Jian Wu
Edmond,OK
Summary
Cancer researcher with more than ten years of experience in multiple myeloma, cancer immunology, ferroptosis, radiation biology, and translational oncology. Extensive expertise in molecular biology, CRISPR/Cas9 gene editing, CAR-T cell engineering, mouse models, flow cytometry, and genomic data analysis. Author of multiple peer-reviewed publications in leading journals including Advanced Science, Blood, Leukemia, Cancer Letters, Biomarker Research, and Cancers. Currently serving as Academic Editor for BMC Cancer and PLOS ONE. Experienced in bridging mechanistic laboratory studies with translational and clinical research in hematologic malignancies.
Overview
12
12
years of professional experience
Work History
Lead researcher
University of Oklahoma Health Sciences, Stephenson Cancer Center
04.2026 - Current
Research associate, Senior in the Division of Hematologic Malignancies and Cellular Therapy
Duke University Medical Center
02.2026 - 04.2026
Postdoctoral in the Division of Hematologic Malignancies and Cellular Therapy
Duke University Medical Center
11.2020 - 02.2026
- Mechanism study on the STAT3 regulates the IL36G expression through binding on the specific area of the promoter.
- Study the SLAMF7 expression and mechanism in the process of multiple myeloma and evaluate the relationship between high SLAMF7 expression level with incidence of myeloma by ethnicity.
- Performed a new CAR T construct which targeted APRIL and IL36G and perform a serious function assay.
- Knock out the SK2 expression with CRISPR/Cas-9
- Handle the clinical patient’s blood samples to isolate the T cells.
- Perform the radiation on the C57BL/6 mice, and do the multiple injection, such as i.v and sc. And collect the blood samples at indicated timepoint. Evaluate the toxicity of some chemicals to the mice.
Postdoctoral in the Department of Laboratory Medicine and Pathobiology
University of Toronto
07.2018 - 10.2020
- Performed CHIP assay to suggest SMAD1 regulates the promoter area of NFKB1.
- Performed the immunofluorescence with Confocal Microscopy to show the SMAD1 expression after reduction with inhibitor.
- Publish one article "SMAD1 as a biomarker and potential therapeutic target in drug-resistant multiple myeloma" was published on Biomarker Research as the first author.
Research fellowship in department of gastroenterology
Xijing Hospital-Air Force Medical University (The Fourth Military University)
01.2014 - 06.2018
- Participate in clinical trials.
Education
Doctor of Medicine - Clinical Medicine
Air Force Medical University
Xi’an, Shaanxi, China06-2018
Master of Medicine - Clinical Medicine
Jiang Su University
Jiangsu, China06-2014
Bachelor of Clinical Medicine - Clinical Medicine
Taishan Medicine University
Shandong, China06-2011
Skills
- PROFESSIONAL SKILLS
- In vivo, independently completed experimental operations, including various introduction, blood collection, centrifugation, sample collection technology, animal anatomy and specimen processing Paraffin section, H&E staining
- In vitro, could handle basic experiments, including cell culture, cytotoxicity and apoptosis assay, shRNA or plasmid transfection, Soft-agar colony formation, migration assay, western blot, RT-PCR, MTT, immunofluorescence, CHIP assay, Luciferase assay, co-IP, Seahorse assay, JC-1 assay
- Familiar with Python basics, dataset analysis, and graph plotting
- Graphpad, GSEA, SPSS
Skills
LANGUAGE SKILLS
Native in Chinese, Fluent in oral and written English.
Positions, Honors
2023. Nominated for the 2023 Outstanding Postdoc at Duke University Award., 2024. Nominated for the 2024 Outstanding Postdoc at Duke University Award., 2022-Present Member, Reviewer Board of International Journal of Clinical Investigation and Case Reports., 2024-Present Academic editor, Editor Board Member for BMC Cancer, 2024-Present Academic editor, Editor Board Member for PLOS ONE
Timeline
Lead researcher
University of Oklahoma Health Sciences, Stephenson Cancer Center
04.2026 - Current
Research associate, Senior in the Division of Hematologic Malignancies and Cellular Therapy
Duke University Medical Center
02.2026 - 04.2026
Postdoctoral in the Division of Hematologic Malignancies and Cellular Therapy
Duke University Medical Center
11.2020 - 02.2026
Postdoctoral in the Department of Laboratory Medicine and Pathobiology
University of Toronto
07.2018 - 10.2020
Research fellowship in department of gastroenterology
Xijing Hospital-Air Force Medical University (The Fourth Military University)
01.2014 - 06.2018
Master of Medicine - Clinical Medicine
Jiang Su University
Bachelor of Clinical Medicine - Clinical Medicine
Taishan Medicine University
Doctor of Medicine - Clinical Medicine
Air Force Medical University