Durga Manjari Arvapalli

Innovative and results-driven molecular genomics professional with extensive expertise in advanced molecular biology techniques, next-generation sequencing (NGS), and single-cell multi-omics, complemented by a strong foundation in nanoscience.

• Unifying genomics and transcriptomics in single cells with ResolveOME amplification chemistry to illuminate oncogenic and drug resistance mechanisms. Jon S. Zawistowski, Isai Salas-González, Tatiana V. Morozova, Jeff G. Blackinton, Tia Tate, Durga Arvapalli, Swetha Velivela, Gary L. Harton, Jeffrey R. Marks, E. Shelley Hwang, Victor J. Weigman, Jay A.A. West. bioRxiv 2022.04.29.489440; doi: https://doi.org/10.1101/2022.04.29.489440 (Preprint).
• Durga M. Arvapalli, Alex T. Sheardy, John J. Bang, and Jianjun Wei, Antiproliferative and ROS regulation activity of photoluminescent curcumin derived Nanodots. ACS Applied Bio Materials 2021 4 (12), 8477-8486.
• Allado, Kokougan & Liu, Mengxin & Jayapalan, Anitha & Arvapalli, Durga Manjari & Nowlin, Kyle. Binary MnO 2 /Co 3 O 4 Metal Oxides Wrapped on Superaligned Electropun Carbon Nanofibers as Binder Free Supercapacitor Electrodes. Energy & Fuels. 2021.
• Z. Yin, K. Allado, A. T. Sheardy, Z. Ji, D. Arvapalli, M. Liu, P. He, X. Zeng, J. Wei, Mingled MnO2 and Co3O4 binary nanostructures on well-aligned electropun carbon nanofibers for nonenzymatic glucose oxidation and sensing. Crystal Growth & Design, 2021.
• Arvapalli, D. M.; Sheardy, Alex.; Allado, Kokougan.; Cheva, Harish.; Wei, Jianjun, Design of Curcumin loaded Carbon Nanodots Delivery System: Enhanced Bioavailability, Release Kinetics and Anticancer Activity. ACS Applied Biomaterials 2020.
• Arvapalli, D. M.; Sheardy, A. T.; Alapati, K. C.; Wei, J., High Quantum Yield Fluorescent Carbon Nanodots for detection of Fe (III) Ions and Electrochemical Study of Quenching Mechanism. Talanta 2019.
• Ji, Z.; Arvapalli, D. M.; Zhang, W.; Yin, Z., Nitrogen and sulfur co-doped carbon nanodots in living EA. hy926 and A549 cells: oxidative stress effect and mitochondria targeting. Journal of Materials Science 2020.
• A. T. Sheardy, D. M. Arvapalli, J. Wei
• Novel microwave synthesis of near-metallic copper sulfide nanodiscs with size control: experimental and DFT studies of charge carrier density. Nanoscale Adv., 2020.
• Yin, Ziyu & Zeng, Xinping & Allado, Kokougan & Ji, Zuowei & Sheardy, Alex & Arvapalli, Durga Manjari. (2020). Binary MnO 2 /Co 3 O 4 @ Well-aligned Electropun Carbon Nanofibers for Sensitive, Nonenzymatic Glucose Sensing. ECS Meeting Abstracts, 2022.
• Experimental and Time-Dependent Density Functional Theory Modeling Studies on the Optical Properties of Carbon Nanodots. J. Phys. Chem. C 2020.
• Z. Zeng, W. Zhang, D. Arvapalli, B. Bloom, A. Sheardy, et al., A fluorescence-electrochemical study of carbon nanodots (CNDs) in bio-and photoelectronic applications and energy gap investigation. Physical Chemistry Chemical Physics. 19 (30), 20101-20109, 2017.
• Karshak Kosaraju, Durga Arvapalli, Kandas Womack, et al., Immobilized Growth Factor and Peptide on Indium Tin Oxide (ITO) Scaffold for Long-Term Hepatocyte culture towards Developing a Hepatotoxicity Bioreactor. International Conference on Systems in Medicine and Biology, 2016.
• Kumar, V.P., Prasanthi, S., Rohini, A., Sarada Gandhi, K., and Durga Manjari, A., Probiotics in Improving the Standards of Human Life. Developmental Microbiology and Molecular Biology, 2010. 1: p. 121-127.

• Durga M. Arvapalli, Isai Salas-González, Jon S. Zawistowski, Viren Amin, Victor J. Weigman, Gary L. Harton, Jay A.A. West. Integration of ResolveOME workflow with IDT xGenTM hybridization capture at single-cell resolution to obtain high quality exome data. AGRB, FL. 2023.
• Jon S. Zawistowski, Isai Salas-González, Tatiana V. Morozova, Katherine Kennedy, Durga M. Arvapalli, Swetha D. Velivela, Jamie E. Remington, Josh Croteau, Kevin Taylor, Jeff G. Blackinton, Victor J. Weigman, Jeffrey R. Marks, E. Shelley Hwang, Gary L. Harton, Jay A.A. West. Trimodal molecular analysis in single cells of a primary breast cancer cohort with ResolveOME amplification. AACR, LA. 2023.
• D.M. Arvapalli, I. Salas-Gonzalez, T.V. Morozova, Dan R. Goulet, G.L. Johnson, V.J. Weigman, J.A.A. West, G.L. Harton, J.S. Zawistowski. Co-delineating genomic and transcriptomic modes of resistance to MEK inhibition in individual triple negative breast cancer cells. ASHG, LA. 2022.
• Arvapalli DM, Salas-González I, Zawistowski JS, Blackinton JG, Hurt M, Harton GL, West JAA. Exploring microbial biodiversity through whole genome analysis using ResolveDNA Microbiome. Advances in Genomic Biology and Technology (AGBT) Annual Meeting, Orlando, FL. 2022.
• Kennedy KA, Zawistowski JS, Amin VR, Arvapalli DM, Salas-González I, Jäger N, Glimm H, Harton GL, Fröhling S, West JAA, Pfister S. Single-cell clarity and heterogeneity in copy number profiles in primary synovial and Ewing sarcoma with ResolveDNA genomic amplification. Advances in Genomic Biology and Technology (AGBT) Annual Meeting, Orlando, FL. 2022.
• Poster presentation on “Highly Fluorescent Carbon Nanodots (CNDs) for the Selective and Sensitive Detection of Iron (Fe (III)) ions” at ACS annual vendor night held at Syngenta, Greensboro, NC, 2019.
• Poster presentation on “High Quantum Yield Carbon Nanodots (CNDs) for Selective and Sensitive Detection of Iron (Fe (III)) ions & Bioimaging” at Nanomanufacturing Conference, Greensboro, NC, 2018.
• Poster presentation on “Carbon Nanodots (CNDs) Based Nanotheranotics for Treatment of Hepatocellular Carcinoma” at Nanomanufacturing Conference, Greensboro, NC, 2017.
• Poster presentation on “Immobilized Growth Factor Scaffolds for Long-Term Viability of Hepatocytes” at Wake Forest Institute of Regenerative Medicine, Winston Salem, NC. 2015.
• “Recent Advances in Computer aided Drug Design” a National Conference held in India, 2012.
• “Advances in Industrial Biotechnology” organized by OMICS Publishing Group’s World Congress on Biotechnology, March 2011.