Hossein Rahimi
Summary
Experienced with microbial diagnostics, infection control, and laboratory procedures. Utilizes molecular techniques to identify and analyze pathogens effectively. Knowledge of aseptic techniques and collaborative teamwork fosters high-quality patient care and research outcomes.
Overview
6
6
years of professional experience
Work History
Postdoctoral Researcher
Department of Microbiology and Immunology, Stony Brook University
Stony Brook, NY, USA
11.2022 - Current
- - Conducted NIH-funded research on IL-17 receptor signaling in kidney immunity and inflammation, with a focus on antifungal host defense mechanisms and chronic kidney disease pathogenesis.
- - Investigated the role of Nfkbiz gene in immune responses against Candida albicans infection using conditional knockout (cdh16-cre) mouse models.
- - Assessed renal immune responses, neutrophil infiltration, cytokine expression (TNF-α, IL-1β, IL-6), and apoptosis via qPCR, IHC, H&E staining, and TUNEL assays.
- - Conducted in vitro infection models using HK-2 kidney epithelial cells to analyze cytokine responses and fungal burden.
- - Performed flow cytometry and ELISA for immune profiling and cytokine quantification.
- - Contributed to grant writing and manuscript development related to IL-17-mediated renal immune protection.
- - Collaborated on projects involving glucose transporter-1 (Glut1) and neutrophil metabolism in autoimmune glomerulonephritis (AGN).
- - Participated in training and mentorship of rotation students and junior researchers in experimental design and data analysis.
Microbiology Researcher
Ministry of Agriculture, Irrigation and Livestock
Kabul, Afghanistan
06.2020 - 07.2021
- - Controlled food microbial contaminants
- - Recognized pathogenesis of microorganisms in reference samples
- - Assessed medicinal sensitivity of pathogen samples
- - Utilized standard methods for diagnosing pathogenic bacteria
Faculty member
Department of Biology and Microbiology, Khatam-Alnabeeen University
Kabul, Afghanistan
10.2019 - 01.2021
- - Taught microbiology theory and practical laboratory courses to undergraduate students.
- - Provided guidance and advice for student research
- - Trained students in specialized workshops
- - Supervised proper performance of training laboratories
- - Oversaw all educational and research programs
Education
PhD - Medical Mycology
Tarbiat Modares University
01.2020
Master's - Medical Mycology
Tarbiat Modares University
01.2011
Bachelor's - Veterinary Laboratory Sciences
Zabul University
01.2007
Skills
- Molecular Biology: DNA/RNA extraction, qPCR, PCR genotyping, agarose gel electrophoresis
- Protein & Cell Analysis: Western blot, ELISA, immunohistochemistry (IHC), TUNEL assay, flow cytometry
- Histology: Tissue sectioning, H&E staining, immunofluorescence, kidney pathology scoring
- Cell Culture: Maintenance of HK-2 epithelial cells, fungal co-culture assays, cytokine stimulation
- Microbiology & Mycology: Pathogen handling, antifungal susceptibility testing, fungal burden assays
- Data & Research: GraphPad Prism, microscopy image analysis, grant/manuscript writing
- Animal Work: Mouse handling, genotyping (conditional knockout), infection models, kidney harvesting
- Teaching & Mentorship: Guided undergraduate and graduate students, led workshops
- Molecular Biology: DNA extraction and purification, qPCR, Electrophoresis, Western blot, SDS-PAGE, Cell culture, Electron microscopy, Immunohistochemistry, ELISA, Flow cytometry
- Research
Publications
- Rahimi, H., Choi, W., Mac Ghilin, C., Jawale, C. V., Biswas, P. Divergent and StageSpecific Regulation of Neutrophil Function by Glucose Transporter 1 in Antibody mediated Glomerulonephritis (Submitted to JCI journal)
- Rahimi, H., Choi, W., Mac Ghilin, C., Biswas, P. The Nfkbiz Gene as a Key Player in Renal Tubular Epithelial Cell-Mediated Immunity During Candida albicans Kidney Infection (Manuscript in Preparation)
- Peroumal, D., Jawale, C. V., Choi, W., Rahimi, H., Antos, D., Li, D.-d., Wang, S., Manakkat Vijay, G. K., Mehta, I., West, R., Thangaraju, M., Nolin, T. D., Das, J., Alcorn, J. F., & Biswas, P. S. (2024). The survival of B cells is compromised in kidney disease ,Nature Communications, Volume(15)
- Ghazizadeh, E., Naseri, Z., Deigner, H.-P., Rahimi, H., & Altintas, Z. (2024). Approaches of wearable and implantable biosensors towards developing precision medicine. Frontiers in Medicine,Volume(11) https://doi: 10.3389/fmed.2024.1390634
- Rahimi, H., Roudbarmohammadi, S., Delavari, H., & Roudbary, M. (2019). Antifungal effects of indolicidin-conjugated gold nanoparticles against fluconazole-resistant strains of Candida albicans isolated from patients with burn infections. International Journal of Nanomedicine, Volume(14)
- Hossein Rahimi, Roudbarmohammadi,S., Reza Kachouei, Maryam Roudbari.(2013). Expression of Candida albicans ALS 2 and ALS 9 Genes Isolated from Women with Vaginal Candidiasis by RT-PCR. Modares Journal of Medical Sciences: Pathobiology, Vol (16).
Timeline
Postdoctoral Researcher
Department of Microbiology and Immunology, Stony Brook University
11.2022 - Current
Microbiology Researcher
Ministry of Agriculture, Irrigation and Livestock
06.2020 - 07.2021
Faculty member
Department of Biology and Microbiology, Khatam-Alnabeeen University
10.2019 - 01.2021
Master's - Medical Mycology
Tarbiat Modares University
Bachelor's - Veterinary Laboratory Sciences
Zabul University
PhD - Medical Mycology
Tarbiat Modares University