HIRAL RAJU MEHTA
Orlando,USA
Summary
PhD Candidate in Pharmacometrics specializing in Population and Physiologically Based Pharmacokinetic (PopPK and PBPK) modeling, with a strong foundation in clinical pharmacology and translational research.
Overview
5
5
years of professional experience
Work History
PhD Researcher – Pharmacometrics
Center for Pharmacometrics and Systems Pharmacology (CPSP), University of Florida
01.2024 - Current
- Developing a mechanistic PBPK/PD modeling framework to assess the impact of inflammatory conditions on hepatocellular statin exposure, linking PBPK-predicted intracellular hepatic concentrations to pharmacodynamic response.
- Developing population PK models to characterize site-specific tumor and systemic disposition of nimotuzumab in epithelial-origin cancers, incorporating sources of interindividual variability in tumor exposure.
- Developing a comprehensive PBPK parameter database for twin pregnancy populations, integrating gestational age–dependent physiological and biochemical parameters.
Research Fellow and Vaccinator Officer
Tata Memorial Hospital
Mumbai, India
11.2021 - 09.2022
- Co-investigator in studies identifying causative organisms of sepsis in ALL patients and developing predictive algorithms for febrile neutropenia management.
- Led a collaborative project with IIT-Bombay to design a PET-CT and pathology-based risk prediction model for advanced Hodgkin Lymphoma.
- Drafted multiple clinical research protocols and presented monthly antibiotic stewardship audits.
Lecturer and Preceptor
Sri Ramakrishna Institute of Paramedical Sciences
Coimbatore, India
02.2021 - 10.2021
- Taught Human Anatomy and Physiology to a class of 96 undergraduate students.
Education
Ph.D. - Pharmacometrics
University of Florida, College of Pharmacy
02-2026
Doctor of Pharmacy (Pharm.D.) - undefined
The Tamil Nadu Dr. M.G.R. Medical University
India01-2020
Skills
- Population and PBPK modeling (Simcyp, Monolix, Pumas AI or R-based analysis)
- Clinical trial design, Protocol drafting
- Performed pharmacokinetic modeling and simulation based on Gabrielsson and Weiner’s framework, reinforcing core principles of model development
- Leadership, communication, time management, and problem-solving
Interests
Trained Hindustani classical vocalist (6 years, Temple of Fine Arts, Coimbatore)
Timeline
PhD Researcher – Pharmacometrics
Center for Pharmacometrics and Systems Pharmacology (CPSP), University of Florida
01.2024 - Current
Research Fellow and Vaccinator Officer
Tata Memorial Hospital
11.2021 - 09.2022
Lecturer and Preceptor
Sri Ramakrishna Institute of Paramedical Sciences
02.2021 - 10.2021
Doctor of Pharmacy (Pharm.D.) - undefined
The Tamil Nadu Dr. M.G.R. Medical University
Ph.D. - Pharmacometrics
University of Florida, College of Pharmacy
PUBLICATIONS
- Jain H, Rajendra A, Sengar M, Goli VB, Thorat J, Muthuluri H, Tongaonkar AH, Kota KK, Gupta H, Sharma N, Eipe T, Mehta H. The current treatment approach to adolescents and young adults with acute lymphoblastic leukemia (AYA-ALL): challenges and considerations. Expert Rev Anticancer Ther. 2022 Aug; 22(8):845- 860. doi: 10.1080/14737140.2022.2093718.
- Jain H, Singh A, Sengar M, Eipe T, Mehta H, Bagal B, Thorat J, Nayak L, Sharma N. P003: A retrospective study to evaluate the reliability of staging and risk stratification of adolescent and adult patients with Hodgkin’s lymphoma registered in the lymphoma clinic at Tata Memorial Centre. Hemasphere. 2022 Oct 3;6(Suppl):2. doi: 10.1097/01.HS9.0000890580.06077.ee.
- Impact of Pharmacist’s Integrated Care (PIC) on Diastolic Performance Index (DPI) in patients with Cardiovascular Diseases. (In review, Springer)
CERTIFICATIONS & CONFERENCES
- Workshop: Pharmacometric Modeling & Simulation (PUMAS Software)
- Introduction to PBPK Modelling by Certara
- Beginning and Intermediate Workshop in PDx-PopTM and NONMEM by ICON
- Coursera: Introduction to the Biology of Cancer
- Poster Presenter, ACCP 2025: “Utilizing PBPK Modeling to Evaluate the Effects of Inflammatory Conditions on Hepatocellular Statin Exposure and Pharmacodynamic Response”
ORGANIZATIONAL & COMMUNITY ACTIVITIES
- Student Head, NSS campaign in adopted villages, Coimbatore, India
- Led university health awareness drives for HIV, TB, and cancer
- Organized fundraising events for orphanage infrastructure improvements