Jacob Salvatore
Cambridge,MA
Summary
Experienced Engineer with a robust background in process development and biotechnology, specializing in CAR-T Manufacturing and Genotoxicity analysis. Expert in mammalian cell culture and flow cytometry, coupled with exceptional project management and data presentation skills. Demonstrated success in advancing ex vivo therapies through innovative research and robust process development.
Overview
5
5
years of professional experience
Work History
Engineer I
Intellia Therapeutics
Cambridge, MA
07.2022 - 01.2025
- Execute small scale experiments to support various ex vivo pipeline therapies
- Improvement of the small- scale model of CAR T Manufacturing Process
- Collect mid- and end-point process analytics via spent media analysis and flow cytometry
- Support incoming apheresis material processing and T-Cell preservation to support future small- and large- scale experiments
- Assembly of complete genotoxicity package for IND filing
- On- and off- target gDNA collection for sequencing and further analysis
Associate Engineer- Upstream Process Development
Rubius Therapeutics
Cambridge, MA
06.2021 - 06.2022
- Establish, optimize, and develop robust bioreactor processes through careful and targeted experimentation
- Complete GMP caliber experiments and accompanying documentation
- Collect and prepare data to be effectively presented at company meetings
Graduate Research and Teaching Assistant
Duquesne University
Pittsburgh, PA
06.2020 - 05.2021
- Completion of coursework and accompanying research for master's thesis
- Exhaustive Literature Analysis to Inform Research
- Successful Presentation and Defense of Master's Thesis
- Guided and managed research initiatives undertaken by undergraduate students
- Occasionally facilitated career- focused seminars for senior engineering students
Education
Master of Science - Biomedical Engineering
Duquesne University
Pittsburgh, PA05-2021
Bachelor of Science - Biomedical Engineering
Duquesne University
Pittsburgh, PA05-2020
Skills
- Mammalian cell culture (stem cells, T cells, specialized tissues, etc)
- Flow Cytometry and Panel Development
- Leukapheresis Collection, Processing, Preservation
- Molecular Biology Techniques (PCR, sterile technique, etc)
- Lab Operations (Organization, Equipment Maintenance,
- Engineering skills (process development, experimental design, data interpretation)
- Project management skills (timeline development, task organization, document life cycle management)
- Effective Data Presentation
Affiliations
- Eagle Scout
- Phi Kappa Theta Fraternity, Former Treasurer & Head of Philanthropy
- Avid runner that has completed 10 marathons
Timeline
Engineer I
Intellia Therapeutics
07.2022 - 01.2025
Associate Engineer- Upstream Process Development
Rubius Therapeutics
06.2021 - 06.2022
Graduate Research and Teaching Assistant
Duquesne University
06.2020 - 05.2021
Master of Science - Biomedical Engineering
Duquesne University
Bachelor of Science - Biomedical Engineering
Duquesne University
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