GHOFRAN OTHOUM
Summary
Cancer genomics researcher specializing in proteogenomics, computational biology, and immunopeptidomics. Led the development of reproducible bioinformatics workflows and contributed to NIH-funded translational cancer research, significantly enhancing project outcomes and collaboration within multidisciplinary teams.
Overview
16
16
years of professional experience
Work History
Senior Research Scientist
Washington University School of Medicine & Barnes-Jewish Hospital
01.2024 - Current
- Led computational analyses of clonal evolution in anaplastic thyroid cancer.
- Developed reproducible bioinformatics workflows for translational cancer genomics.
- Collaborated with multidisciplinary clinical and research teams.
Research Scientist
McDonnell Genome Institute, Washington University in St. Louis
01.2023 - 01.2024
- Identified non-canonical coding peptides using integrated proteogenomic analyses.
- Integrated transcriptomic, proteomic and immunopeptidomic datasets.
- Contributed computational methods for cancer antigen discovery.
Postdoctoral Associate
Maher Lab, Washington University in St. Louis
01.2018 - 01.2023
- Developed computational methods for cancer genomics, gene fusion discovery, alternative splicing and proteogenomics.
- Collaborated on NIH-funded translational cancer research projects.
Research Intern
University of California San Diego – Nathan Lewis Lab
01.2016 - 12.2016
- Developed constraint-based metabolic modeling systems for systems biology research.
Research Intern
University of Oxford – OCCAM Mathematical Institute
01.2013 - 12.2013
- Developed mathematical models of the WNT/β-catenin signaling pathway by translating ODE models into Boolean networks.
Research Intern
Dow Chemical
01.2011 - 12.2011
- Performed proteogenomic analyses of microbial communities from oil fields to study corrosion-related biological processes.
Education
PhD - Chemical & Biological Engineering
KAUST
01-2018
MSc - Bioscience
KAUST
01-2013
BSc - Computer Science
Effat University
01-2011
Skills
- Python
- R
- Bash
- Snakemake
- Nextflow
- RNA-seq
- ScRNA-seq
- WGS/WES
- Long-read sequencing
- Proteogenomics
- Immunopeptidomics
- Variant Calling
- Clonal Evolution
- HPC
- Git
Awards And Teaching
Retain existing awards and mentoring sections.
Degree
PhD
Publications
Retain the complete publication list from your current CV without modification.
Research Internships
- Research Intern, University of California San Diego – Nathan Lewis Lab, La Jolla, CA, 01/01/16, 12/31/16, Developed constraint-based metabolic modeling systems for systems biology research.
- Research Intern, University of Oxford – OCCAM Mathematical Institute, Oxford, OX, 01/01/13, 12/31/13, Developed mathematical models of the WNT/β-catenin signaling pathway by translating ODE models into Boolean networks.
- Research Intern, Dow Chemical, 01/01/11, 12/31/11, Performed proteogenomic analyses of microbial communities from oil fields to study corrosion-related biological processes.
Research Interests
- Cancer Genomics
- Proteogenomics
- Multi-omics Integration
- Immunopeptidomics
- Clonal Evolution
- Computational Biology
Timeline
Senior Research Scientist
Washington University School of Medicine & Barnes-Jewish Hospital
01.2024 - Current
Research Scientist
McDonnell Genome Institute, Washington University in St. Louis
01.2023 - 01.2024
Postdoctoral Associate
Maher Lab, Washington University in St. Louis
01.2018 - 01.2023
Research Intern
University of California San Diego – Nathan Lewis Lab
01.2016 - 12.2016
Research Intern
University of Oxford – OCCAM Mathematical Institute
01.2013 - 12.2013
Research Intern
Dow Chemical
01.2011 - 12.2011
PhD - Chemical & Biological Engineering
KAUST
MSc - Bioscience
KAUST
BSc - Computer Science
Effat University