Jaishree Sharma

Dynamic Post-Doctoral Research Fellow at Fred Hutchinson Cancer Research Center with expertise in TCR repertoire analysis and CRISPR-Cas9 techniques. Proven track record in project management and developing innovative immunological assays, driving significant advancements in cancer research and mentoring emerging scientists. Committed to excellence in research and collaboration.

• CBLB regulates innate immune responses and bacterial dissemination during nontuberculous mycobacteria infection., Sharma J#, Mudalagiriyappa S#, Abdelaal HFM, Kelly TC, Choi W, Ponnuraj N, Vieson MD, Talaat AM, Nanjappa SG., 2024, Journal of Leukocyte Biology, 115, 6, 1118-1130, 10.1093/jleuko/qiae019
• Lung Immunity to Fungal Infections by Macrophages: Mechanisms and Implications., Sharma J, Arun Kulkarni N, Gowda Nanjappa S., 2024, Macrophages - Molecular Pathways and Immunometabolic Processes, 10.5772/intechopen.1007542
• A smart coating with integrated physical antimicrobial and strain-mapping functionalities for orthopedic implants., Zhang Y, Cui J, Chen K-Y, Kuo SH, Sharma J, Bhatta R, et al., 2023, Science Advances, 9, 18, 10.1126/sciadv.adg7397
• T cell responses to control fungal infection in an immunological memory lens., Sharma J, Mudalagiriyappa S Nanjappa SG., 2022, Front. Immunol., 13, 905867, 10.3389/fimmu.2022.905867
• GM-CSF+ Tc17 cells are required to bolster vaccine immunity against lethal fungal pneumonia without causing overt pathology., Mudalagiriyappa S, Sharma J, Vieson MD, Nanjappa SG., 2022, Cell Reports, 10.1016/j.celrep.2022.111543
• Prevalence, antimicrobial resistance and virulence genes characterization of nontyphoidal Salmonella isolated from retail chicken meat shops in Northern India., Sharma J, Kumar D, Hussain S, Pathak A, Shukla M, V PK, Anisha PN, Rautela R, Upadhyay AK, Singh SP., 2019, Food Control, 10.1016/j.foodcont.2019.01.021

• Outstanding Lightning talk, Pathobiology Graduate Student EXPO, University of Illinois Urbana Champaign, 2023
• Outstanding Presentation Award, Pathobiology Graduate Student EXPO, University of Illinois Urbana-Champaign, 2022
• Ranked as Excellent by students as a Teaching Assistant, University of Illinois Urbana Champaign, 2021
• Graduate College Travel Award, University of Illinois Urbana-Champaign, 2021
• Voss Competition Award, First Prize, Pathobiology Graduate Student EXPO, University of Illinois Urbana-Champaign, 2021
• Voss Competition Award, Honorable Mention, Pathobiology Graduate Student EXPO, University of Illinois Urbana-Champaign, 2020
• Merit Scholarship, G. B. Pant University of Agriculture and Technology, Pantnagar, India, 2016-2018

• Postdoctoral Research Fellow, Dr. Greenberg’s laboratory, Fred Hutchinson Cancer Research Center, Seattle, WA, 05/01/24, Present, Isolated SOX2-specific CD8+ T cells from human peripheral blood and sequence their T cell receptors, Extensively tested candidate T cell receptor construct specificity and sensitivity in vitro, Generated multiple SOX knock out cell lines using CRISPR, Managed and mentored a pair of SHIP (High school) interns
• Graduate Research Assistant, Dr. Nanjappa’s laboratory, University of Illinois, Urbana Champaign, IL, 05/01/19, 05/01/24, Dissertation: The role of E3 ubiquitin ligase CBLB in mediating innate immunity to pulmonary infections, Achieved proficiency in a broad range of immunology and histopathology techniques, applying rigorous standards for sample preparation and analysis., Pioneered the successful extraction and visualization of Toxoplasma cysts from the brains of experimentally infected mice., Developed and optimized customized antibody panels for high-sensitivity detection in immunological assays., Deciphered the role of dual cytokine (GM-CSF+ IL-17A+)-producing CD8+ T cells in vaccine immunity against fungal pneumonia., Investigated the role of myeloid-specific CBLB, an E3 ubiquitin ligase, on immune cells and responses during pulmonary fungal and non-tuberculous mycobacterial infections., Managed the animal colony and maintained the lab's website., Co-authored and drafted manuscripts for publication., Attended professional conferences to present research findings and network with peers in the field., Supervised and trained undergraduate and graduate researchers.
• Senior Research Fellow, Indian Veterinary Research Institute, Indian Council of Agricultural Research (IVRI), Izatnagar, India, 05/01/18, 05/01/19, Contributed to developing sandwich ELISA assay for Japanese Encephalitis virus, Compiled an annual report of research work conducted on 22 viral, bacterial, fungal, rickettsial, and parasitic diseases by 18 collaborating units in India for the project: Outreach Program on Zoonotic diseases
• Project Fellow/ Junior Research Fellow, Defense Research and Development Organization, 05/01/18, 05/01/18, Evaluated the immuno-stimulatory effects of six herbal formulations in rats