JAE H. CHOI
Rockton,IL
Summary
As a highly skilled scientist with a PhD in Biological Chemistry and extensive experience in proteomics, mass spectrometry, and targeted assay development, I have contributed to groundbreaking research and product development in both academic and industry settings. My goal is to leverage my expertise in protein biochemistry and molecular/cell biology to drive innovation in R&D, ultimately advancing scientific discovery and delivering impactful solutions in the biotechnology sector.
Overview
25
25
years of professional experience
1
1
Certification
Work History
Adjunct Assistant Professor
University of Illinois at Chicago
09.2010 - Current
- Responsibilities
- Lecturer: graduate-level cell biology class in Spring
- Lab coordinator: graduate level cell-based assay laboratory class in fall semester.
Staff Scientist, Scientist III, Scientist II
Thermo Fisher Scientific
Rockford, IL
06.2010 - Current
- Responsibilities
- At Thermo Fisher Scientific, I led the development and commercialization of over 20 mass spectrometry reagents, including phosphopeptide enrichment kits and TMT standards, calibrants, system suitability standard and heavy peptide mixture for targeted assay. I played a key role in designing host cell protein assays and supported custom peptide businesses by peptide analysis. My work directly contributed to the advancement of innovative solutions in mass spectrometry and proteomics.
- Key achievements
- Successfully developed and launched multiple mass spectrometry reagent products, including phosphopeptide enrichment kits (cat. No; A32992, A32993), TMT standards (Cat. No. 40938) and protein digest standards (cat. No. A47996, A47951) contributing to increased market share.
- Technologies, tools, or methodologies used: DDA and DIA acquisition for Orbitrap Eclipse, Fusion, Exploris 480, QE plus.
- Developed and launched Small molecule system suitability standard (cat. No. A51740)
- Technologies, tools, or methodologies used: targeted assay for TSQ triple Quadrupole platform.
- Launched Aquaporin Z protein standard (Cat.no. A66693)
- Technologies, tools, or methodologies used: Q Exactive UHMR native protein analysis
- Plan to commercialize a targeted assay and sample prep kit for host cell proteins (HCPs) (2025 product)
- Technologies, tools, or methodologies used: PRM targeted assay for Orbitrap Eclipse, Exploris 480, QE plus.
- Collaborated with external partners in beta testing, ensuring the reliability and wide applicability of new mass spectrometry tools.
- Led customer-driven innovation through direct collection of voice-of-customer feedback, enhancing the product portfolio in alignment with industry needs.
- Non-provisional patent filing: TP386565USPRV2 : “METHODS AND COMPOSITIONS FOR ANALYZING HOST CELL PROTEINS”
Research Fellow
NIH, Research Triangle Park
Research Triangle Park, NC
05.2004 - 05.2010
- Responsibilities and Key achievements
- At the National Institutes of Health (NIH/NIEHS), I purified and cloned the enzyme 'InsP7 kinase' from rat brain tissue and identified two human homologs, PPIP5K1 and PPIP5K2. I investigated the molecular mechanisms regulating InsP7 kinase activity and explored the biological functions of its enzymatic product, 'InsP8', through extensive collaboration with the Mass Spectrometry Group. This work resulted in four publications in peer-reviewed journals such as the Journal of Biological Chemistry and Molecular Pharmacology.
Scientist II
Myriad Proteomics
Salt Lake City, TU
03.2001 - 04.2004
- Responsibilities and Key achievements
- At Myriad Proteomics, I identified potential drug targets in colon cancer area and validated protein-protein interactions as druggable targets using luciferase reporter assays, BRET assays, and RNAi technology. I also conducted data-mining on key signaling pathways, including PI3-kinase/PTEN & mTOR area and identified novel cancer drug targets through proprietary protein-protein interaction database.
Education
M.B.A -
Rockford University
Rockford, ILPh.D. - undefined
St. John’s University
Queens, NYB.S. - undefined
Michigan State University
East Lansing, MISkills
- Proteomics
- DDA, DIA, PRM: Orbitrap Eclipse, Fusion, Exploris 480, QE plus for discovery & targeted
- Native structural analysis: Q Exactive UHMR
- Ultimate 3000 & Vanquish Neo LC & Vanquish Flex
- Small molecule analysis: TSQ triple quadrupole
- Cell Biology
- Cell culture (mammalian, insect, yeast and bacterial culture)
- Cell-based assay development for target validation and HTS
- Molecular biology
- Molecular cloning
- QPCR
Affiliations
- [Organization Name] – Member since [Year]
- [Another Organization] – Member since [Year]
Certification
- [Certification Name] – [Issuing Organization]
- [Month/Year]
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Awards
[Award Title] – [Month/Year], Brief description or significance., [Another Award] – [Month/Year], Description if needed.
Timeline
Adjunct Assistant Professor
University of Illinois at Chicago
09.2010 - Current
Staff Scientist, Scientist III, Scientist II
Thermo Fisher Scientific
06.2010 - Current
Research Fellow
NIH, Research Triangle Park
05.2004 - 05.2010
Scientist II
Myriad Proteomics
03.2001 - 04.2004
Ph.D. - undefined
St. John’s University
B.S. - undefined
Michigan State University
M.B.A -
Rockford University