Chi Woo (Nate) Yoon

Innovative bioengineer with over ten years of research experience in ultrasound engineering, synthetic/genetic engineering, and immunotherapy. Proven expertise in advanced cell biology techniques, including 3D organoid models, multicellular spheroids, and cell engineering techniques such as CRISPR. Demonstrated leadership in managing interdisciplinary teams and developing new research projects through collaborations. Committed to advancing cutting-edge biomedical solutions in a fast-paced, collaborative environment.

• Best Poster Award, 20th Annual Fred S. Grodins Research Symposium (2016)
• Alfred E. Mann Institute (AMI) Award, Viterbi School of Engineering (2017)
• NCI T32 Cancer Cell Signaling & Communication Training Grant, National Institutes of Health (2021)

• Yoon, C.W., Song, C., Nguyen, D.N.M., et al. (2024). Tumor Priming by Ultrasound Mechanogenetics for SynNotch CAR T Therapy. Nature Materials. [Under Revision].
• Wu, Y., Huang, Z., Liu, Y., He, P., Wang, Y., Yan, L., Wang, X., Gao, S., Zhou, X., Yoon, C.W., et al. (2024). Ultrasound Control of Genomic Regulatory Toolboxes for Cancer Immunotherapy. Nature Communications 15.
• Liu, L., Yoon, C.W., Yuan, Z., et al. (2023). Cellular and molecular imaging of CAR-T cell-based immunotherapy. Adv Drug Deliv Rev 203. *Co-first
• Yoon, C.W., Pan, Y., and Wang, Y. (2022). The application of mechanobiotechnology for immuno-engineering and cancer immunotherapy. Frontiers in Cell and Developmental Biology 10.
• Liu, L., Qu, Y., Cheng, L., Yoon, C.W., He, P., Monther, A., et al. (2022). Engineering chimeric antigen receptor T cells for solid tumour therapy. Clin Transl Med 12(12), e1141.
• Pan, Y., Shi, L.Z., Yoon, C.W., Preece, D., Gomez-Godinez, V., Lu, S., et al. (2022). Mechanosensor Piezo1 mediates bimodal patterns of intracellular calcium and FAK signaling. EMBO J 41(17), e111799.
• Zhu, L., Wu, Y., Yoon, C.W., and Wang, Y. (2020). Mechanogenetics for cellular engineering and cancer immunotherapy. Current Opinion in Biotechnology 66, 88-94.
• Lee, N.S., Yoon, C.W., Wang, Q., Moon, S., Koo, K.M., Jung, H., et al. (2020). Focused Ultrasound Stimulates ER Localized Mechanosensitive PANNEXIN-1 to Mediate Intracellular Calcium Release in Invasive Cancer Cells. Front Cell Dev Biol 8, 504.
• Lim, H.G., Liu, H.-C., Yoon, C.W., Jung, H., Kim, M.G., Yoon, C., et al. (2020). Investigation of cell mechanics using single-beam acoustic tweezers as a versatile tool for the diagnosis and treatment of highly invasive breast cancer cell lines: an in vitro study. Microsystems & Nanoengineering 6(1).
• Yoon, C.W., Lee, N.S., Koo, K.M., Moon, S., Goo, K., Jung, H., et al. (2020). Investigation of Ultrasound-Mediated Intracellular Ca(2+) Oscillations in HIT-T15 Pancreatic beta-Cell Line. Cells 9(5).
• Yoon, C.W., Jung, H., Goo, K., Moon, S., Koo, K.M., Lee, N.S., et al. (2017). Low-Intensity Ultrasound Modulates Ca2+ Dynamics in Human Mesenchymal Stem Cells via Connexin 43 Hemichannel. Ann Biomed Eng.
• Weitz, A.C., Lee, N.S., Yoon, C.W., Bonyad, A., Goo, K.S., Kim, S., et al. (2017). Functional Assay of Cancer Cell Invasion Potential Based on Mechanotransduction of Focused Ultrasound. Front Oncol 7, 161.
• Hwang, J.Y., Yoon, C.W., Lim, H.G., Park, J.M., Yoon, S., Lee, J., et al. (2015). Acoustic tweezers for studying intracellular calcium signaling in SKBR-3 human breast cancer cells. Ultrasonics 63, 94-101.
• Hwang, J.Y., Lim, H.G., Yoon, C.W., Lam, K.H., Yoon, S., Lee, C., et al. (2014). Non-contact high-frequency ultrasound microbeam stimulation for studying mechanotransduction in human umbilical vein endothelial cells. Ultrasound Med Biol 40(9), 2172-2182.
• Lee, B.S., Amano, T., Wang, H.Q., Pantoja, J.L., Yoon, C.W., Hanson, C.J., et al. (2013). Reactive oxygen species responsive nanoprodrug to treat intracranial glioblastoma. ACS Nano 7(4), 3061-3077.
• Lee, B.S., Yoon, C.W., Osipov, A., Moghavem, N., Nwachokor, D., Amatya, R., et al. (2011). Nanoprodrugs of NSAIDs: Preparation and Characterization of Flufenamic Acid Nanoprodrugs. J Drug Deliv 2011, 980720.