Dynamic Postdoctoral Researcher with extensive detailed research protocols and experiment experience. I received interdisciplinary training in metabolic disease pathophysiology, glucose and lipid metabolism regulation and molecular biology. I am passionate about developing new biochemical assays and pursuing the role of glucose and lipid metabolism in metabolic diseases and associated cancer using multi-omics approach.
Molecular biology skills
Mouse experiment skills
Character
1. Hong Yu#, Hong-Ying Gao#, Hua Guo, Gui-Zhen Wang, Yi-Qing Yang, Li-Jun Liang, Qun Zhao, Da-Wei Xie, Yu Rao*, Guang-Biao Zhou*,Upregulation of wild-type p53 by small molecule-induced elevation of NQO1 in non-small cell lung cancer cells,Acta Pharmacologica Sinica. 2021.
2. Liang, Li-Jun#; Yang, Fu-Ying#; Wang, Di#; Zhang, Yan-Fei#; Yu, Hong; Wang, Zheng; Sun, Bei-Bei; Liu, Yu-Tao; Wang, Gui-Zhen; Zhou, Guang-Biao*,CIP2A induces PKM2 tetramer formation and oxidative phosphorylation in non-small cell lung cancer. Cell Discovery. 2024.
3. Zhao, Peng#; Sun, Xiaoli; Liao, Zhongji; Yu, Hong; Li, Dan; Shen, Zeyang; Glass, Christopher K; Witztum, Joseph L; Saltiel, Alan R*,The TBK1/IKKε inhibitor amlexanox improves dyslipidemia and prevents atherosclerosis. JCI insight. 2022.
4. Guizhen Wang#, Qun Zhao, Fan Liang, Chen Zhang, Hui Zhang, Jun Wang,Zhenyin Chen, Ran Wu, Hong Yu, Beibei Sun, Hua Guo, Ruie Feng, Kaifeng Xu, Guangbiao Zhou*,Degradation of SARS-CoV-2 receptor ACE2 by the E3 ubiquitin ligase Skp2 in lung epithelial cells. Front Med. 2021.
5. Zhao XC#, Wang GZ#, Wen ZS#, Zhou YC#, Zhao XC, Wang GZ, Wen ZS, Zhou YC, Hu Q, Zhang B, Qu LW, Gao SH, Liu J, Ma L, Zhang YF, Zhang C, Yu H, Zhang DL, Wang M, Wang CL, Huang YC, Liu ZH, Zhao Y, Chen L, Zhou GB*. Systematic identification of CDC34 that functions to stabilize EGFR and promote lung carcinogenesis. EBioMedicine. 2020; 53: 102689.
6. Zhao XC#, Yongchun Z, Qian H, Sanhui G, Jie L, Hong Y, Yanfei Z, Guizhen W, Yunchao H, Guangbiao Z*. Identification of a potential tumor suppressor gene, UBL3, in non-small cell lung cancer. Cancer Biol Med. 2020; 17: 76-87.
7. Wang M#, Yu H, Wu R, Chen ZY, Hu Q, Zhang YF, Gao SH, Zhou GB*. Autophagy inhibition enhances the inhibitory effects of ursolic acid on lung cancer cells. Int J Mol Med. 2020; 46: 1816-1826.
8. Wang GZ#, Zhang L#, Zhao XC#, Gao SH#, Qu LW, Yu H, Fang WF, Zhou YC, Liang F, Zhang C, Huang YC, Liu Z, Fu YX, Zhou GB*. The Aryl hydrocarbon receptor mediates tobacco-induced PD-L1 expression and is associated with response to immunotherapy. Nat Commun. 2019; 10: 1125.
9. Da-Lin Zhang#, Li-Wei Qu#, Liang Ma, Yong-Chun Zhou, Gui-Zhen Wang, Xin-Chun Zhao, Chen Zhang, Yan-Fei Zhang , Min Wang, Mei-Ying Zhang, Hong Yu , Bei-Bei Sun, San-Hui Gao, Xin Cheng, Ming-Zhou, Yun-Chao Huang, Guang-Biao Zhou*, Genome-wide identification of transcription factors that are critical to non-small cell lung cancer[J]. Cancer Lett, 2018, 434: 132-143.