Ho-Sup Lee
San Diego,CA
Summary
Accomplished scientist with 15+ years of expertise in integrin biology and GPCR pharmacology, driving innovation in cardiovascular biology, immunology, and therapeutic discovery. Proven leader in molecular biology, protein engineering, and assay development, with a track record of advancing receptor biology programs and drug discovery pipelines. Skilled in translating complex signaling insights into therapeutic applications, mentoring cross-functional teams, and delivering solutions that support biomarker identification and translational research.
Overview
23
23
years of professional experience
Work History
Project Lead, Protein Science & Functional Biology
UC San Diego
La Jolla, CA
01.2006 - Current
- Directed cross-functional teams to advance receptor biology research (integrins, GPCRs), aligning discoveries with translational cardiovascular programs.
- Engineered and optimized protein constructs through rational design and directed evolution, improving stability and function for therapeutic development.
- Developed innovative assays to characterize protein-glycosaminoglycan interactions, enabling identification of novel biomarkers relevant to cardiovascular and immunology programs.
- Applied advanced molecular biology tools (CRISPR/shRNA, mutagenesis) to functional studies in translational cell systems, supporting target validation.
- Managed protein purification pipelines (affinity chromatography, FPLC), increasing throughput and reproducibility for structural and functional analyses.
- Mentored junior scientists and fostered collaborative, multidisciplinary research environments, strengthening team performance and knowledge transfer.
- Published and presented research outcomes globally, demonstrating strong communication skills and ability to translate complex data into actionable insights.
Postdoctoral Fellow
Northwestern University
01.2003 - 01.2005
- Discovered regulatory mechanisms of cytoskeletal proteins, contributing to drug target validation strategies.
- Applied molecular biology and protein engineering techniques to receptor biology studies.
- Published findings in peer-reviewed journals and presented at international conferences.
Education
Ph.D. - Molecular, Cellular & Developmental Biology and Neuroscience
Iowa State University
Ames, IA01.2002
M.S. - Microbial Genetics/Genetic Engineering
Kyungpook National University
South Korea02-1991
B.S. - Genetic Engineering
Kyungpook National University
South Korea02-1989
Skills
- Advanced DNA assembly
- CRISPR/shRNA gene editing
- Molecular cloning
- Site-directed mutagenesis
- Flow cytometry
- Functional immunoassays
- Mammalian cell culture
- T cell signaling pathway analysis
- Transfection
- Analysis of protein-glycosaminoglycan interactions
- Integrin & GPCR Signaling Pathways
- Proteomics
- Target validation
- Protein Expression & Engineering
- Protein purification using affinity tags
- Modified In-cell ELISA
- Split tandem tag affinity purification
- ELISA
- Immunoprecipitation
- Western Blot
- Chromatography
- Fluorescence polarization
- Data processing
- FlowJo
- GraphPad Prism
- ImageJ/Fiji
- PyMOL
- R for protein modeling
- Contributions to intellectual property
- Cross-functional collaboration
- Grant writing
- Project strategy development
- Publications
Publications
Authored 15+ peer-reviewed publications in high impact journals.
Skills
advanced DNA assembly for antibody and receptor constructs, CRISPR/shRNA gene editing, molecular cloning, site-directed mutagenesis, flow cytometry, functional immunoassays, Mammalian cell culture, T cell signaling pathway analysis, transfection, analysis of protein-glycosaminoglycan interactions, Integrin & GPCR Signaling Pathways, proteomics, target validation, Protein Expression & Engineering, protein purification using affinity tags, modified In-cell ELISA, Split tandem tag affinity purification, ELISA, Flow Cytometry, Immunoprecipitation, Western Blot, Chromatography, Fluorescence Polarization, data processing, FlowJo, GraphPad Prism, ImageJ/Fiji, PyMOL, R for protein modeling, contributions to intellectual property, cross-functional collaboration, grant writing, project strategy development, publications
Awards And Scholarships
Scientist Development Award, 12/2013, American Heart Association
Languages
Korean
Full Professional
Accomplishments
Scientist Development Award - American Heart Association 2013
References
References available upon request.
Timeline
Project Lead, Protein Science & Functional Biology
UC San Diego
01.2006 - Current
Postdoctoral Fellow
Northwestern University
01.2003 - 01.2005
Ph.D. - Molecular, Cellular & Developmental Biology and Neuroscience
Iowa State University
M.S. - Microbial Genetics/Genetic Engineering
Kyungpook National University
B.S. - Genetic Engineering
Kyungpook National University