Fang Liu

• A diligent, seasoned scientist with expertise in epigenetic, cancer biology, and neurobiology.
• Intensive hands-on experience in both traditional and modern research methodologies.
• Outstanding research skills combined with effective decision-making talents.
• Detail-oriented scientist with first-rate active listening, communication and planning traits.
• Well-trained in study design and implementation, and successfully led many projects.

• Addressed critical questions about pulmonary carcinogenesis and published the data in Oncogene with 298 citations (https://pubmed.ncbi.nlm.nih.gov/20440268/)
• Revealed elegant biological processes of cerebellar development and published the data in Nature Neuroscience, etc.
• Contributed to research studies published in many high-impact journals such as Science, Nature Neuroscience, Nature Methods, JBC, PNAS, and Blood.

1. A Subset of Cerebellar Granule Neuron Genes Are Regulated by Polycomb Group Proteins, Fang Liu, Melyssa Minto, Anne E. West, Neurobiology Retreat, September 26 - September 28, 2018, Durham, North Carolina.

2. Regulation of chromatin accessibility and Zic binding at enhancers in the developing cerebellum, Frank CL, Liu Fang, Wijayatunge R, Song L, Biegler MT, Yang MG, Gersbach CA, Crawford GE, West AE, Neurobiology Retreat, September 30 to October 2, 2015, Wrightsville, North Carolina.

3. Instructive Mechanism of De Novo DNA Methylation and Gene Silencing during Tobacco- Induced Pulmonary Carcinogenesis, Fang Liu1, J. Keith Killian, Robert L. Walker, Julie A. Hong, Paul A. Meltzer, David S. Schrump. Environmental Epigenomics and Disease Susceptibility (D3) March 27 - April 1, 2011, Asheville, North Carolina.

4. Knockdown of EZH2 inhibits the malignant phenotype of Lung Cancer Cells Fang Liu, Clinton Kemp, David Schrump. AACR 101st Annual Meeting April 17-21, 2010, Washington D.C.

5. Oral presentation: Epigenomic alterations and gene expression profiles in respiratory epithelia exposed to cigarette smoke condensate. Fang Liu, Keith J. Killian, Maocheng Yang, Paul A. Meltzer, David Schrump AACR Cancer Epigenetics Meeting, January 20-23, 2010, San Juan, Puerto Rico.

6. Oral presentation: Sequential Alterations and Gene Expression Profiles Coincide with Malignant Transformation in Respiratory Epithelia Exposed to Cigarette Smoke Fang Liu, Keith J. Killian, Maocheng Yang, Paul A. Meltzer, David Schrump. Ninth Annual Fellows & Young Investigators Colloquium. March 18- 20, 2009, Hershey, Pennsylvania

7. Structure and Function of novel isoforms of PTEN involved in several human cancers. Fang Liu, Y. Fujimura, E. Reddy. Drexel and MCP Hahnemann University Research Day 05/2001, Philadelphia, Pennsylvania

8. EWS-ATF-1 chimeric protein in soft tissue clear cell sarcoma associates with CREB-binding protein and interferes with P53-mediated trans-activation function. Yasuo Fujimura, Fang Liu, E. Reddy. Drexel and MCP Hahnemann University Research Day 05/2002, Philadelphia, Pennsylvania

1. Liu, Fang, Minto, M. Chan, U. and West A.E. KDM6B-Mediated H3K27Me3 Dynamics Orchestrate postnatal development of cerebellum. Target journal: Genome Research or Genes and Development. In preparation.
2. David A. Gallegos, Melyssa Minto, Fang Liu, Mariah F. Hazlett, S. Aryana Yousefzadeh, Luke C. Bartelt, Anne E. West. Cell-type specific transcriptional adaptations of nucleus accumbens interneurons to amphetamine. Mol Psychiatry (2022). https://doi.org/10.1038/s41380-022-01466-1.
3. Matthew P. Gemberling, Keith Siklenka, Erica Rodriguez, Katherine R. Tonn-Eisinger, Alejandro Barrera, Fang Liu, Ariel Kantor, Liqing Li, Valentina Cigliola, Mariah F. Hazlett, Courtney A. Williams, Luke C. Bartelt, Victoria J. Madigan, Josephine C. Bodle, Heather Daniels, Douglas C. Rouse, Isaac B. Hilton, Aravind Asokan, Maria Ciofani, Kenneth D. Poss, Timothy E. Reddy, Anne E. West & Charles A. Gersbach Transgenic mice for in vivo epigenome editing with CRISPR-based systems. Nature Methods 02 August 2021
4. Whasil Lee, Robert J. Nims, Alireza Savadipour, Qiaojuan Zhang, Holly A. Leddy, Fang Liu, Amy L. McNulty, Yong Chen, Farshid Guilak, Wolfgang B. Liedtke Inflammatory signaling sensitizes Piezo1 mechanotransduction in articular chondrocytes as a pathogenic feed-forward mechanism in osteoarthritis Proc Natl Acad Sci U S A. 2021 Mar 30; 118(13): e2001611118. Published online 2021 Mar 23. doi: 10.1073/pnas.2001611118
5. Liang-Fu Chen, Michelle R Lyons, Fang Liu, Matthew V Green, Nathan G Hedrick, Ashley B Williams, Arthy Narayanan, Ryohei Yasuda, Anne E West. The NMDA receptor subunit GluN3A regulates synaptic activity-induced and myocyte enhancer factor 2C (MEF2C)-dependent transcription. J Biol Chem. 2020 Jun.
6. Wijayatunge R*, Liu Fang*, Shpargel KB, Wayne NJ, Chan U, Boua JV, Magnuson T, West AE. The histone demethylase Kdm6b regulates a mature gene expression program in differentiating cerebellar granule neurons Mol Cell Neurosci. 2018 Mar *coauthor
7. Frank CL, Liu Fang, Wijayatunge R, Song L, Biegler MT, Yang MG, Vockley CM, Safi A, Gersbach CA, Crawford GE, West AE. Regulation of chromatin accessibility and Zic binding at enhancers in the developing cerebellum. Nat Neurosci. 2015 May
8. Whitney O, Pfenning AR, Howard JT, Blatti CA, Liu Fang, Ward JM, Wang R, Audet JN, Kellis M, Mukherjee S, Sinha S, Hartemink AJ, West AE, Jarvis ED. Core and region-enriched networks of behaviorally regulated genes and the singing genome. Science. 2014 Dec
9. Yao X, Ahmadzadeh M, Lu YC, Liewehr DJ, Dudley ME, Liu Fang, Schrump DS, Steinberg SM, Rosenberg SA, Robbins PF. Levels of peripheral CD4+FoxP3+ regulatory T cells are negatively associated with clinical response to adoptive immunotherapy of human cancer. Blood. 2012 May 3.
10. Mahadev Rao, Nachimuthu Chinnasamy, Julie A. Hong, Yuwei Zhang, Mary Zhang, Sichuan Xi, Fang Liu, Victor E. Marquez, Richard A. Morgan, David S. Schrump. Inhibition of Histone Lysine Methylation Enhances Expression of Cancer-Testis Genes in Lung Cancer Cells: Implications for Adoptive Immunotherapy of Cancer. Cancer Res. 2011 May 5
11. Fang Liu, JK Killian, M Yang, RL Walker, JA Hong, M Zhang, PA Meltzer and DS Schrump. Epigenomic alterations and gene expression profiles in respiratory epithelia exposed to cigarette smoke condensate. Oncogene. 2010 May 3
12. Fang Liu, Pore N, Kim M, Voong KR, Dowling M, Maity A, Kao GD. Regulation of Histone Deacetylase 4 Expression by SP Family Transcription Factors. Mol Biol Cell. 2006. Feb 17; 17(2):585-97.
13. Fang Liu, Dowling M, Yang XJ, Kao GD. Caspase-mediated Specific Cleavage of Human Histone Deacetylase 4. J Biol Chem. 2004 Aug 13; 279(33):34537-46.
14. Yang S, Liu F, Wang QJ, Rosenberg SA, Morgan RA. The shedding of CD62L (L-selectin) regulates the acquisition of lytic activity in human tumor reactive T lymphocytes. PLoS One. 2011;6(7): e22560. Epub 2011 Jul 28.
15. Shicheng Yang, Gattinoni Luca, Fang Liu, Yun Ji, Zhiya Yu, Nicholas P. Restifo, Steven A. Rosenberg, Richard A. Morgan. In vitro generated anti-tumor T lymphocytes exhibit distinct subsets mimicking in vivo antigen-experienced cells. Cancer Immunol Immunother (2011) 60:739–749
16. Mustafa Hussain, Mahadev Rao, Ashley E. Humphries, Julie A. Hong, Fang Liu, Maocheng Yang, Diana Caragacianu and David S. Schrump. Tobacco Smoke Induces Polycomb-Mediated Repression of Dickkopf-1 in Lung Cancer Cells. Cancer Res 2009;69(8):3570–8
17. Kim M, Murphy K, Liu Fang, Parker SE, Dowling M, Baff W, Kao GD. Caspase-mediated specific cleavage of BubR1 is a determinant of mitotic progression. Mol Cell Biol. 2005 Nov; 25(21):9232-48.
18. Ramakrishnan R, Fujimura Y, Zou JP, Liu Fang, Lee L, Rao VN, Reddy ES. Role of protein-protein interactions in the antiapoptotic function of EWS-Fli-1. Oncogene. 2004 Jul 26
19. Liu Fang et.al Analysis of variation of EBVLMP1 gene in a transplantable nude mouse NPC tumor cell strain (SUNT) and its corresponding cell lines (SUNE). Journal of JiNan University.1998;19(2)
20. Liu Fang, Yang Shicheng, et al. The Variation of IL-2, IL-4 by CD3+ T cells from PBMC of NPC patients. Chinese Journal of Immunology. 1997;13:19
21. Zuo LiMei, Liu F et al. Rapid detection of Mycobacterium Tuberculosis DNA from clinical specimen by PCR. New trend of Microbiology and Immunology.1995;23(1):17-21
22. Liu Fang, et al. The reversion of T lymphocyte signal transduction in tumor immunity (review). Foreign Medicine Neoplasm. 1996; 6: 301
23. Liu Fang, et al. The progressing of CD23 expression and B cells proliferation (review). Foreign Medicine Immunology. 1997; 20: 150.