Fei Ye
Boston,MA
Summary
Dedicated Life Scientist with experience in laboratory research. Expertise in medicinal chemistry and background in natural product chemistry and chemical biology. Proficient in advanced chemistry and microbiology laboratory equipment use and techniques.
Overview
4
4
years of professional experience
Work History
Research Fellow
Harvard Medical School
01.2022 - Current
- Used strategies from chemical biology to study human microbiome and discover new drugs.
- Collaborated with surgeons from BWH to identify beneficial factors post bariatric surgery.
- Edited papers for submission to prestigious academic and industry journals.
- Peer reviewed over 40 manuscripts from pretigious18 journals.
Postdoctoral Research Associate
The Scripps Research Institute
10.2018 - 12.2021
- Collaborated with synthetic biologists and chemical biologists to accomplish the bioengineering for enediyne family natural products, biosynthetic studies for ammosester compounds and the anticancer properties evaluations.
- Lead the microRNA binders screening campaign and collaborated with RNA biologists to test the bioactivity of the hits.
- Formatted the natural products library to enable the high throughput screening.
- Fermented the producers for bioactive natural products and purified the target compounds.
- Maintained various chemistry and microbiology instrumentation including GC-MS, HPLC, MPLC, LC-MS/MS and fermentation shakers, etc.
- Trained the graduates with natural products isolation/purification and structure elucidation skills.
Education
Ph.D - Medicinal Chemistry
Shanghai Institute of Materia Medica, Chinese Academy of Sciences
06.2018
B.S - Pharmacy
Shandong University
06.2013
Skills
- Natural Products Isolation and Structure Elucidation
- Targeted- and Untargeted- Metabolomics
- Separation, Culture and Fermentation for microbes
- High Throughput Screening for Bioactive Compounds
- Analytical Chemistry and Computational Chemistry
Additional Information
- Ye, F. #; Haniff H. S. #; Suresh, B. M. #; Yang, D.; Zhang, P.; Crynen, G.; Teijaro, C. T.; Yan, W.; Abegg, D.; Adibekian, A.; Shen, B.; Disney, M. D., Rational approach to identify RNA targets of natural products enables identification of nocathiacin as an inhibitor of an oncogenic RNA. ACS Chem. Biol., 2022, 17 (2), 474-482. ( # Co-first author)
- Yang, D. #; Ye, F. #; Teijaro, C. T.; Hwang D.; Annaval, T.; Adhikari, A.; Li, G.-N.; Yan, X.-H., Gui, C.; Rader, C.; Shen, B., Functional characterization of cytochrome P450 hydroxylase YpmL in yangpumicin A biosynthesis and its application for structural diversification. Org. Lett., 2022, 24 (5), 1219-1223. ( # Co-first author)
- Ye, F.; Zhu, Z.-D.; Chen, J.-S.; Li, J.; Gu, Y.-C.; Zhu, W.-L.; Li, X.-W.; Guo, Y.-W., Xishacorenes A–C, diterpenes with bicyclo [3.3. 1] nonane nucleus from the Xisha soft coral Sinularia polydactyla. Org. Lett., 2017, 19 (16), 4183-4186. JCRQ1
Awards and Honors
• Syngenta Fellowship Award
• Special Award (First Prize) in the First National Marine Life Sciences Forum
• Dior PhD Fellowship
• “Three Good” student (good in study, attitude and health) of CAS
Languages
English
Full Professional
Chinese (Mandarin)
Native or Bilingual
Timeline
Research Fellow
Harvard Medical School
01.2022 - Current
Postdoctoral Research Associate
The Scripps Research Institute
10.2018 - 12.2021
Ph.D - Medicinal Chemistry
Shanghai Institute of Materia Medica, Chinese Academy of Sciences
B.S - Pharmacy
Shandong University
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