Emily Nadeau

Dynamic postdoctoral research fellow with over six years of experience in molecular genetics and computational oncology, driving advancements in hereditary cancer research. Expertise in variant curation and interpretation, coupled with a strong background in functional genomics and cell culture. Proven ability to mentor students and collaborate across multidisciplinary teams to enhance research initiatives. Committed to leveraging knowledge gained through rigorous academic training and hands-on laboratory experience to contribute to innovative scientific discoveries in the field of genetics and oncology.

• Bergquist, T., Stenton, S.L., Nadeau, E.A.W., Byrne, A.B., Greenblatt, M.S., Harrison, S.M., Tavtigian, S.V., O’Donnell-Luria, A., Biesecker, L.G., Radivojac, P., Brenner, S.E., Pejaver, V., ClinGen Sequence Variant Interpretation Working Group. (2024). “Calibration of additional computational tools expands ClinGen recommendation options for variant classification with PP3/BP4 criteria.” Genetics in Medicine. 27(6):101402.
• Yin, X., Richardson, M.E., Laner, A., Shi, X., Ogneadal, E., Vasta, V., Hansen, T.v.O., Pineda, M., Ritter, D., den Dunnen, J.T., Hassanin, E., Lin, L., Wu, Borras, E., Krahn, K., Nordling, M., Martins, A., Mahmood, K., Nadeau, E.A.W., Beshay, V., Tops, C., Genuardi, M., Pesaran, T., Frayling, I.M., Capellá, G., Latchford, A., Tavtigian, S.V., Maj, C., Plon, S.E., Greenblatt, M.S., Macrae, F.A., Spier, I., and Aretz, S. (2024). “Large-scale application of ClinGen-InSiGHT APC-specific ACMG/AMP variant classification criteria leads to substantial reduction in VUS.” American Journal of Human Genetics. 111(1):P2427–2443.
• Stenton, S.L., Pejaver, V., Bergquist, T., Biesecker, L.G., Byrne, A.B., Nadeau, E.A.W., Greenblatt, M.S., Harrison, S., Tavtigian, S., Radivojac, P., O’Donnell-Luria, A., ClinGen Sequence Variant Interpretation Working Group. (2024). “Assessment of the evidence yield for the calibrated PP3/BP4 computational recommendations.” Genetics in Medicine. 26(11):102113.
• Thet, M., Plazzer, J.P., Capella, G., Latchford, A., Nadeau, E.A.W., Greenblatt, M.S., and Macrae, F. (2024). “Phenotype Correlations with Pathogenic DNA Variants in the MUTYH Gene: A Review of Over 2000 Cases.” Human Mutation. 2024:1–10.
• Nadeau, E.A.W., Lecheta, M.C., Obrycki, J.J., and Teets, N.M. (2022). “Transcriptional Regulation of Reproductive Diapause in the Convergent Lady Beetle Hippodamia convergens.” Insects. 13(4):343.
• Zhou, S.*, Nadeau, E.A.W.*, Khan, A., Webb, B.A., Rankin, S.E., and Knutson, B.L. (2021). “Relating Mobility of dsRNA in Nanoporous Silica Particles to Loading and Release Behavior.” ACS Applied Bio Materials. 4:8267–8276. (* = co-first authors)
• Khan, M.A., Kiser, M., Moradipour, M., Nadeau, E.A.W., Ghanim, R., Webb, B., Rankin, S. and Knutson, B. (2020). “Effect of Confinement in Nanopores on RNA Interactions with Functionalized Mesoporous Silica Nanoparticles.” Journal of Physical Chemistry B. 124(39):8549–8561.
• Nadeau, E.A.W. and Teets, N.M. (2020). “Evidence for a Rapid Cold–Hardening Response in Cultured Drosophila S2 Cells.” Journal of Experimental Biology. 223(2):jeb212613.