Jessica O'Brien
Cambridge,MA
Summary
Ambitious and collaborative medicinal chemist with a track record of impactful contributions in molecular design. Passionate about leveraging expertise in data analysis and understanding of structure activity relationships to bring medicines to the world faster.
Overview
2
2
years of professional experience
Work History
Principal Scientist
Pfizer
Cambridge, MA
10.2023 - Current
- Identified and executed an alternate series designed with a differentiated risk profile to meet program objectives. Reached candidate selection.
- Utilize strategic thinking and resource management in design role; routinely manage design risk with synthetic feasibility to ensure research goals are met.
- Highly skilled in Spotfire/D360 analyses to produce designs testing critical hypotheses to reach go/no go decision and identify critical path.
- Proficient in Schrödinger's Maestro software (MD simulation, docking, torsional analysis, FEP).
- Actively seek out and enjoy collaboration across partner lines; currently mentoring a computational chemist on medicinal chemist discipline.
Senior Scientist
Pfizer
Cambridge, MA
09.2021 - 09.2023
Education
Ph.D. - Organic Chemistry
University of Delaware
Newark, DE08-2021
Bachelor of Arts - Chemistry
Williams College
Williamstown, MA06-2016
Skills
- Drug Design and Discovery
- Medicinal Chemistry
- Structure-based Drug Design
- Ligand-based Drug Design
- Computer-aided Drug Design
- Protein-ligand Docking
- Data Analysis (Spotfire/D360)
- Strategic Planning/ Project Management
- Schrodinger's Maestro
- Library/Parallel Medicinal Chemistry Design
- Strain and Conformational Analysis
- Chemical Biology
Publications
- O’Brien, J. G. K.; Jemas, A.; Asare-Okai, P.; am Ende, C.; Fox, J. M. Probing the Mechanism of Photoaffinity Labeling by Dialkyldiazirines through Bioorthogonal Capture of Diazoalkanes. Submitted to Org. Lett. August 2020.
- O’Brien, J. G. K.; Chintala, S. R.; Fox, J. M., Stereoselective Synthesis of Bicyclo[6.1.0]nonene Precursors of the Bioorthogonal Reagents s-TCO and BCN. J. Org. Chem. 2018, 83, 7500-7503.
References
References available upon request.
Timeline
Principal Scientist
Pfizer
10.2023 - Current
Senior Scientist
Pfizer
09.2021 - 09.2023
Ph.D. - Organic Chemistry
University of Delaware
Bachelor of Arts - Chemistry
Williams College
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