Gang Ning

Seasoned Research Scientist and Project Manager with over a decade of experience in genomic medicine, holding a strong record in leading pioneering research initiatives at The Jackson Laboratory for Genomic Medicine (JGM). Notably directed significant genome editing operations and excelled in developing innovative CRISPR-based strategies for genome-wide molecular phenotyping, with a profound impact on neurodegenerative disease research. Demonstrates a robust track record in identifying biomarkers and therapeutic targets for cancer and autism spectrum disorders, enhancing genomic research's clinical applications. Possesses a solid foundation in cell biology and biochemistry with expertise in stem cell culture, molecular characterization, and various gene-editing technologies. Complemented by a suite of interpersonal and leadership skills, adept at managing multidisciplinary teams and complex projects with exceptional reliability.

• Controlling homology-directed repair outcomes in human stem cells with dCas9, Skarnes WC, Ning G, Giansiracusa S, Cruz AS, Blauwendraat C, Saavedra B, Holden K, Cookson MR, Ward ME, McDonough JA, bioRxiv, 2021 Dec 16, 10.1101/2021.12.16.472942
• A novel treatment strategy for lapatinib resistance in a subset of HER2-amplified gastric cancer, Ning G
• Zhu QH
• Kang WY, Lee H, Maher L, Suh YS, Michaud M, Silva M, Kwon JY, Zhang CS, Lee C, BMC Cancer, 2021 Aug 16, 21, 1, 923, 10.1186/s12885-021-08283-9
• Evidence for a novel endometrioid carcinogenic sequence in the fallopian tube with unique beta-catenin expression, Brouwer J, Strickland KC, Ning G, Schmelkin CB, Kolin DL, Hecht J, Nucci MR, Mourits MJ, Xian W, Crum CP, Int J Gynecol Pathol, 2019 Feb 25, 10.1097/PGP.0000000000000590
• Involvement of PKCε in FSH-induced connexin43 phosphorylation and oocyte maturation in mouse, Cai H, Liu B, Yang T, Yang Y, Xu J, Wei Z, Deng G, Ning G, Li J, Wen J, Liu W, Ni Z, Ma Y, Zhang M, Zhou B, Xia G, Ouyang H, Wang C, Biol Open, 2018 Aug 10, 7, 8, bio034678, 10.1242/bio.034678
• Iron addiction: a novel therapeutic target in ovarian cancer, Basuli D, Tesfay L, Deng Z, Paul B, Yamamoto Y, Ning G, Xian W, McKeon F, Lynch M, Crum CP, Hegde P, Brewer M, Wang X, Miller LD, Dyment N, Torti FM, Torti SV, Oncogene, 2017 Jul 20, 36, 29, 4089-4099, 10.1038/onc.2017.11
• In vitro and In vivo correlates of physiologic and neoplastic human fallopian tube stem cells, Yamamoto Y
• Ning G
• Howitt BE, Mehra K, Wu LY, Wang X, Hong Y, Kern Y, Wei TS, Zhang T, Nagarajan N, Torti S, Brewer M, Choolani M, McKeon F, Crum CP, and Xian W, J Pathol, 2016 Mar, 238, 4, 519-530, 10.1002/path.4649
• Cloning and variation of ground state intestinal stem cells, Wang X, Yamamoto Y, Wilson LH, Zhang T, Howitt BE, Farrow MA, Kern F, Ning G, Hong Y, Khor CC, Chevalier B, Bertrand D, Wu L, Nagarajan N, Sylvester FA, Hyams JS, Devers T, Bronson R, Lacy DB, Ho KY, Crum CP, McKeon F, Xian W, Nature, 2015 Jun 11, 522, 7555, 173-8
• The PAX2-null immunophenotype defines multiple lineages with common expression signatures in benign and neoplastic oviductal epithelium, Ning G, Bijron JG, Yamamoto Y, Wang X, Howitt BE, Herfs M, Yang E, Hong Y, Cornille M, Wu L, Hanamornroongruang S, McKeon FD, Crum CP, Xian W, The Journal of Pathology, 2014 Dec, 234, 4, 478-87
• Through the glass darkly: intraepithelial neoplasia, top-down differentiation and the road to ovarian cancer, Crum CP, Herfs M, Ning G, Bijron JG, Howitt BE, Jimenez CA, HanamornroongruangS, McKeon FD, Xian W, The Journal of Pathology, 2013 Sep 13
• Differential Expression of p-ERM, a Marker of Cell Polarity, in Benign and Neoplastic Oviductal Epithelium, Ning G, Bijron J, Yuan J, Hirsch MS, Mckeon FD, Nucci MR, Crum CP, Xian W, The International Journal of Gynecological Pathology, 2013 Jul, 32, 4, 345-52
• Digital quantification of precursor frequency in the oviduct and its significance, Bijron JG, Ning G, Laury AR, Quick CM, Betensky RA, Monte NM, King E, Mckeon FD, Xian W, Crum CP, Modern Pathology, 2012
• Fallopian tube correlates of ovarian serous borderline tumors, Laury AR
• Quick CM, Bijron J, Parast MM, Betensky RA, Vargas SO, McKeon FD, Xian W, Nucci MR, Crum CP, The American Journal of Surgical Pathology, 2011 Dec, 35, 12, 1759-65
• PAX2-null secretory cell outgrowths in the oviduct and their relationship to pelvic serous cancer, Quick CM
• Bijron J, Laury A, Wei TS, Chen EY, Vargas SO, Betensky RA, McKeon FD, Xian W, Crum CP, Modern Pathology, 2012 Mar, 25, 3, 449-55
• STICS, SCOUTs and p53 signatures; a new language for pelvic serous carcinogenesis, Mehra K, Mehrad M, Ning G, Drapkin R, McKeon FD, Xian W, Crum CP, Frontiers Bioscience (Elite Ed), 2011 Jan 1, 3, 625-34
• High-grade fimbrial-ovarian carcinomas are unified by altered p53, PTEN and PAX2 expression, Roh MH, Yassin Y, Miron A, Mehra KK, Mehrad M, Monte NM, Mutter GL, Nucci MR, Ning G, Mckeon FD, Hirsch MS, Wa X, Crum CP, Modern Pathology, 2010 Oct, 23, 10, 1316-24
• A pathologist's road map to benign, precancerous, and malignant intraepithelial proliferations in the fallopian tube, Mehrad M, Ning G, Chen EY, Mehra KK, Crum CP, Advances in Anatomic Pathology, 2010 Sep, 17, 5, 293-302
• Secretory cell outgrowth, PAX2 and serous carcinogenesis in the Fallopian tube, Chen EY, Mehra K, Mehrad M, Ning G, Miron A, Mutter GL, Monte N, Quade BJ, McKeon FD, Yassin Y, Xian W, Crum CP, The Journal of Pathology, 2010 Sep, 222, 1, 110-6
• PDE5 modulates oocyte spontaneous maturation via cGMP-cAMP but not cGMP-PKG signaling, Wang C, Xu B, Zhou B, Zhang C, Yang J, Ouyang H, Ning G, Zhang M, Shen J, Xia G, Frontiers Bioscience, 2008 May 1, 13, 7087-95
• An antisense oligodeoxynucleotide to the LH receptor attenuates FSH-induced oocyte maturation in mice, Yang J, Fu M, Wang S, Chen X, Ning G, Xu B, Ma Y, Zhang M, Xia G, Asian-Australasian Journal of Animal Sciences, 2008 Vol.21 (No.7)
• 3',5'-cyclic adenosine monophosphate response element binding protein up-regulated cytochrome P450 lanosterol 14alpha-demethylase expression involved in follicle-stimulating hormone-induced mouse oocyte maturation, Ning G, Ouyang H, Wang S, Chen X, Xu B, Yang J, Zhang H, Zhang M, Xia G, Molecular Endocrinology, 2008 Jul, 22, 7, 1682-94
• Lanosterol 14alpha-demethylase expression in the mouse ovary and its participation in cumulus-enclosed oocyte spontaneous meiotic maturation in vitro, Wang C, Xie H, Song X, Ning G, Yan J, Chen X, Xu B, Ouyang H, Xia G, Theriogenology, 2006 Sep 15, 66, 5, 1156-64
• Meiosis activating sterol (MAS) regulate FSH-induced meiotic resumption of cumulus cell-enclosed porcine oocytes via PKC pathway, Jin S, Zhang M, Lei L, Wang C, Fu M, Ning G, Xia G, Molecular and Cellular Endocrinology, 2006 Apr 25, 249, 1-2, 64-70