Jennifer Kyeremateng

Passionate and uniquely experienced Biochemist with 4 plus years’ experience in specialized drug discovery and development background. Seeks to utilize biochemical, analytical and immunological techniques to improve biomedical and translational medicine. Proficient in high throughput assay development and screening, molecular biology, confocal microscopy, multiparametric flow cytometry, ELISA, ELISPOT, Western blot, fluorometry, transport assays and spectroscopy and knowledge of statistical tools such as SoftmaxPro, JMP, PLA, etc. Soft skills: multidisciplinary team player, relationship builder, creative thinker, research project management, research presentations, research proposal writing and manuscript writing for peer reviewed publications. Meticulous Biochemist offering [Number] years of experience managing laboratory experiments, equipment and personnel. Well-versed in developing experiment protocols and reporting on findings. Proven history of applying innovative research methods to drive industry progress.

• CGMP: Introduction to Good Manufacturing Practice, 06/2020
• Analyst software - acquire mode (by SCIEX), 05/2017
• Analyst software - compound and source optimization (by SCIEX), 05/2017

• Scientist III, 02/2022, Present, Pharmaron (Boston) Lab Services, Woburn, MA, Lead Development and Validation of new assays including RUO and GxP studies for gene and immunotherapy products., Author SOPs, Validation Protocols and Reports., Train Scientists on techniques, assays, and providing technical assistance to assigned research staff., Perform QC function to review data and reports to ensure the accuracy of all laboratory-related processes., Perform sample analysis following established SOPs under RUO/GLP/cGMP conditions., Providing high quality documentation of all lab related activities, including, for example, assay batch record, sample inventory, etc., Maintain regular communication with scientists, study director and other project staff as well as external clients.
• Post-Doctoral Research Associate, 06/2021, 01/2022, Center for Vaccines and Immunology, University of Georgia, Athens, GA, Characterized immunologic and physiologic responses to infectious agents in non-human primates for the development of vaccines and immunotherapeutic agents for the prevention and treatment of infectious diseases., Evaluated effector memory T cell response associated with vaccination with KEX protein using intracellular cytokine staining., Quantified KEX protein specific IgG memory B cells, or antigen specific IFNγ by ELISPOT from peripheral blood leukocytes from non-human primates following ex vivo stimulation., Assessed KEX protein antibodies in plasma or BAL samples by ELISA., Processed BAL samples, performing BAL differentials and isolating peripheral blood leukocytes (PBL) or peripheral blood mononuclear cells (PBMC) from EDTA-treated blood from non-human primates.
• Graduate Research Assistant, 08/2016, 05/2021, South Dakota State University, Brookings, SD, Developed fluorescence-based transport activity high throughput assay for profiling a library of 81 novel compounds (cucurbitacin inspired estrone analogs, CIEA) to identify inhibitors for human multidrug resistant proteins from the ATP -binding cassette drug transporter family [Permeability glycoprotein (P-gp) and multidrug resistance protein 1 (MRP1)]., Evaluated and validated CIEA interaction with P-gp and MRP1 using biochemical, cell-based and in silico molecular docking techniques to develop novel therapeutic strategies against multidrug resistance in cancer treatment., Performed flow cytometric and drug sensitivity assays on 4 newly identified modulators of MRP1 from 25 anticancer and FDA-approved drug libraries to address the problem of multidrug resistance in cancer., Prepared and finalized manuscripts based on completed research currently in the process of submission in peer- reviewed journals.
• Lab Safety Officer and Secretary (Iram Lab), 08/2016, 01/2022, South Dakota State University, Brookings, SD, Supervised EHS-compliant biological waste disposal and maintained good laboratory practices (GLP) in the labs., Created EHS biological waste protocol, GLP guidelines and visual aid posters for the lab., Maintained incubator, freezer, liquid nitrogen tanks, scintillators, lab equipment, reagents, and chemicals operational documentation., Organized and coordinated weekly lab meetings to communicate regularly and in timely manner research and operational issues of the laboratory with the PI.
• Manager, Immunology Department, 01/2015, 06/2016, MDS-LANCET Laboratories Ghana Limited, Accra, Ghana, Managed and oversaw the department’s needs and direction per senior management’s goals., Achieved 98% pass in ISO/IEC 15189 (South African Accreditation System (SANAS)) audit checks and department efficiency by improving quality control procedures., Improved patient turnaround times by 30% through optimizing technical and operational tasks.
• Biomedical Scientist, 02/2010, 06/2016, MDS-LANCET Laboratories Ghana Limited, Accra, Ghana, Conducted routine maintenance on Beckman Coulter Access 2, Roche Cobas e411, and other biomedical analyzers to ensure immunological assay accuracy., Ran quality control procedures to maintain and improve department’s internal and external quality control., Collaborated with pioneer bench team to attain ISO/IEC 15189 certification., Improved departmental internal and external quality control by creating comprehensive, periodic quality control instrument maintenance and troubleshooting protocols., Effectively trained new staff to reach competency within allotted six-month window.
• Contract Regulatory Officer, Food Safety Management, 06/2008, 02/2010, Food and Drugs Administration, Accra, Ghana, Led food-borne chemical and biological contamination health risks regulatory and research programs., Inspected, created inspection reports, and developed hospitality and catering facilities training programs., Collaborated with Food Evaluation and Post-Market Surveillance departments to increase auditing and field inspections on food labeling marketing guideline compliance., Trained and inspected over 50 hospitality and catering facilities in three-month period for food- borne chemical and biological contamination.
• Laboratory Technologist Assistant, Chemical Pathology, 11/2005, 08/2006, Komfo Anokye Teaching Hospital (KATH), Kumasi, Ghana, Performed laboratory investigations on hematological samples of diabetic patients., Designed healthy-eating diet plans for diabetic patients and assisted in educating the patients on Diabetes Mellitus management.

• The Effect of Nanosystems on ATP-Binding Cassette Transporters: Understanding the Influence of and P-glycoprotein., International Journal of Molecular Sciences, 21, 7, 2630, 2020
• Triazole-estradiol analogs: A potential cancer therapeutic targeting ovarian and colorectal cancer., Steroids, 177, 108950, 2022
• Evaluation of the experimental and computed properties of choline chloride-water formulated deep eutectic solvents., Journal of Molecular Liquids, 350, 118520, 2022
• Characterization of Cucurbitacin -Inspired Estrone Analogues as Novel Inhibitors for Human P-glycoprotein., In review
• Novel Compound Analogues from Cucurbitacin D Identify as Inhibitors of Multidrug Resistance Protein., In review
• A Cell Based Assay to Identify Efflux Activity of MRP1 on some MRP1 modulators (Manuscript in process).