Jennifer Miconi
Clinton
Summary
Molecular Diagnostics Specialist and ASCP-certified Molecular Biologist with more than 10 years of experience in clinical molecular pathology, oncology testing, next-generation sequencing (NGS), and real-time PCR within CAP/CLIA-regulated laboratories. Expertise in quality assurance, regulatory compliance, assay validation, and laboratory operations. Proven ability to optimize workflows, lead staff training and competency programs, implement new technologies, and enhance operational efficiency in high-complexity clinical testing environments
Overview
1
1
Certification
15
15
years of professional experience
Work History
Molecular Diagnostics Specialist
Yale-New Haven Hospital-Molecular Diagnostics
New Haven
10.2020 - Current
- Supervised daily laboratory operations, prioritizing workflow, staffing schedules, and quality reviews in a high-complexity molecular diagnostics laboratory.
- Coordinated testing activities to ensure timely, accurate reporting in alignment with established turnaround-time metrics.
- Maintained compliance with CAP, CLIA, and Connecticut Department of Public Health regulations.
- Monitored laboratory quality indicators, performance metrics, proficiency testing, and corrective actions.
- Managed inventory, verified reagent quality control, and prepared validation activities per regulatory standards.
- Led validation, implementation, and optimization of new instrumentation, molecular assays, and laboratory processes.
- Authored and revised standard operating procedures (SOPs) alongside technical documentation.
- Participated in hiring, onboarding, competency assessments, training, and performance evaluations of laboratory personnel.
Molecular Technologist B
Yale-New Haven Hospital-Molecular Diagnostics
New Haven
08.2018 - 10.2020
- Performed high-complexity molecular testing including NGS, fragment analysis, PCR, and genomic analysis methodologies.
- Operated and maintained ABI 3500, QuantStudio 7, ABI 7500, Luminex 200, and electrophoresis platforms.
- Processed and accessioned patient specimens utilizing Epic Beaker LIS for efficient workflow.
- Trained students, residents, and fellows in molecular diagnostic laboratory procedures to enhance knowledge.
- Contributed to assay development, validation, quality control, and SOP implementation for accuracy.
- Performed routine maintenance, calibration, and proficiency testing to ensure optimal equipment performance.
Molecular Technologist A
Yale-New Haven Hospital-Tumor Profiling
New Haven
01.2017 - 03.2019
- Isolated DNA and RNA from FFPE tissue using Qiagen technologies.
- Executed automated extraction of DNA and RNA from FFPE tissue, whole blood, and buccal swabs with Promega Maxwell.
- Conducted nucleic acid quantification utilizing Qubit 3.0 fluorometer and NanoDrop 1000 spectrophotometer.
- Performed TaqMan qPCR for SNP analysis on QuantStudio 7 Flex.
- Confirmed SNP mutations through pyrosequencing with Qiagen PyroMark Q24.
- Prepared multiplex PCR libraries for Oncomine Comprehensive Assay and Ion AmpliSeq Cancer Hotspot Panel for NGS.
- Automated template preparation and chip loading of library samples using Ion Torrent Chef System for NGS.
- Contributed to development, validation, and implementation of innovative technologies.
Bench Scientist
Pfizer - Clinical Pharmacogenomics (PGX) Lab
Groton
10.2016 - 12.2016
- Performed DNA/RNA extraction, purification, and quantification from whole blood specimens using automated molecular platforms and associated analytical instruments.
- Conducted pharmacogenomic testing using TaqMan Low Density Arrays (TLDA) and supported biospecimen processing, accessioning, and data management within LIMS.
- Maintained CLIA-compliant laboratory documentation and SOPs, collaborated with clinical teams to resolve specimen issues, and managed inventory, laboratory supplies, and clinical trial budgets.
Clinical Laboratory Technologist
Transgenomic
New Haven
12.2015 - 03.2016
- Performed DNA extraction, purification, quantification, and molecular testing setup using automated and manual methodologies, including PCR and MLPA workflows
Research Assistant
University of Connecticut
Storrs
06.2015 - 12.2015
- Investigated cellular proteins' role in cytoskeleton reorganization by enterohemorrhagic Escherichia coli, elucidating contributions to pathogenesis.
- Conducted bacterial transformation via electroporation, achieving successful colonization.
- Isolated DNA from bacteria for subsequent analysis through gel electrophoresis.
- Executed bacterial infection protocols on mammalian cell lines to assess pathogenicity.
- Performed immunohistochemistry and fluorescence microscopy using Nikon Eclipse Ti with NIS Elements system.
Veterinary Technician
Bloomfield Animal Hospital
Bloomfield
05.2011 - 12.2015
Education
Master of Science - Health Care Genetics
University of Connecticut
Storrs, CT05-2016
Bachelor of Science - Pathobiology
University of Connecticut
Storrs, CT05-2013
Skills
- Molecular diagnostics
- Laboratory leadership
- CAP/CLIA compliance
- Quality assurance and control
- Next generation sequencing
- Real-time PCR
- Assay validation and verification
- Proficiency testing
- Regulatory inspections
- SOP development and implementation
- Staff training and assessment
- Workflow optimization
- Inventory management
- Epic Beaker LIMS
- Molecular oncology
Certification
- American Society for Clinical Pathology (ASCP)
Molecular Biology, MB(ASCP)CM
Timeline
Molecular Diagnostics Specialist
Yale-New Haven Hospital-Molecular Diagnostics
10.2020 - Current
Molecular Technologist B
Yale-New Haven Hospital-Molecular Diagnostics
08.2018 - 10.2020
Molecular Technologist A
Yale-New Haven Hospital-Tumor Profiling
01.2017 - 03.2019
Bench Scientist
Pfizer - Clinical Pharmacogenomics (PGX) Lab
10.2016 - 12.2016
Clinical Laboratory Technologist
Transgenomic
12.2015 - 03.2016
Research Assistant
University of Connecticut
06.2015 - 12.2015
Veterinary Technician
Bloomfield Animal Hospital
05.2011 - 12.2015
Master of Science - Health Care Genetics
University of Connecticut
Bachelor of Science - Pathobiology
University of Connecticut