Jacqueline Frost

Experienced scientist with a strong background in research and analysis. Proficient in experimental design, data analysis, and interpretation across various scientific disciplines. Demonstrated ability to contribute to impactful research projects and collaborate effectively with interdisciplinary teams.

• 1. Liu, X., Frost, J., Bowcock, A. and Zhang, W., 2021. Canonical and Interior Circular RNAs Function as Competing Endogenous RNAs in Psoriatic Skin. International journal of molecular sciences, 22(10), p.5182.
• 2. Mpangase, P.T., Frost, J., Ramsay, M. and Hazelhurst, S., 2020. nf-rnaSeqMetagen: A nextflow metagenomics pipeline for identifying and characterizing microbial sequences from RNA-seq data. Medicine in Microecology, 4, p.100011.
• 3. Sundberg, J.P., Pratt, C.H., Silva, K.A., Kennedy, V.E., Qin, W., Stearns, T.M., Frost, J., Sundberg, B.A. and Bowcock, A.Μ., 2019. Gain of function p. E138A alteration in Card14 leads to psoriasiform skin inflammation and implicates genetic modifiers in disease severity. Experimental and molecular pathology, 110, p.104286.
• 4. Frost, J., Estivill, X., Ramsay, M. and Tikly, M., 2019. Dysregulation of the Wnt signaling pathway in South African patients with diffuse systemic sclerosis. Clinical rheumatology, 38(3), pp.933-938.
• 5. Govind, N., Choudhury, A., Hodkinson, B., Ickinger, C., Frost, J., Lee, A., Gregersen, P.K., Reynolds, R.J., Bridges Jr, S.L., Hazelhurst, S. and Ramsay, M., 2014. Immunochip identifies novel, and replicates known, genetic risk loci for rheumatoid arthritis in black South Africans. Molecular Medicine, 20(1), p.341.
• 6. Frost, J., Ramsay, M., Mia, R., Moosa, L., Musenge, E. and Tikly, M., 2012. Differential gene expression of MMP-1, TIMP-1 and HGF in clinically involved and uninvolved skin in South Africans with SSc. Rheumatology, 51(6), pp.1049- 1052.
• 7. Niewold, T.B., Kelly, J.A., Kariuki, S.N., Franek, B.S., Kumar, A.A., Kaufman, K.M., Thomas, K., Walker, D., Kamp, S., Frost, J.M. and Wong, A.K., 2011. IRF5 haplotypes demonstrate diverse serological associations which predict serum interferon alpha activity and explain the majority of the genetic association with systemic lupus erythematosus. Annals of the rheumatic diseases, 71(3), pp.463-469.
• 8. Tikly, M., Govind, N., Frost, J. and Ramsay, M., 2009. The PTPN22 R620W polymorphism is not associated with systemic rheumatic diseases in South Africans. Rheumatology, 49(4), pp.820-821

• 2020-2021: Early Career Research Grant from the National Psoriasis Foundation ($50 000)
• 2008-2017: Research Funding: University Research Grants, Medical Council of South Africa (MRC), NHLS Research Trust (>R400 000, between 2008 and 2017)
• 2013-2015: National Research Foundation Innovation Scholarship. Stipend for three years and International travel grant (Top 2% of applicants)
• 2013: CRG-Novartis-Wits Scientist Exchange in Barcelona, Spain. Bench fees, monthly stipend and housing (3 awards for ~100 applicants)
• 2010: Travel grant to attend the EULAR conference in Rome, Italy. Registration, accommodation and stipend (Top 10% of applicants)
• 2006: Postgraduate Merit Award. Stipend and tuition fees (Top 5% of applicants)
• 2001: Academic Achievement Scholarship. Tuition fees (Top 2% of applicants)

Invited Reviewer Serve as a reviewer for peer-review publications for Clinical Rheumatology and Frontiers in Genetics Chaired and participated in review panels to critique applications for National and International PhD/Postdoctoral awards in the fields of Molecular Biology, Bioinformatics, Biotechnology, Physics, Mathematics and Statistics. Chairperson of the Young Researchers Forum (YRF) Led a team to organize a one-day symposium Took initiative to obtain backing and support from Biotechnology companies to secure sponsorship Committees at the University of the Witwatersrand Faculty of Health Sciences' Postgraduate Representative (elected) serving on the Postgraduate Committee As a faculty member I served on the Undergraduate Studies Committee and School of Pathology Review Committee