Eser Akturk
Horsham,PA
Summary
Accomplished Senior Scientist at GSK Glaxo Smith Kline, proficient in High Performance Liquid Chromatography (HPLC) and skilled in analytical problem-solving. Demonstrated expertise in developing innovative methodologies, leading projects, and authoring essential documentations as an Analytical Lead.
Overview
16
16
years of professional experience
Work History
Senior Scientist
GSK Glaxo Smith Kline
01.2023 - Current
- cGMP experience working with pharmaceutical API and drug products.
- Currently leading a high value project as an Analytical Lead with strict deadlines, prioritizing tasks effectively to maintain progress without sacrificing quality or accuracy.
- Authored several cGMP documents to support IND submissions and amendments, setting product shelf-life, method validations, and certificates of analysis.
- Developed and validated assay, assay of related compounds, and dissolution methods.
- Experience using Empower3 software with HPLC, UPLC, GC-FID, and GC-Headspace instruments.
- Collaborated with the GSK automation group to implement automated sample preparations within the analytical department using automation equipment such as SPT Labtech's DRAGONFLY.
- Championed data collection and management using visual data programs such as Spotfire.
- Performed complex troubleshooting and assisted in leading initiatives to solve challenging scientific problems with assays or instrumentation.
- Participated in strategic planning efforts with Formulators to support ongoing drug product development.
Analytical Scientist II
Lannett INC
05.2021 - 12.2022
- Analyzed stability samples at several time points at both ICH long-term, accelerated, and stressed conditions.
- Performed assay, assay of related compounds, dissolution, residual solvents, blend and content uniformity, dissolution, and several USP monographs to support release and stability testing.
- Worked with a variety of API and drug products that were classified as controlled Class II or high potent.
- Led a project supporting formulations research.
- Previously employed with Frontida Biopharm, as an Analytical Scientist from 04/2020 to 04/2021.
Senior Materials Scientist
EMSL Analytical
08.2017 - 04.2020
- Developed new testing methodology involving GC-MS, HPLC, BET (Brunauer, Emmett, and Teller) Surface area,TOC (Total Organic Carbon) and melt-flow index.
- Performed analysis based on ASTM, USP, Standard Methods, EPA, and FDA methods and guidelines.
- Analyzed and submitted TOC Proficiency Testing results for continued A2LA accreditation.
- Identified unknown materials and compounds using a wide variety of analytical techniques.
- Maintained and repaired instruments including GC-MS, HPLC, TOC analyzer, NMR, and BET.
Post-Doctoral Studies
University of Colorado at Boulder
04.2016 - 03.2017
- Worked as a post-doctoral RASEI research associate at the University of Colorado Boulder.
- Synthesized several bulky Acetyl Acetone (AcAc) ligands via high-scale, multi-step organic synthesis.
- Prepared several AcAc transition metals complexes featuring first row transition metals such as Ti, V, Cr, Mn, Fe, Co, Cu, and Zn.
- Characterized novel organic compounds and transition metal complexes using NMR and FT-IR spectroscopy and X-Ray Crystallography.
- Highly skilled in handling air sensitive materials using inert atmosphere glove boxes, high vacuum lines, and Schlenk techniques.
- Experienced in the use and proper disposal of corrosive, pyrophoric, highly reactive, and carcinogenic chemicals.
- Mentored several graduate and undergraduate students in basic laboratory techniques and experimental design.
Ph.D. Studies
University Of Delaware
09.2009 - 02.2016
- Completed a Ph.D. in Chemistry.
- Prepared several bulky Trispyrazolylborate (Tp) and Beta-diketiminate (NacNac) ligands.
- Synthesized rare and highly reactive Chromium (I) Dinitrogen complexes to activate various small molecules for catalysis.
- Explored the mechanism of dioxygen activation by low valent chromium complexes by synthesizing possible reactive intermediates.
Education
Bachelor of Science - Chemistry
New York University
New York, NY05.2009
Ph.D. - Chemistry
University of Delaware
Newark, DE05-2009
Skills
- High Performance Liquid Chromatography (HPLC)
- Ultra Performance Liquid Chromatography (UPLC)
- Gas Chromatography (GC-MS, GC-FID)
- Ultraviolet-Visible Spectroscopy (UV-Vis)
- Infrared Spectroscopy (IR)
- Water Content by Karl Fischer Titration (KF)
- Potentiometric Titration
- Dissolution Apparatus I and II
- Nuclear Magnetic Resonance (NMR)
- Particle Size Analysis
- Inductively Coupled Plasma Mass Spectrometry (ICP-MS)
Timeline
Senior Scientist
GSK Glaxo Smith Kline
01.2023 - Current
Analytical Scientist II
Lannett INC
05.2021 - 12.2022
Senior Materials Scientist
EMSL Analytical
08.2017 - 04.2020
Post-Doctoral Studies
University of Colorado at Boulder
04.2016 - 03.2017
Ph.D. Studies
University Of Delaware
09.2009 - 02.2016
Bachelor of Science - Chemistry
New York University
Ph.D. - Chemistry
University of Delaware
Publications
- Krajewski, S. M.; Crossman, A. S.; Akturk, E. S.; Suhrbier, T.; Scappaticci, S. J.; Stabb, M. W.; Marshak, M. P.; "Sterically encumbered Beta-dikeonates and base metal catalysis", Dalton Trans., 2019, 48, 10714-10772. (DOI: 10.1039/C9DT02293G)
- Crossman, A. S.; Larson, A. T.; Shi, J. X.; Krajewski, S. M.; Akturk, E. S.; Marshak, M. P.; "Synthesis of Sterically Hindered Beta Diketones via Condensation of Acid Chlorides with enolates", J. Org. Chem., 2019, 84, 11, 7434-7442. (DOI: 10.102I/acs.joc.9b00433)
- Akturk, E. S.; Scappaticci, S. J.; Seals, R. N.; Marshak, M. P.; "Bulky Beta-diketones enabling new Lewis acidic ligand platforms", Inorg. Chem., 2017, 56, 19, 11466-11469. (DOI: 10.1021/acs.inorgchem.7b02077)
- Akturk, E. S.; Yap, G. P. A.; Theopold, K. H.; "O2 Activation by Non-adiabatic Oxidative Addition to a Single Metal Center", Angew. Chem. Int. Ed., 2015, 54, 14974-14977. (DOI: 10.1002/anie.201508777)
- Akturk, E. S.; Yap, G. P. A.; Theopold, K. H.; "Mechanism-Based Design of Labile Precursors for Chromium (I) Chemistry", Chem. Commun., 2015, 51, 15402-15405. (DOI: 10.1039/c5cc05993c)
- Sirianni, E. R.; Yap, G. P. A.; Akturk, E. S.; Theopold, K. H.; "Improved syntheses, and structural and electronic characterization of carboxamide-substituted TpCONHPH,Me and TPCONHt-bu,Me Ligands", Acta Crystallographica, Section C: Crystal Structure Communications, 2013, 69(9), 947-953. (DOI: 10.1107/S010827011315898)