborated with many scientists on several impactful publications
- Oversaw general lab management and training of Masters students
Procurement Consultant
Skoltech
Moscow, Russia
04.2014 - 09.2015
- Researched and evaluated vendors to determine suitability of products
- Worked with architects, researchers and lab personnel to design lab spaces and plan for proper equipment
- Built database of requests vs purchases for tracking purposes
Lab Manager/Research Assistant
Dr Martin Guimond's Laboratory, UofM
Montreal, Canada
04.2010 - 03.2014
- Oversaw and managed general lab work
- Trained master students and lab technicians
- Involved in all projects as well as led own research project
- Successfully managed budgets and resource allocation
Education
Ph.D. - Molecular Biology
Skoltech
Moscow, Russia09.2020
Master of Science - Biomedical Sciences
University of Montreal
Montreal, Canada06.2008
Bachelor of Science - Animal Physiology
University of Montreal
Montreal, Canada06.2006
Skills
- Design, planning and execution of in vivo pharmacology studies
- Animal colony management, animal handling, experimental and surgical techniques
- Training and mentorship of junior associates and scientists
- Knowledge of gene editing technologies as well as delivery methods
- Strong leadership skills, including communication, feedback delivery, motivation, and decision making
- Knowledge of advanced molecular biology methods, flow cytometry and histology
- Scientific writing
Languages
English
Native or Bilingual
French
Native or Bilingual
Timeline
Senior Scientist I
Beam Therapeutics
01.2023 - Current
Junior Research Scientist/PhD Student
Dr K Piatkov / Dr T Zatsepin's Labs, Skoltech
09.2015 - 09.2020
Procurement Consultant
Skoltech
04.2014 - 09.2015
Lab Manager/Research Assistant
Dr Martin Guimond's Laboratory, UofM
04.2010 - 03.2014
Master of Science - Biomedical Sciences
University of Montreal
Bachelor of Science - Animal Physiology
University of Montreal
Ph.D. - Molecular Biology
Skoltech
Publications
- Arnaoutova I, Aratyn-Schaus Y, Zhang L, Packer MS, Chen H-D, Lee C, Gautam S, Gregoire FM, Leboeuf D, Boule S, Fernandez TP, Huang V, Cheng L-l, Lung G, Bannister B, Decker J, Leete T, Shuang LS, Bock C, Kothiyal P, Grayson P, Mok KW, Quinn JJ, Young L, Barrera L, Ciaramella G, Mansfield B, Chou JY. Base-editing corrects metabolic abnormalities in a humanized mouse model for glycogen storage disease type-Ia. Nature Communications, 2024, 15,1,972
- Packer MS, Chowdhary V, Lung G, Cheng L-l, Aratyn-Schaus Y, Leboeuf D, Smith S, Shah A, Chen D, Zieger M. Evaluation of cytosine base editing and adenine base editing as a potential treatment for alpha-1 antitrypsin deficiency, Molecular Therapy, 2022, 30,4,1396-1406
- Smekalova E, Martinez MG, Combe E, Kumar A, Dejene S, Leboeuf D, Chen C-Y, Dorkin JD, Shuan Shuang L, Kieft S, Young L, Barrera L, Packer MS, Ciaramella G, Testoni B, Gregoire F, Zoulim F. Cytosine base editing inhibits Hepatitis B Virus replication and reduces HBsAg expression in vitro and in vivo, Molecular Therapy Nucleic Acids, 2024, 35,1
- Leboeuf, D., T. Abakumova, T. Prikazchikova, L. Rhym, D. G. Anderson, T. S. Zatsepin, and K. I. Piatkov. Downregulation of the Arg/N-degron Pathway Sensitizes Cancer Cells to Chemotherapy In Vivo. Mol Ther, 2020. 28: 1092-104.
- Gubina N, Leboeuf D, Piatkov K, and Pyatkov M. Novel Apoptotic Mediators Identified by Conservation of Vertebrate Caspase Targets. Biomolecules, 2020.10: 612.
- Gauthier SD, Leboeuf D, Gaboury L, Guimond M. SDF-1a and IL-7 treatment improve homeostatic proliferation of naïve CD4+ T cells after allogeneic stem cell transplantation, Biol Blood Marrow Transplant. 2015 Oct;21(10):1721-31
- Hennion-Tscheltzoff O, Leboeuf D, Gauthier SD, Dupuis M, Assouline B, Grégoire A, Thiant S and Guimond M. TCR triggering modulates the responsiveness and homeostatic proliferation of CD4+thymic emigrants to IL7 therapy. Blood. 2013 Jun 6;121(23):4684-93