Summary
Overview
Work History
Education
Skills
Awards
Publications
Selected Presentations
Websites
Timeline
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Esther Holt

Belton,MO

Summary

Motivated professional eager to embrace new challenges. Demonstrates strong work ethic, adaptability, and exceptional interpersonal skills. Proven ability to work independently and quickly develop new skills.

Overview

7
7
years of professional experience

Work History

Menopausal Effects on Multiple Sclerosis

Dr. Meredith Hartley
University of Kansas
01.2022 - 01.2025
  • Investigated menopausal effects on multiple sclerosis via generation of menopausal mouse model of demyelination utilizing surgical and inducible conditional knockout techniques alongside behavioral, imaging, and lipidomic experiments.
  • Executed studies on lysophosphatidic acid effects on multiple sclerosis through design, synthesis, and characterization of forester resonance energy transfer lysophosphatidylcholine probes for real-time monitoring of lysophosphatidic acid generation by autotaxin.

Graduate Teaching Assistant

University of Kansas
01.2019 - 01.2023

In the Field of Chemistry- General Chemistry Lab, Organic Chemistry Lab, Analytical Chemistry Lab.

  • Organized lectures, seminars, workshops, and other activities related to the subject matter of the class.
  • Facilitated discussions among students during class sessions.
  • Maintained accurate records of student attendance and grades in accordance with university policies.
  • Conducted weekly office hours to provide academic guidance to students.

Phytate Conformational Flipping

Dr. Kristin Bowman-James
University of Kansas
01.2020 - 01.2022
  • Analyzed effects of various biologically relevant metal cations, nonmetal bases, and macrocycles on conformational flip of inositol hexaphosphates using nuclear magnetic resonance spectroscopy titrations, pH studies, and crystallography.

Vinyl Sulfone Derivative Synthesis

Dr. Paul Hanson
University of Kansas
01.2019 - 01.2020
  • Conducted synthesis, purification, and characterization of 6-membered vinyl sulfone derivatives for cysteine inhibition.

Phidianidine Analog Synthesis

Dr. Bryan Wakefield
University of Kansas
01.2018 - 01.2019
  • Conducted synthesis, purification, and characterization of phidianidine analogs for application as pain-reducing agents and protective properties against Alzheimer’s disease.

Education

Ph.D. - Chemistry

University of Kansas
Lawrence, KS
07.2025

Bachelor of Science - Biochemistry

Coastal Carolina University
Conway, SC
01.2019

Skills

  • Variety of animal work
  • Imaging
  • Immunofluorescent staining
  • Lipidomic extractions
  • Mass spectrometry
  • 2D/3D NMR
  • General synthesis
  • Word
  • MestreNova
  • Fiji
  • Prism
  • BioRender
  • WINEQNMR2
  • Time and project management
  • Team leadership
  • Project oversight
  • Analytical and critical thinking
  • Research methodology
  • Scientific writing
  • Multitasking
  • Variety of lab equipment operations
  • PPE use
  • Procedure creation
  • MS office

Awards

  • KU Departmental Award, 2024
  • Graduate Certificate in Chemical Biology, 2023
  • NIH Chemical Biology Traineeship, 01/2021, 12/2023
  • Best Chemistry/Biochemistry poster, SC INBRE Science Symposium, 2018

Publications

  • Holt, E.; Kobayashi, H.; Fairchild, C.; Jones, R.; Garcia, A.; Ramirez, J.; Zupan, M.; Hartley, M.; “Estrogen Depletion Effects on Lipid Homeostasis and Myelination” (Publication in Preparation, Expected 2026)
  • Holt, E., “Estrogen Depletion and Lysophosphatidyl Choline Effects on Myelination and Lipid Regulation within the Central Nervous System” (Ph.D. Thesis, 2025)

Selected Presentations

  • Holt, E.; Kobayashi, H.; Fairchild, C.; Jones, R.; Garcia, A.; Ramirez, J.; Zupan, M.; Hartley, M.; “Estrogen Depletion Effects on Lipid Homeostasis and Myelination” Pittcon 2025 Conference and ExpositionBoston, MA, March 2025. (Oral and Poster Presentation)
  • Holt, E.; Kobayashi, H.; Fairchild, C.; Jones, R.; Garcia, A.; Hartley, M.; “Estrogen Depletion Effects on Lipid Homeostasis and Myelination” Myelin Gordon Research Conference, Ventura, CA, March 2024. (Poster Presentation)
  • Holt, E.; Dhokale, R.; Hartley, M.; “Real-time Imaging of Autotaxin within Oligodendrocyte Precursor Cells” COBRE Center for Molecular Analysis of Disease Pathways 10th Anniversary Symposium, Kansas City, KS, May 2023. (Poster Presentation)
  • Holt, E.; Pramanik, S.; Bowman-James, K.; “Tricyclic hosts and the influence of water for simple and complex anion binding” American Chemical Society Spring 2021, Virtual, April 2021. (Poster Presentation)

Timeline

Menopausal Effects on Multiple Sclerosis

Dr. Meredith Hartley
01.2022 - 01.2025

Phytate Conformational Flipping

Dr. Kristin Bowman-James
01.2020 - 01.2022

Graduate Teaching Assistant

University of Kansas
01.2019 - 01.2023

Vinyl Sulfone Derivative Synthesis

Dr. Paul Hanson
01.2019 - 01.2020

Phidianidine Analog Synthesis

Dr. Bryan Wakefield
01.2018 - 01.2019

Ph.D. - Chemistry

University of Kansas

Bachelor of Science - Biochemistry

Coastal Carolina University