Jeffrey D. Levengood
Lab Manager
South Euclid,OH
Summary
An experienced biochemist looking to transition his skills into genetic counseling. Some of my research explored the biochemical effects of deleterious mutations which cause neurodegenerative diseases such as ALS. I wondered how people with the knowledge they possess these mutations must cope. I wish to help such people through a career that will allow me to explain the effects of deleterious mutations and how available therapeutics can treat them.
Overview
21
21
years of professional experience
9
9
years of post-secondary education
Work History
Lab Manager
Case Western Reserve University
06.2017 - Current
- Wrote review articles, lab protocols, and grant supplements
- Conducted analysis of cancer-causing mutations for hnRNP A1, mapping out the mutations to elucidate structural or functional effects
- Trained newcomers to the lab and led lab meetings
- Utilized molecular modeling software to examine SAXS envelopes of disordered protein domains.
Senior Research Associate
Case Western Reserve University
06.2012 - 05.2017
- Perfected purification of hnRNP A1 with disordered domain to keep protein soluble
- Examined effects of deleterious mutations in the C-terminal domain of hnRNP A1 by studying alterations to stress granule assembly and protein fibrilization
- Developed fluorine NMR procedures for examining interactions by hnRNP A1.
Post-Doctoral Fellow
Miami University
01.2010 - 05.2012
- Initiated projects that examined the properties of HIV and EV71 RNA genomic elements
- Analyzed NMR data to study the binding of hnRNP A1 to RNA
- Developed protocols for segmental isotope labeling of RNA and RNA study by EPR.
Post-Doctoral Fellow
University of Cincinnati
01.2007 - 01.2010
- Examined the binding between troponin C and troponin I cardiac N-extension
- Constructed and cloned gene of troponin I: troponin C chimera
- Utilized molecular modeling software to evaluate protein structures.
Graduate Research Assistant
The Ohio State University
06.2002 - 12.2006
- Utilized steady-state kinetics to examine the structure-function relationship of LysRS
- Developed purification procedures for archaeal and bacterial proteins and tRNA
- Reviewed and evaluated journal manuscripts
- Oversaw lab’s compliance with radiation rules and regulations.
Education
Bachelor of Science - Biochemistry
The Ohio State University
Columbus, OH 09.1997 - 06.2001
Doctor of Philosophy - Biochemistry
The Ohio State University
Columbus, OH 09.2001 - 03.2007
Skills
Manuscript Writing
undefinedAdditional Information
- GRANTS , National Institutes of Health training grant HL07832, University of Cincinnati. 2007-2009
Timeline
Lab Manager
Case Western Reserve University
06.2017 - Current
Senior Research Associate
Case Western Reserve University
06.2012 - 05.2017
Post-Doctoral Fellow
Miami University
01.2010 - 05.2012
Post-Doctoral Fellow
University of Cincinnati
01.2007 - 01.2010
Graduate Research Assistant
The Ohio State University
06.2002 - 12.2006
Doctor of Philosophy - Biochemistry
The Ohio State University
09.2001 - 03.2007
Bachelor of Science - Biochemistry
The Ohio State University
09.1997 - 06.2001
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