An academic scientist with nearly 10 years of experience in biomedical research, specializing in hematology. I am seeking teaching positions to share my scientific expertise and passion with biomedical students. I am highly enthusiastic about mentoring and inspiring the next generation of scientists. My goal is to contribute to advancing scientific knowledge and education through dedicated teaching and innovative research.
Laboratory Student Demonstrator | 2015 to 2018
University of Reading - Reading, UK
Supported undergraduate students with their laboratory practicals, focusing specifically on blood sciences.
Mentor for Undergraduate Students | 2017 to 2017
University of Reading - Reading, UK
Supervised undergraduate dissertation projects spanning six months. Guiding them with project objectives, experiments, and dissertation writing.
Mentor | 07/2015 to 07/2017
Heart Health (University of Reading and Future Learn Group) - Reading, UK
Responsible for disseminating information and addressing inquiries about cardiovascular health on a global platform, guiding the audience through modules, and answering their questions.
American Heart Association (AHA) Postdoctoral grant ($140,952): 2022 – 24
Project: Role of Pyruvate Dehydrogenase Kinases in regulating platelet function and thrombosis
Principal Investigator: Gagan Flora
University of Iowa Pilot Hematology Grant ($25,000): 2024 – 25
Project: Role of Pyruvate Dehydrogenase Kinases in Regulating Neutrophil Activation and DVT
Principal Investigator: Gagan Flora
ORAL PRESENTATIONS
1. Vascular Discovery: From Genes to Medicine, Chicago, US, 2024
Flora GD, Nayak MK, Ghatge M, Barbhuyan T, Chauhan AK. Deletion of pyruvate dehydrogenase kinases reduces susceptibility to experimental venous thrombosis by limiting glycolysis in neutrophils
2. Gordon Research Seminar (GRS), Waterville Valley, New Hampshire, US, 2022.
Flora GD, Nayak MK, Ghatge M, Kumskova M, Patel RB, Chauhan AK. Pyruvate dehydrogenase kinases potentiate platelet function and thrombosis in mice by modulating metabolic plasticity.
3. UK Platelet Meeting, University of Leicester, UK, 2015.
Flora GD, Unsworth AJ, Bye A, Sahli KA, Kriek N, Holbrook LM, Crescente M, Sage T, Schenk M, Stainer AR, Gibbins JM. Retinoid x receptor ligands exhibit non-genomic effects to inhibit collagen and thrombin-mediated platelet activation. Platelets. 2016;27(1):2-25
POSTER PRESENTATIONS
1. Thrombosis & Hemostasis Summit of North America (THSNA), Chicago, USA, 2022
2. University of Iowa Annual Internal Medicine Research Day, Iowa City, USA, 2021.
3. The International Society on Thrombosis and Haemostasis (ISTH), Berlin, 2017.
4. International Gap Junction Conference, Glasgow, UK, 2017.
5. UK Platelet Meeting, University of Bath, UK, 2017.
6. European Platelet Network Meeting, Homburg (Germany), 2016.
7. Joint BSHT, AiP & UK Platelet Group Meeting, Leeds, UK, 2016.
MY BIBLIOGRAPHY
https://www.ncbi.nlm.nih.gov/myncbi/gagan.flora.2/bibliography/public/
https://scholar.google.com/citations?user=XCF12x4AAAAJ&hl=en
Citations: 3,777 h-index: 16
1. Flora GD*, Ghatge M, Nayak MK, Barbhuyan T, Kumskova M, Chauhan AK*. Deletion of pyruvate dehydrogenase kinases reduces susceptibility to deep vein thrombosis in mice. Blood Adv. (Accepted: in press).
(*Co-Corresponding Authors)
2. Flora GD, Nayak MK, Ghatge M, Kumskova M, Patel RB, Chauhan AK. Mitochondrial pyruvate dehydrogenase kinases contribute to platelet function and thrombosis in mice by regulating aerobic glycolysis. Blood Adv, 2023; 7(11), 2347-59. (PMID: 36971790)
3. Flora GD*, Nayak MK, Ghatge M, Chauhan AK*. Metabolic Targeting of Platelets to Combat Thrombosis: Dawn of a New Paradigm? Cardiovasc Res. 2023;119(15):2497-2507. (PMID: 37706546)
(*Co-Corresponding Authors)
4. Ghatge M, Flora GD,Nayak MK, Chauhan AK. Platelet Metabolic Profiling reveals Glycolytic and 1-Carbon Metabolites are Essential for GPVI-stimulated human platelets. Arterioscler Thromb Vasc Biol, 2023 (PMID: 37942614)
5. Kumskova M, Flora GD, Staber J, Lentz SR, Chauhan AK. Characterization of bleeding symptoms in Ehlers-Danlos syndrome. J Thromb Haemost, 2023; 21(7): 1824-30. (PMID: 37179130)
6. Ghatge M, Nayak MK, Flora GD, Kumskova M, Jain A, Patel RB, Lin Z, Usachev Y, Chauhan AK. Mitochondrial calcium uniporter b deletion inhibits platelet function and reduces susceptibility to arterial thrombosis. J Thromb Haemost, 2023; 21(8):2163-2174 (PMID: 37061131)
7. Nayak MK, Flora GD, Chauhan AK. Constitutively active ADAMTS13: An emerging thrombolytic agent for acute ischemic stroke. J Thromb Haemost, 2022; 20(4):790-93. (PMID: 35106938)
8. Dhanesha N, Patel RB, Doddapattar P, Ghatge M, Flora GD, Jain M, Thedens D, Olalde H, Kumskova M, Leira EC, Chauhan AK. PKM2 promotes neutrophil activation and cerebral thromboinflammation: therapeutic implications for ischemic stroke. Blood, 2022;139(8):1234-45. (PMID: 34529778)
9. Sahli KA*, Flora GD*, Sasikumar P, Maghrabi AH, Holbrook LM, AlOuda SK, Elgheznawy A, Sage T, Stainer AR, Adiyaman R, AboHassan M. Structural, functional, and mechanistic insights uncover the fundamental role of orphan connexin-62 in platelets. Blood, 2021;137(6):830-43. (PMID: 32822477)
(*Co-First Authors)
10. Nayak MK, Ghatge M, Flora GD, Dhanesha N, Jain M, Markan KR, Potthoff MJ, Lentz SR, Chauhan AK. The metabolic enzyme pyruvate kinase M2 regulates platelet function and arterial thrombosis. Blood, 2021;137(12):1658-68. (PMID: 33027814)
11. Dhanesha N, Nayak MK, Doddapattar P, Jain M, Flora GD, Kon S, Chauhan AK. Targeting myeloid-cell specific integrin α9β1 inhibits arterial thrombosis in mice. Blood, 2020; 135(11):857-61. (PMID: 31951649)
12. Flora GD, Sahli KA, Sasikumar P, Holbrook LM, Stainer AR, AlOuda SK, Crescente M, Sage T, Unsworth AJ, Gibbins JM. Non-genomic effects of the Pregnane X Receptor negatively regulate platelet functions, thrombosis and hemostasis. Sci Rep, 2019; 9(1):1-4. (PMID: 31748641)
13. Flora GD, Nayak MK. A brief review of cardiovascular diseases associated risk factors and current treatment regimes. Curr Pharm Design, 2019; 25(38):4063-84. (PMID: 31553287)
14. Unsworth AJ*, Flora GD*, Gibbins JM. Non-genomic effects of nuclear receptors: insights from the anucleate platelet. Cardiovasc Res, 2018; 114(5):645-55. (PMID: 29452349)
(*Co-First Authors)
15. Holbrook LM, Sandhar GK, Sasikumar P, Schenk MP, Stainer AR, Sahli KA, Flora GD, Bicknell AB, Gibbins JM. A humanized monoclonal antibody that inhibits platelet‐surface ERp72 reveals a role for ERp72 in thrombosis. J Thromb Haemost, 2018; 16(2):367-77. (PMID: 29052936)
16. Unsworth AJ, Flora GD, Sasikumar P, Bye AP, Sage T, Kriek N, Crescente M, Gibbins JM. RXR ligands negatively regulate thrombosis and hemostasis. Arterioscler Thromb Vasc Biol, 2017; 37(5):812-22. (PMID: 28254816)
17. Unsworth AJ, Kriek N, Bye AP, Naran K, Sage T, Flora GD, Gibbins JM. PPARγ agonists negatively regulate αIIbβ3 integrin outside‐in signaling and platelet function through up‐regulation of protein kinase A activity. J Thromb Haemost, 2017; 15(2):356-69. (PMID: 27896950)
18. Moraes LA, Unsworth AJ, Vaiyapuri S, Ali MS, Sasikumar P, Sage T, Flora GD, Bye AP, Kriek N, Dorchies E, Molendi-Coste O, Dombrowicz D, Staels B, Bishop-Bailey D, Gibbins JM. Farnesoid X receptor and its ligands inhibit the function of platelets. Arterioscler Thromb Vasc Biol, 2016; 36(12):2324-33. (PMID: 27758768)
19. Vaiyapuri S, Roweth H, Ali MS, Unsworth AJ, Stainer AR, Flora GD, Crescente M, Jones CI, Moraes LA, Gibbins JM. Pharmacological actions of nobiletin in the modulation of platelet function. Br J Pharmacol, 2015; 172(16):4133-45. (PMID: 25988959)
20. Vaiyapuri S, Flora GD, Gibbins JM. Gap junctions and connexin hemichannels in the regulation of haemostasis and thrombosis. Biochem Soc Trans, 2015; 43(3):489-94. (PMID: 26009196)
21. Gaur N, Flora GD, Yadav M, Tiwari A. A review with recent advancements on bioremediation-based abolition of heavy metals. Environ Sci Process Impacts,2014; 16(2):180-93. (PMID: 24362580)
22. Flora GD, Gupta D, Tiwari A. Preventive efficacy of bulk and nanocurcumin against lead-induced oxidative stress in mice. Biol Trace Elem Res,2013; 152(1):31-40 (PMID: 23292317)
23. Flora GD, Gupta D, Tiwari A. Nanocurcumin: a promising therapeutic advancement over native curcumin. Crit Rev Ther Drug Carrier Syst,2013; 30(4). (PMID: 23662605)
24. Flora GD, Gupta D, Tiwari A. Toxicity of lead: a review with recent updates. Interdiscip Toxicol,2012; 5(2):47. (PMID: 23118587)
25. Flora GD, Bhatt K, Tuteja U. Optimization of culture conditions for poly β-hydroxybutyrate production from isolated Bacillus species. Journal of Cell and Tissue Research, 2010; 10(2): 2235-2242.
Manager, LiveWELL at University of IowaManager, LiveWELL at University of Iowa
Intramural Volleyball at University of IowaIntramural Volleyball at University of Iowa
Director at University of IowaDirector at University of Iowa
Graduate Student Researcher at University of IowaGraduate Student Researcher at University of Iowa
IT Support Consultant at University of Iowa Hospital and ClinicsIT Support Consultant at University of Iowa Hospital and Clinics