Jinjing Chen
Palm Beach Gardens,FL
Summary
Driven and passionate about advancing therapeutic solutions for metabolic liver diseases and drug discovery. Dedicated to expanding scientific knowledge to uncover cures that improve patient outcomes. Bringing over a decade of research experience and expertise, ready to contribute meaningfully to innovative projects in biomedical science.
Overview
9
9
years of professional experience
Work History
Staff Scientist
The Herbert Wertheim UF Scripps Institute
07.2024 - Current
- Investigated the role of NRF2 in iron-overloaded liver diseases and liver cancer using advanced cell culture systems and mouse models, providing new insights into disease mechanisms.
- Partnered with medicinal chemists to perform high-throughput screening for small-molecule NRF2 inhibitors, contributing to the identification and optimization of targeted therapeutic candidates.
- Managed animal research protocols, ensuring strict adherence to institutional and ethical guidelines while optimizing experimental design for robust and reproducible results.
- Conducted rigorous data analysis and authored publication-quality manuscripts, resulting in dissemination of findings in leading peer-reviewed journals.
- Supervised research projects and provided methodological training to graduate students and research technicians, promoting skill development and fostering independent scientific inquiry.
Researcher Scientist III
University of Arizona
01.2022 - 05.2024
- Partnered with medicinal chemists to conduct high-throughput screening, identifying and optimizing small-molecule NRF2 inhibitors for targeted therapeutic development.
- Investigated the role of NRF2 in iron-overloaded liver diseases and liver cancer using advanced cell culture systems and mouse models, providing new insights into disease mechanisms.
- Authored and submitted research proposals for state funding, gaining experience in crafting detailed research plans and aligning them with funding priorities, despite funding not being awarded.
- Managed animal research protocols, ensuring full compliance with institutional and ethical guidelines while enhancing experimental design for optimal outcomes
- Utilized CRISPR technology to generate knockout cell lines, enabling precise functional studies of target genes.
- Processed lung tissue from mouse models for single-cell RNA sequencing, providing high-resolution insights into cellular heterogeneity.
- Extracted RNA from mouse tissues and prepared high-quality libraries, supporting large-scale RNA sequencing and transcriptomic studies.
- Conducted tissue sample processing for detailed immune profiling, contributing to advancements in understanding immune responses across various contexts.
- Supervised and mentored graduate students and research technicians, providing methodological training and fostering the development of scientific skills.
Postdoctoral Research Fellow
University Of Illinois At Urbana-Champaign
02.2016 - 12.2021
- Designed and conducted pioneering experiments investigating long non-coding RNAs (lncRNAs) regulated by the Farnesoid X Receptor (FXR), marking the first such studies in the field.
- Identified FXR-regulated lncRNAs using RNA-seq and Global Run-On sequencing, characterized a key lncRNA through biochemical assays, cellular models, murine studies, and analysis of human patient samples, and elucidated its role in metabolic liver diseases.
- Secured competitive research funding through the development and submission of successful grant proposals.
- Managed awarded grants, ensuring compliance with agency requirements and timely submission of annual progress reports.
- Authored high-quality manuscripts published in leading peer-reviewed journals.
- Supervised undergraduate students, providing methodological guidance and fostering the development of technical and analytical skills.
- Engaged in multidisciplinary collaborations to expand the scope and impact of research projects.
- Oversaw laboratory mouse colonies, ensuring proper care and compliance with experimental protocols.
Education
Ph.D. - Biochemical Pharmacology
Peking Union Medical College, Tsinghua University
Beijing, China01.2015
Bachelor of Science - Pharmaceutical Sciences
Zhejiang University
Hangzhou, China07.2009
Skills
- Project leadership and mentoring
- Scientific communication and collaboration
- Hypothesis generation and experiment design
- Data analyses and management
- Drug discovery
- High-throughput screening
- In vivo experiments techniques
- Lentivirus and Adenovirus production and purification (in vivo grade)
- Human patient liver sample processing
- Isolation and culture of primary cells
- Cell biology and molecular biology (molecular cloning, CRISPR knock out, and et al)
- RNA-seq
Timeline
Staff Scientist
The Herbert Wertheim UF Scripps Institute
07.2024 - Current
Researcher Scientist III
University of Arizona
01.2022 - 05.2024
Postdoctoral Research Fellow
University Of Illinois At Urbana-Champaign
02.2016 - 12.2021
Ph.D. - Biochemical Pharmacology
Peking Union Medical College, Tsinghua University
Bachelor of Science - Pharmaceutical Sciences
Zhejiang University
Publications
Google scholar link: https://scholar.google.com/citations?user=zCAfnhwAAAAJ&hl=zh-CN
Intellectual Property
1. China Patent, CN104873499 A [P], The discovery and the anti-osteoporosis role of a novel up-regulator of Runx2 transcriptional activity. Issued on Sep 2, 2015. (Inventors: Wang Zhen, Si Shuyi, Zhao Xiaoli, Chen Jinjing, Chen Lin-Feng)
2. China Patent, CN102174472 B [P], A high-throughput screening model against myocardial hypertrophy and its application. Issued on Apr 10, 2013. (Inventors: Wang Zhen, Wang Yiguang, Chen Jinjing, et al.)
Awards
- 2019: Best oral presentation award (1st place), Annual Retreat of Department of Molecular and Integrative Physiology, UIUC
- 2019: ADA Postdoctoral Fellowship (1-19-PDF-117)
- 2019: AHA Postdoctoral Fellowship (Funding was relinquished due to the concurrent award from ADA)
- 2018: Best poster presentation award, Annual Retreat of Department of Molecular and Integrative Physiology, UIUC
- 2017: Certificate of Outstanding Contribution in Reviewing awarded by International Immunopharmacology
- 2012: Thesis Excellence Award in the 2012 Youth Forum Sponsored by Beijing Pharmacological Society
- 2012: Graduate Students’ Innovation Fund sponsored by Peking Union Medical College (3/32)
- 2010-2011: Excellent Graduate Student Award by Peking Union Medical College
- 2005-2008: Study Scholarship awarded by Zhejiang University each year
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