Jicheng Li

In vitro pharmacodynamic assays:

• Performed MIC testing, Hollow Fiber Infection Model (HFIM), and static concentration–time kill (SCTK) on CRAB and MDR P. aeruginosa;
• Conducted Limulus Amebocyte Lysate endotoxin assays to quantify antibiotic-induced bacterial lysis and inflammatory potential.

HFIM data processing:

• Assisted with HFIM data organization and analysis over 7-day humanized antibiotic exposures

PK/PD modeling support:

• Prepared datasets, formatted S-ADAPT input files, and supported exposure–response assessment for PBPK-PD model development;
• Helped interpret killing-curve and HFIM results for the CNS PBPK-PD study

• Assisted senior analysts in the quality control testing of antibacterial drugs in accordance with the Chinese Pharmacopoeia and enterprise specifications.
• Performed HPLC assays (active ingredient quantification, related substances, system suitability) and conducted moisture determination (Karl Fischer) and ash determination (total ash/acid-insoluble ash).
• Responsible for sample preparation, dilution, weighing, filtration, and data recording to ensure analytical accuracy.
• Prepared raw data records and test reports in compliance with GMP/GLP data integrity requirements.
• Supported routine laboratory maintenance including instrument checks, reagent management, and documentation control.

• Engaged in the synthesis and characterization of metal-organic frameworks (MOF) and other compounds;
• Designed and conducted bacteriostatic experiments to examine its antibacterial properties;
• Studied the electrical conductivity using an electrochemical workstation, X-ray diffractometer, and transmission electron microscope.